Role of Layering Oscillations at Liquid Metal Surfaces in Bulk Recrystallization and Surface Melting

The contrasting melting behavior of different surface orientations in metals can be explained in terms of a repulsive or attractive effective interaction between the solid-liquid and the liquid-vapor interface. We show how a crucial part of this interaction originates from the layering effects near the liquid metal surface. Its sign depends on the relative tuning of layering oscillations to the crystal interplanar spacing, thus explaining the orientational dependence. Molecular dynamics recrystallization simulations of Au surfaces provide direct and quantitative evidence of this phenomenon.Comment: 10 pages (RevTeX) plus 3 figures (PostScript

The cardiovascular risk of young women with polycystic ovary syndrome: an observational, analytical, prospective case-control study

To evaluate the cardiovascular risk of polycystic ovary syndrome (PCOS), we investigated lipid profile, metabolic pattern, and echocardiography in 30 young women with PCOS and 30 healthy age- and body mass index (BMI)-matched women. PCOS women had higher fasting glucose and insulin levels, homeostasis model assessment score of insulin sensitivity, total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) levels, and TC/high density lipoprotein cholesterol (HDL-C) ratio and lower HDL-C levels than controls. Additionally, PCOS women had higher left atrium size (32.0 +/- 4.9 vs. 27.4 +/- 2.1 mm; P < 0.0001) and left ventricular mass index (80.5 +/- 18.1 vs. 56.1 +/- 5.4 g/m(2); P < 0.0001) and lower left ventricular ejection fraction (64.4 +/- 4.1 vs. 67.1 +/- 2.6%; P = 0.003) and early to late mitral flow velocity ratio (1.6 +/- 0.4 vs. 2.1 +/- 0.2; P < 0.0001) than controls. When patients and controls were grouped according to BMI [normal weight (BMI, >18 and <25 kg/m(2)), overweight (BMI, 25.1-30 kg/m(2)), and obese (BMI, >30 kg/m(2))], the differences between PCOS women and controls were maintained in overweight and obese women. In normal weight PCOS women, a significant increase in left ventricular mass index and a decrease in diastolic filling were observed, notwithstanding no change in TC, LDL-C, HDL-C, TC/HDL-C ratio, and TG compared with controls. In conclusion, our data show the detrimental effect of PCOS on the cardiovascular system even in young women asymptomatic for cardiac disease

X-Ray Grating Observations of Recurrent Nova T Pyxidis During The 2011 Outburst

The recurrent nova T Pyx was observed with the X-ray gratings of Chandra and XMM-Newton, 210 and 235 days, respectively, after the discovery of the 2011 April 14 outburst. The X-ray spectra show prominent emission lines of C, N, and O, with broadening corresponding to a full width at half maximum of ~2000-3000 km/s, and line ratios consistent with high-density plasma in collisional ionization equilibrium. On day 210 we also measured soft X-ray continuum emission that appears to be consistent with a white dwarf (WD) atmosphere at a temperature ~420,000 K, partially obscured by anisotropic, optically thick ejecta. The X-ray continuum emission is modulated with the photometric and spectroscopic period observed in quiescence. The continuum at day 235 indicated a WD atmosphere at a consistent effective temperature of 25 days earlier, but with a lower flux. The effective temperature indicates a mass of ~1 solar mass. The conclusion of partial WD obscuration is supported by the complex geometry of non-spherically-symmetric ejecta confirmed in recent optical spectra obtained with the Southern African Large Telescope (SALT) in November and December of 2012. These spectra exhibited prominent [O III] nebular lines with velocity structures typical of bipolar ejecta.Comment: Accepted to ApJ 2013 October 23, 14 pages, 9 figures, 3 table

Relationship between heart rate recovery and inflammatory markers in patients with polycystic ovary syndrome: a cross-sectional study

