Comparing PANSS scores and corresponding CGI scores between stable and acute schizophrenic patients

Universidade Federal de São Paulo, Dept Psychiat, Interdisciplinary Lab Clin Neurosci LiNC, BR-05039032 São Paulo, BrazilHosp Clin Luzia de Pinho Melo SPDM, Dept Mental Hlth, BR-08773130 São Paulo, BrazilSao Jose do Rio Preto Sch Med FAMERP, Dept Psychiat & Med Psychol, BR-15090000 São Paulo, BrazilISCMSP, Dept Psychiat, BR-04017030 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psychiat, Interdisciplinary Lab Clin Neurosci LiNC, BR-05039032 São Paulo, BrazilWeb of Scienc

Hemoencephalography self-regulation training and its impact on cognition: A study with schizophrenia and healthy participants

Background: Cognitive impairments in schizophrenia are strongly correlated to functional outcome and recovery rates, with no pharmacological agent approved for its treatment. Neurofeedback has emerged as a non-pharmacological approach to enhance neuroplasticity, which consists in inducing voluntary control of brain responses through operant conditioning. Method: The effects of hemoencephalography neurofeedback (HEG-NFBK) in 4 brain sites (F7, Fp1, Fp2 and F8) was studied in 8 patients with schizophrenia (SCH, mean age 36.5 +/- 9.98) and 12 health controls (mean age 32.17 +/- 5.6). We analyzed groups' performance (10 sessions) and cognitive differences in 3 time points (baseline, after training and follow-up) with generalized estimated equations. For SCH we also evaluate the impact on psychopathology. Results: We found a group * time interaction for HEG-NFBK performance in the left hemisphere sites (F7 an Fp1) and a near-to-significant in the right frontotemporal region (F8), with no group differences and a significant time effect. Most of cognitive domains improved after intervention, including information processing speed, attention processing, working memory, executive functioning, verbal and visual learning. No group * time interaction was found. Results suggest that both groups benefit from HEG-NFBK training regardless of cognitive differences at baseline. No significant time effects were found for Calgary and PANSS total scale and subscales (positive, negative neither general). Conclusion: To our knowledge, this is the first controlled trial showing effects of NFBK on cognitive performance improvement in schizophrenia. Further research investigating the effects of HEG-NFBK training in schizophrenia should be performed. (C) 2017 Elsevier B.V. All rights reserved.Univ Fed Sao Paulo, Clin Neurosci Lab, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Psychiat, Ctr Neuromodulat Studies, Sao Paulo, BrazilItallis Consciousness Technol, Atlanta, GA USAUniv Fed Rio Grande do Sul, Clin Hosp Porto Alegre, Epidemiol & Biostat Unity, Porto Alegre, RS, BrazilSao Paulo State Secretariat Hlth, Reference Ctr Alcohol Tobacco & Other Drugs CRATOD, Sao Paulo, BrazilUniv Fed Sao Paulo, Clin Neurosci Lab, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Psychiat, Ctr Neuromodulat Studies, Sao Paulo, BrazilWeb of Scienc