Compact Storage for Homomorphic Encryption

Homomorphic encryption (HE) is a promising technology for protecting data in use, with considerable recent years progress towards attaining practical runtime performance. However the high storage overhead associated with HE remains an obstacle preventing its large scale adoption. In this work we propose a new storage solution in the two-server model resolving the high storage overhead associated with HE, while preserving data confidentiality. Our solution attains the following desired properties: 1) *Compact storage* with zero overhead over storing AES ciphertexts, and $10\times$ to $10,000\times$ better than storing CKKS ciphertexts. 2) *Fast runtime performance* for storage and retrieval, only twice the time of directly storing and retrieving HE ciphertexts. 3) *Dynamic control during retrieval* of the HE parameters and the data items to be packed in each HE ciphertext. 4) *Plug-and-play compatibility* with any homomorphic computation. We implemented our solution into a proof-of-concept system running on AWS EC2 instances with AWS S3 storage, empirically demonstrating its appealing performance. As a central tool we introduce the first perfect secret sharing scheme with fast homomorphic reconstruction over the reals; this may be of independent interest

Transcatheter edge-to-edge mitral valve repair in patients with acute decompensated heart failure due to severe mitral regurgitation

Background: Transcatheter edge-to-edge mitral valve repair (TEER) has been established as a therapy for severe symptomatic mitral regurgitation (MR) in stable patients, and it has recently emerged as a reasonable option for acutely ill patients. The aim of this study was to evaluate the safety and efficacy of TEER in hospitalized patients with acute decompensated heart failure (ADHF) and severe MR that was deemed to play a major role in their deterioration. Methods: We included 31 patients who underwent emergent TEER for MR ≥ 3+ from 2012 to 2022 at Sheba Medical Center. Outcomes included procedural safety, procedural success, all-cause mortality, heart failure readmission, and functional improvement. Outcomes were evaluated at 3 months and at 1 year. Data were obtained retrospectively by chart review. Results: Implantation of a TEER device was achieved in 97% of patients, and reduction in MR severity of at least two grades and final MR ≤ 2+ at discharge was achieved in 74%. No intra-procedural mortality or life-threatening complications were noted. Mortality at 30 days was 23%. No excess mortality occurred beyond 6 months, with a total mortality of 41%. At 1 year all survivors had MR ≤ 2+, all were free of heart failure hospitalizations, and 88% were at New York Heart Association class ≤ II. Conclusions: Mitral valve TEER for patients with ADHF and significant MR is safe, feasible, and achieves substantial reduction in MR severity. Despite high early mortality, procedural success is associated with good long-term clinical outcomes for patients surviving longer than 6 months

Israeli identity formation and the Arab-Israeli conflict in election platforms, 1969-2006

This study focuses on the relationship between national identity and intractable conflict. Abdelal's definition of collective identity that refers to the level of agreement regarding the purposes, practices, relational comparisons with other entities, and narratives that define collective identity was adapted to national identity during intractable conflict and was later applied to Israel's national identity. A review of the Israeli 1969-2006 election platforms shows that in the 1980s and 1990s significant changes occurred in Israel's national identity. The most significant changes included: changes regarding the territorial purpose of Israeli identity; changes in practices on who may become an Israeli citizen; changes of perception of the relationship between Israel and the Arabs; and a growing Israeli acceptance of Palestinian identity. Since 2000, following the failure of the Israeli-Palestinian peace process, some components of Israeli national identity have reverted to their original form. The study indicates that the Arab-Israeli conflict triggered changes in Israel's national identity, but the conflict also seemed affected by changes in that identity. The article connects the changes in Israeli national identity to specific mechanisms and conditions of conflict resolution and reconciliation.election platforms, internalization, Israeli-Palestinian, national identity, ripeness

Supplementary Educational Model (Sem) In Social Work Education For Health Care Settings

A supplementary educational model (SEM) was developed and evaluated in order to expand educational opportunities for social work students, to enable a professional interaction for field instructors and to connect the academia teachers to the field. The study highlights the importance of SEM to update the current academic curricula to meet the ongoing changes and challenges in health care settings. One hundred thirty-seven B.A. students and 58 field instructors employed in health care settings participated in the project. Results indicated that 90% of the participants rated the knowledge contributions of the study days and study day satisfaction positively. The results suggest that SEM has potential as a tool to complement traditional field instruction programs

High-throughput analysis of the transcriptional patterns of sexual genes in malaria

Abstract Background Plasmodium falciparum (Pf) is the leading protozoan causing malaria, the most devastating parasitic disease. To ensure transmission, a small subset of Pf parasites differentiate into the sexual forms (gametocytes). Since the abundance of these essential parasitic forms is extremely low within the human host, little is currently known about the molecular regulation of their sexual differentiation, highlighting the need to develop tools to investigate Pf gene expression during this fundamental mechanism. Methods We developed a high-throughput quantitative Reverse-Transcription PCR (RT-qPCR) platform to robustly monitor Pf transcriptional patterns, in particular, systematically profiling the transcriptional pattern of a large panel of gametocyte-related genes (GRG). Initially, we evaluated the technical performance of the systematic RT-qPCR platform to ensure it complies with the accepted quality standards for: (i) RNA extraction, (ii) cDNA synthesis and (iii) evaluation of gene expression through RT-qPCR. We then used this approach to monitor alterations in gene expression of a panel of GRG upon treatment with gametocytogenesis regulators. Results We thoroughly elucidated GRG expression profiles under treatment with the antimalarial drug dihydroartemisinin (DHA) or the metabolite choline over the course of a Pf blood cycle (48 h). We demonstrate that both significantly alter the expression pattern of PfAP2-G, the gametocytogenesis master regulator. However, they also markedly modify the developmental rate of the parasites and thus might bias the mRNA expression. Additionally, we screened the effect of the metabolites lactate and kynurenic acid, abundant in severe malaria, as potential regulators of gametocytogenesis. Conclusions Our data demonstrate that the high-throughput RT-qPCR method enables studying the immediate transcriptional response initiating gametocytogenesis of the parasites from a very low volume of malaria-infected RBC samples. The obtained data expand the current knowledge of the initial alterations in mRNA profiles of GRG upon treatment with reported regulators. In addition, using this method emphasizes that asexual parasite stage composition is a crucial element that must be considered when interpreting changes in GRG expression by RT-qPCR, specifically when screening for novel compounds that could regulate Pf sexual differentiation. Graphical Abstrac