<p>Abstract</p> <p>Background</p> <p>Polycystic ovary syndrome (PCOS) is an endocrine disease closely related to several risk factors for cardiovascular disease. An abnormal heart rate recovery (HRR), an easily-obtained measure derived from exercise stress test and closely related to an increased risk for cardiovascular mortality, has been recently described in PCOS women. A subclinical increase of the inflammation markers has been also observed in the PCOS. This study was designed to study the relationships between HRR and inflammatory markers in PCOS women.</p> <p>Methods</p> <p>Two-hundred forty-three young PCOS patients without known risk factors for cardiovascular risk were enrolled. All patients underwent hormonal and metabolic profile, white blood cells (WBCs) count and C-reactive protein (CRP). HRR was calculated as the difference between heart rate at peak exercise and heart rate at first minute of the cool-down period. Abnormal HRR was defined as ≤18 beats/min for standard exercise testing.</p> <p>Results</p> <p>Eighty-nine out of 243 patients presented abnormal HRR. Serum CRP (1.8 ± 0.7 vs. 1.1 ± 0.4 mg/dl, <it>p </it>< 0.001) and WBCs (7.3 ± 1.8 vs. 6.6 ± 1.5 10⁹cells/l, <it>p </it>< 0.001) concentrations were significantly higher in PCOS patients with abnormal <it>versus </it>normal HRR. HRR was significantly associated with both CRP (r = -0.33, <it>p </it>< 0.001) and WBCs (r = -0.29, <it>p </it>< 0.001), although in a stepwise multiple regression HRR resulted independently associated with CRP (beta = -0.151, p = 0.001) alone. In a logistic multivariate model, the group within the highest quartile of CRP (odds ratio 1.59, 95% CI 1.07–2.33) was more likely to have abnormal HRR than those within the lowest quartile.</p> <p>Conclusion</p> <p>Abnormal HRR and inflammatory markers are closely associated in PCOS women acting probably in concert to increase the cardiovascular risk profile of these patients.</p

Early impairment of endothelial structure and function in young normal-weight women with polycystic ovary syndrome

The aim of this study was to evaluate the presence of early vascular damage in young normal-weight women with polycystic ovary syndrome (PCOS).Thirty young normal-weight women with PCOS, who had no additional metabolic or cardiovascular diseases, and 30 healthy women (controls) matched for age and body mass index were studied. A complete hormonal assay was performed in each subject. Serum insulin and glucose levels were measured at baseline and after the oral glucose tolerance test. Plasma endothelin-1 levels and serum lipid profile were also assessed. The endothelial function was studied by flow-mediated dilation on the brachial artery, and arterial structure was evaluated by intima-media thickness measurement using Doppler ultrasound of both common carotid arteries.A significant (P &lt; 0.05) difference in flow-mediated dilation (14.3 +/- 1.9% vs. 18.1 +/- 2.0% for PCOS patients and controls, respectively) and in intima-media thickness (0.53 +/- 0.09 mm vs. 0.39 +/- 0.08 mm for PCOS patients and controls, respectively) was found between PCOS and control subjects. Serum endothelin-1 levels were also significantly (P &lt; 0.05) higher in PCOS patients compared with controls (1.1 +/- 0.4 pmol/liter vs. 0.5 +/- 0.2 pmol/liter for PCOS patients and controls, respectively).In conclusion, our data show that young, normal-weight, nondyslipidemic, nonhypertensive women with PCOS have an early impairment of endothelial structure and function

Gut: A key player in the pathogenesis of type 2 diabetes?

