First-Time Home Buyers and Residential Investment Volatility

Like other macroeconomic variables, residential investment has become much less volatile since the mid-1980s (recent experience notwithstanding.) This paper explores the role of structural change in this decline. Since the the early 1980s there have been many changes in the underlying structure of the economy, including those in the mortgage market which have made it easier to acquire a home. We examine how these changes affect residential investment volatility in a life-cycle model consistent with micro evidence on housing choices. We find that a decline in the rate of household formation, increased delay in marriage, and an increase in the cross-sectional variance of earnings drive the decline in volatility. Our findings provide support for the view that the Great Moderation in aggregate fluctuations is not just due to smaller aggregate shocks, but is driven at least in part by structural change

The Boundaries of Justice: The Challenges of Environmental Justice Assessments for Transportation Projects

Over recent decades, federal guidelines for transportation projects have required increasing attention to impacts on communities. Executive Order 12898 requires federal agencies to conduct environmental justice (EJ) assessments to determine if negative effects from projects will fall disproportionately on minority or low-income populations. Yet transportation agencies have not given specific guidance on the method for conducting such assessments. Therefore practitioners and researchers apply a variety of analytical techniques. This paper uses a case study of a planned road widening project in Daytona Beach, Florida, to compare the various methods currently used in EJ assessments. The choice of reference area and of method for determining the decision threshold for a finding of disproportionality are shown to have important implications for the outcome of an assessment. Because the spatial distribution of racial/ethnic and low-income groups will vary widely from place to place, practitioners and transportation agencies should not decide on the precise method, but carefully consider the characteristics and distribution of the data being used and select the method that most fairly represents the data distribution. Conducting genuine EJ assessments is not only required by federal regulations, but can head off conflicts, better reveal the true costs of projects, and allow for more equitable distribution of costs and benefits by better targeting mitigation efforts. Thus rather than shying away from EJ assessments, transportation agencies and practitioners should continue to explore methods and approaches.Master of City and Regional Plannin

Activation of T lymphocytes for the adoptive immunotherapy of cancer

Background: Adoptive immunotherapy of malignancy involves the passive transfer of antitumor-reactive cells into a host in order to mediate tumor regression. Based on animal models, the transfer of immune lymphoid cells can eradicate widely disseminated tumors and establish long-term systemic immunity. Critical for successful adoptive immunotherapy is the ability to isolate large numbers of immune cells. For clinical therapy, it will require the development of in vitro methods to promote the sensitization and propagation of tumor-reactive cells. However, this is formidable task since human cancers are postulated to be poorly immunogenic because of their spontaneous origins.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/41399/1/10434_2006_Article_BF02303568.pd

A History of Universalism: Conceptions of the Internationality of Science from the Enlightenment to the Cold War

That science is fundamentally universal has been proclaimed innumerable times. But the precise geographical meaning of this universality has changed historically. This article examines conceptions of scientific internationalism from the Enlightenment to the Cold War, and their varying relations to cosmopolitanism, nationalism, socialism, and 'the West'. These views are confronted with recent tendencies to cast science as a uniquely European product