Query # 4: Does tranexamic acid administration reduce mortality in trauma?

<p>Results of the CRASH 2 trial [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0164090#pone.0164090.ref038" target="_blank">38</a>]. The number of patients is referred to those included in the multivariable model. CI = confidence interval, RR = relative risk, NNTB = number needed to treat for benefit.</p

Query # 3: Does hypofibrinogenemia treatment reduce mortality in trauma?

<p>Reporting of studies included in the revision. The number of patients is referred to those included in the multivariable model. N = number, pts = patients, ctr = centre, OR = odds ratio, CI = confidence interval.</p

Query # 1: Does coagulopathy affect mortality in trauma?

<p>Reporting of studies included in the revision. The number of patients is referred to those included in the multivariable model. N = number, pts = patients, ctr = centre, OR = odds ratio, CI = confidence interval, APTT = activated partial thromboplastin time, PT = prothrombin time, INR = international normalized ratio.</p

Query # 2: Does a fixed blood-plasma transfusion ratio reduce mortality in trauma?

<p>Results of the Pragmatic, Randomized Optimal Platelet and Plasma Ratios (PROPPR) trial [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0164090#pone.0164090.ref037" target="_blank">37</a>]: 24-hour and 30-day mortality are reported. RR = relative risk, CI = confidence interval, NNTB = number needed to treat for benefit, NNTH = number needed to treat to be harmed, FFP = fresh frozen plasma, PRBC = packed red blood cells.</p