Synthesis of methylenedioxy and dimethoxy compounds.

It is a very well-known fact that numerous alkaloids contain as a substituent methylenedioxy and/or methoxy groups. Many of these substances possess a characteristic physiological activity and therefore are extensively used in medicine. The significance of these compounds bas provided an impetus for extensive synthetic research by various schools to prepare new related substances of improved biological activity. The fact that many physiologically active substances are oxazines, led us to believe that the combination of a dialkoxybenzene ring with an oxazine nucleus, might give rise to or increase biological activity. In the present work the object was to study the synthesis of a number of 6,7-dialkoxy-1,4-benzoxazin-2-ones and their dihydro-derivatives 2-phenomorpholones

A Hypertext Technical Dictionary With Multimedia Capabilities

(no abstract available

Coupling information extraction and data mining for ontology learning in PARMENIDES

Strategic decision making, especially in the areas of business intelligence and competitive intelligence, requires the acquisition of decision-relevant information pieces like market trends, fusions and company values. This information is extracted by pre-processing and querying multiple sources, combining and condensing the findings. It is characteristic that the extraction process is resource intensive and has to be performed regularly and quite frequently. In the research project PARMENIDES, we are developing methods that establish ontologies over an application domain, annotate documents with the ontology components and identify the entities in them, so that we can decompose business into conventional queries towards entities and XML-annotated texts

Transcriptional map of chromosome region 6q26-q21

We present the transcription map of chromosome region 6q16-->q21 by mapping fifteen known genes within this region. Five genes lay in the subregion containing a tumor suppressor gene, eight genes are located in the subregion harboring a senescence gene, and two genes are distal to the latter region. The precise location of the genes was obtained using a previously described translocation and deletion mouse/human hybrid panel. An even more accurate definition was possible for the genes spanning the senescence gene region, since a previously described YAC contig with its restriction map was available. From this transcription map it is possible to derive a large region of synteny with mouse chromosome 10