Chemical composition and antibacterial activity of essential oils from the medicinal plant Mentha cervina L. grown in Portugal

Mentha cervina is a medicinal plant traditionally used in Portugal in folk medicine, in different gastric disorders and inflammations of the respiratory tract. In order to validate those traditional uses, M. cervina essential oils (EOs) were characterized by GC and GC–MS and their antimicrobial activity was tested against 23 bacterial strains (including multiresistant strains). The EOs were dominated by the monoterpenes pulegone (52–75%), isomenthone (8–24%), limonene (4–6%), and menthone (1–2%). The antibacterial activity of these EOs was compared to that of the main components standards. The most effective antibacterial activity was expressed by the EOs against the Gram-negative bacteria, Escherichia coli and Acinetobacter baumanni, with MIC values of 1 mg/ml. The EOs complex mixtures were more active than the individual aromatic components supporting the hypothesis that the EOs antibacterial activity is a function of the synergistic effect of their different aromatic components. These results show the potential role of M. cervina EOs as antibacterial agents and validate the traditional use of this plant

Benefits of Enterprise Social Networking Systems for High Energy Physics community

The emergence of social media platforms in the consumer space unlocked new ways of interaction between individuals on the Web. People develop now their social networks and relations based on common interests and activities with the choice to opt-in or opt-out on content of their interest. This kind of platforms have also an important place to fill inside large organizations and enterprises where communication and collaborators interaction are keys for development. Enterprise Social Networking Systems (ESN) add value to an organization by encouraging information sharing, capturing knowledge, enabling action and empowering people. CERN is currently rolling out an ESN which aims to unify and provide a single point of access to the multitude of information sources in the organization. It also implements social features that can be added on top of existing communication channels. While the deployment of this kind of platforms is not without risks we firmly believe that they are of the best interest for our community, opening the opportunity to evaluate a global social network for High Energy Physics (HEP)

Sphingolipid-induced cell death in Arabidopsis is negatively regulated by the papain-like cysteine protease RD21

It is now well established that sphingoid Long Chain Bases (LCBs) are crucial mediators of programmed cell death. In plants, the mycotoxin fumonisin B1 (FB1) produced by the necrotrophic fungus Fusarium moniliforme disrupts the sphingolipid biosynthesis pathway by inhibiting the ceramide synthase leading to an increase in the amount of phytosphingosine (PHS) and dihydrosphingosine (DHS), the two major LCBs in Arabidopsis thaliana. To date, the signaling pathway involved in FB1-induced cell death remains largely uncharacterized. It is also well acknowledged that plant proteases such as papain-like cysteine protease are largely involved in plant immunity. Here, we show that the papain-like cysteine protease RD21 (responsive-to-desiccation-21) is activated in response to PHS and FB1 in Arabidopsis cultured cells and leaves, respectively. Using two allelic null mutants of RD21, and two different PCD bioassays, we demonstrate that the protein acts as a negative regulator of FB1-induced cell death in Arabidopsis