The Digital Twin Realization of an Ejector for Multiphase Flows

Despite the extensive use of ejectors in the process industry, it is complex to predict suction and motive fluids mixture characteristics, especially with multiphase flows, even if, in most cases, mixture pressure control is necessary to satisfy process requirements or to avoid performance problems. The realization of an ejector model can allow the operators to overcome these difficulties to have real-time control of the system performance. In this context, this work proposes a framework for developing a Digital Twin of an ejector installed in an experimental plant able to predict the future state of an item and the impact of negative scenarios and faults diagnosis. ANNs have been identified as the most used tool for simulating the multiphase flow ejector. Nevertheless, the complexity in defining their structure and the computational effort to train and use them are not suitable for realizing standalone applications onboard the ejector. The proposed paper shows how Swarm Intelligence algorithms require a low computational complexity and overperform prediction error and computational effort. Specifically, the Grey Wolf optimizer proves to be the best one among those analyzed

Pectin-Based Formulations for Controlled Release of an Ellagic Acid Salt with High Solubility Profile in Physiological Media

Among bioactive phytochemicals, ellagic acid (EA) is one of the most controversial because its high antioxidant and cancer-preventing effects are strongly inhibited by low gastrointestinal absorption and rapid excretion. Strategies toward an increase of solubility in water and bioavailability, while preserving its structural integrity and warranting its controlled release at the physiological targets, are therefore largely pursued. In this work, EA lysine salt at 1:4 molar ratio (EALYS), exhibiting a more than 400 times increase of water solubility with respect to literature reports, was incorporated at 10% in low methoxylated (LM) and high methoxylated (HM) pectin films. The release of EA in PBS at pH 7.4 from both film preparations was comparable and reached 15% of the loaded compound over 2 h. Under simulated gastric conditions, release of EA from HM and LM pectin films was minimal at gastric pH, whereas higher concentrations—up to 300 µM, corresponding to ca. 50% of the overall content—were obtained in the case of the HM pectin film after 2 h incubation at the slightly alkaline pH of small intestine environment, with the enzyme and bile salt components enhancing the release. EALYS pectin films showed a good prebiotic activity as evaluated by determination of short chain fatty acids (SCFAs) levels following microbial fermentation, with a low but significant increase of the effects produced by the pectins themselves. Overall, these results highlight pectin films loaded with EALYS salt as a promising formulation to improve administration and controlled release of the compound.European Union’s Horizon 2020 research and innovation program through the Stance4Health project (Grant No. 816303

Comparison of methodologies and geostatistical approaches for diagenesis quantification

http://www.searchanddiscovery.com/author.shtml#dInternational audienc

Transanal Endoscopic Microsurgery after the attempt of endoscopic removal of rectal polyps

none6The incidence of rectal polyps has steadily increased in recent decades and will continue to rise. [1] The introduction of endoscopic screening programs has probably contributed to the improved detection of rectal polyps and early malignant lesions [2, 3]. With the aim to reduce morbidity and mortality of rectal surgery, in 1983, Gerhard Buess introduced Transanal Endoscopic Microsurgery (TEM) [4]. He conceived a novel endoscopic technology to facilitate the excision of rectal polyps through the anus [5]. This revolutionary technique enabled superfcial or full-thickness excision of large adenomatous lesions. It soon became apparent that indications to TEM could be successfully extended to early malignant polyps [6, 7]. However, in the late nineties, endoscopy was advocated as a diagnostic technique and a therapeutic method. First, large piecemeal snare ablations were reported. Then, the use of endoscopic electrosurgical knives made it possible to achieve en bloc resection, known as Endoscopic Submucosal Dissection (ESD) [8–11]. The sharp increase in endoscopic resection of rectal polyps made the indications for TEM questioned [12]. This unresolved debate confuses the choice of the optimal treatment for complex rectal polyps. Concerns mainly arise where there is uncertainty around early malignancy or where complete resection of an adenomatous polyp is not obtained following endoscopic attempts [13–15]. Accurate prognostic information is not always available after endoscopic removal, mainly when the specimen is fragmented. [16] Additionally, fbrotic tissue growth at the polypectomy site could invalidate the already sub-optimal accuracy of pre-operative imaging techniques. Therefore, endoscopic ultrasound and/or Magnetic Resonance Imaging staging are often misleading [17]. The indication to resect the site of a previous endoscopic resection with a full-thickness technique has been recommended in cases of unexpected malignancy. However, the overall beneft remains unclear [13, 18]. This study aims to evaluate the outcomes of TEM following endoscopic resection of rectal polyps performed at two diferent centres, assess the value of further local excision, and identify features that may contribute to the decisionmaking process.openMonica Ortenzi, Alberto Arezzo, Roberto Ghiselli, Marco Ettore Allaix, Mario Guerrieri, Mario MorinoOrtenzi, Monica; Arezzo, Alberto; Ghiselli, Roberto; Ettore Allaix, Marco; Guerrieri, Mario; Morino, Mari

Preliminary Data Related to the Effect of Climacostol Produced by the Freshwater Ciliate Climacostomum virens on Human Adenovirus

The new epidemiological scenario has so far focused on the environmental circulation of human viral pathogens. Owing to the side effects of chemical disinfectants, there is an increasing need for knowledge on the use of virucidal compounds, especially those of a natural origin. Climacostol is a molecule produced by a freshwater ciliate and it exhibits activity against bacterial and fungal pathogens. We thus also speculated that there might be an effect on viral viability, which has never been tested. To evaluate such activity, we chose human adenovirus (HAdV), which is representative of waterborne viruses. We conducted experiments using HAdV serotype 5, whose titer was determined by infecting HeLa cell cultures. HAdV5 was shown to be sensitive to climacostol at a concentration of 0.0002 mg/mL, with an approximate 3 Log(10)reduction when the initial titer of HAdV5 was approximately 10(4)and 10(3)TCID(50)/mL. These preliminary results could be an important starting point for further research aimed at improving the characterization of climacostol activity under different experimental conditions and against various viruses, including enveloped ones (i.e., the coronavirus). The production of climacostol by a protist living in fresh water also suggests a possible application in the activated sludge of wastewater treatment plants

Biosourced Aromatic Derivatives in the Upcycling of Recycled PET: Mellophanic Dianhydride as a Chain Extender

The synthesis of mellophanic dianhydride (MEDA) from biosourced 1,2,3,4-benzene tetracarboxylic derivatives and its use as a chain extender for mechanically recycled PET (R-PET) as an alternative to traditional oil-based pyromellitic dianhydride (PMDA) is reported. The rheological tests performed on the R-PET extruded with MEDA have shown similar results to those obtained with PMDA, and dynamic mechanical thermal analysis (DMTA) showed that, in the 90–110 °C range (i.e., the temperature range commonly used for blow molding of bottles), Young’s modulus of R-PET containing MEDA is about 20% higher in comparison to that of pristine R-PET. The advantage of MEDA is that it can be prepared using building blocks obtained from agricultural waste via a sustainable protocol, whereas PMDA is a product of oil-based chemistr

On variational formulations and conservation laws for incompressible 2D Euler fluids

With the aim of presenting a unified viewpoint for the variational and Hamiltonian formalism of two-dimensional incompressible stratified Euler equations, we revisit some of the formulations currently discussed in the literature and examine their mutual relations. We concentrate on the example of two-layered systems and its one-dimensional reduction, and use it to illustrate general consequences of density stratification on conservation laws which have been partially overlooked until now. In particular, we focus on the conservation of horizontal momentum for stratified ideal fluid motion under gravity between rigid lids