1 research outputs found
Antioxidant potential and carbohydrate digestive enzyme inhibitory effects of five Inula species and their major compounds
The present study was designed to examine in-vitro antidiabetic
activities of different extracts of flowers, leaves and roots of Inula
helenium ssp. turcoracemosa, L montbretiana, I. peacockiana, I
thapsoides ssp. thapsoides and I. viscosa extracts. I. viscosa and I.
montbretiana flower, I. thapsoides and I. viscosa leaf and I. helenium
root methanol extracts exhibited remarkable alpha-glucosidase inhibitory
activity. Additionally, alpha-amylase inhibitory activities of the
extracts were moderate at only 3000 mu g/mL. Based on the results of
in-vitro antidiabetic activity tests; antioxidant activities, total
phenol and flavonoid contents of the most promising extracts were
evaluated. To identify compounds responsible for the antidiabetic
activity, major compounds of Inula species were analyzed for their
in-vitro enzyme inhibitory activity. Quercetin, luteolin and rutin
exhibited a significant inhibition on alpha-glucosidase at 10 mM
concentrations. Consequently, Inula species could potentially be used by
diabetic patients for their antidiabetic and antioxidant activities. (C)
2017 SAAB. Published by Elsevier B.V. All rights reserved