The gut regulates glucose and energy homeostasis; thus, the presence of ingested nutrients into the gut activates sensing mechanisms that affect both glucose homeostasis and regulate food intake. Increasing evidence suggest that gut may also play a key role in the pathogenesis of type 2 diabetes which may be related to both the intestinal microbiological profile and patterns of gut hormones secretion. Intestinal microbiota includes trillions of microorganisms but its composition and function may be adversely affected in type 2 diabetes. The intestinal microbiota may be responsible of the secretion of molecules that may impair insulin secretion/action. At the same time, intestinal milieu regulates the secretion of hormones such as GLP-1, GIP, ghrelin, gastrin, somatostatin, CCK, serotonin, peptide YY, GLP-2, all of which importantly influence metabolism in general and in particular glucose metabolism. Thus, the aim of this paper is to review the current evidence on the role of the gut in the pathogenesis of type 2 diabetes, taking into account both hormonal and microbiological aspects

RELAP5 simulation of two-phase flow experiments in vertical helical tubes

In the framework of the studies concerning the thermalfluid dynamic phenomena in helicoidal pipes of the innovative nuclear reactor IRIS steam generators, the Department of Nuclear Engineering of the University of Palermo in collaboration with the Politecnico di Torino Department of Energetics has been engaged in a work aimed to adapt, by implementing new suitable models, RELAP5/mod3.2.2β code to simulate the thermalfluid-dynamics and geometries such as the ones involved in helicoidal pipes. In fact this code is based on one-dimensional thermal-hydraulic relationships and presents limitations to model complicated geometry such as helicoidal pipes. Therefore the code was improved with additional correlations that are valid for two-phase flow and allow to overcome the drawbacks. The validation work of the models that were added is based on the experimental data carried out at the Politecnico di Torino Department of Energetics. In this paper it will be shown that the so modified RELAP5 code allows to represent adequately the experimental data

Endocrine Aspects of Environmental "Obesogen" Pollutants

Growing evidence suggests the causal link between the endocrine-disrupting chemicals (EDCs) and the global obesity epidemics, in the context in the so-called "obesogenic environment". Dietary intake of contaminated foods and water, especially in association with unhealthy eating pattern, and inhalation of airborne pollutants represent the major sources of human exposure to EDCs. This is of particular concern in view of the potential impact of obesity on chronic non-transmissible diseases, such as type 2 diabetes, cardiovascular disease, and hormone-sensitive cancers. The key concept is the identification of adipose tissue not only as a preferential site of storage of EDCs, but also as an endocrine organ and, as such, susceptible to endocrine disruption. The timing of exposure to EDCs is critical to the outcome of that exposure, with early lifetime exposures (e.g., fetal or early postnatal) particularly detrimental because of their permanent effects on obesity later in life. Despite that the mechanisms operating in EDCs effects might vary enormously, this minireview is aimed to provide a general overview on the possible association between the pandemics of obesity and EDCs, briefly describing the endocrine mechanisms linking EDCs exposure and latent onset of obesity

Changes in androgens and insulin sensitivity indexes throughout pregnancy in women with polycystic ovary syndrome (PCOS): relationships with adverse outcomes

<p>Abstract</p> <p>Background</p> <p>Given the high rate of pregnancy and perinatal complications recently observed in patients with polycystic ovary syndrome (PCOS) and the lack of data on the serum variations in androgens and insulin sensitivity indexes in pregnant women with PCOS, the current study was aimed to assess these changes and their potential effect on pregnancy outcomes in a population of women with PCOS.</p> <p>Methods</p> <p>Forty-five pregnant patients with ovulatory PCOS (PCOS group) and other 42 healthy pregnant women (control group) were studied assaying serum androgen levels and insulin sensitivity indexes throughout pregnancy serially, and recording obstetrical outcomes.</p> <p>Results</p> <p>Serum androgen levels and insulin resistance indexes were significantly (<it>p </it>< 0.05) higher in PCOS than in control group at study entry, these differences were sustained throughout pregnancy, and their changes resulted significantly (<it>p </it>< 0.05) different between PCOS and control group. In PCOS patients, women who had a complicated pregnancy showed serum androgen levels and insulin sensitivity indexes significantly (<it>p </it>< 0.05) worse in comparison to subjects without any pregnancy and/or neonatal complications.</p> <p>Conclusions</p> <p>PCOS patients have impaired changes in serum androgen levels and insulin sensitivity indexes during pregnancy. These alterations could be implicated in the pregnancy and neonatal complications frequently observed in women affected by PCOS.</p