1,793 research outputs found
Individual Differences of How Attention is Allocated During Reading
The current study replicates a previous finding of how attention is allocated during reading and was expanded upon by controlling for individual differences between participants. An eye-tracking experiment was performed to determine how attention is allocated during reading, while individual differences between participants were recorded by measuring working memory capacity. In four tasks that increased in depth of processing, participants were instructed to correctly identify whether or not a target was presented in a series of 1-4 words. Results indicate a relationship between reaction time and working memory score in all but one task. This suggests that high-span individuals use parallel processing when detecting symbols or orthographic features, but use serial processing during tasks that require full semantic processing
Monitoring viral infection after allogeneic stem cell transplantation–single center experience
Chronic neural probe for simultaneous recording of single-unit, multi-unit, and local field potential activity from multiple brain sites
Drug resistant focal epilepsy can be treated by resecting the epileptic focus
requiring a precise focus localization using stereoelectroencephalography
(SEEG) probes. As commercial SEEG probes offer only a limited spatial
resolution, probes of higher channel count and design freedom enabling the
incorporation of macro and microelectrodes would help increasing spatial
resolution and thus open new perspectives for investigating mechanisms
underlying focal epilepsy and its treatment. This work describes a new
fabrication process for SEEG probes with materials and dimensions similar to
clinical probes enabling recording single neuron activity at high spatial
resolution. Polyimide is used as a biocompatible flexible substrate into which
platinum electrodes and leads are...
The resulting probe features match those of clinically approved devices.
Tests in saline solution confirmed the probe stability and functionality.
Probes were implanted into the brain of one monkey (Macaca mulatta), trained to
perform different motor tasks. Suitable configurations including up to 128
electrode sites allow the recording of task-related neuronal signals. Probes
with 32 and 64 electrode sites were implanted in the posterior parietal cortex.
Local field potentials and multi-unit activity were recorded as early as one
hour after implantation. Stable single-unit activity was achieved for up to 26
days after implantation of a 64-channel probe. All recorded signals showed
modulation during task execution. With the novel probes it is possible to
record stable biologically relevant data over a time span exceeding the usual
time needed for epileptic focus localization in human patients. This is the
first time that single units are recorded along cylindrical polyimide probes
chronically implanted 22 mm deep into the brain of a monkey, which suggests the
potential usefulness of this probe for human applications
Parietal maps of visual signals for bodily action planning
The posterior parietal cortex (PPC) has long been understood as a high-level integrative station for computing motor commands for the body based on sensory (i.e., mostly tactile and visual) input from the outside world. In the last decade, accumulating evidence has shown that the parietal areas not only extract the pragmatic features of manipulable objects, but also subserve sensorimotor processing of others’ actions. A paradigmatic case is that of the anterior intraparietal area (AIP), which encodes the identity of observed manipulative actions that afford potential motor actions the observer could perform in response to them. On these bases, we propose an AIP manipulative action-based template of the general planning functions of the PPC and review existing evidence supporting the extension of this model to other PPC regions and to a wider set of actions: defensive and locomotor actions. In our model, a hallmark of PPC functioning is the processing of information about the physical and social world to encode potential bodily actions appropriate for the current context. We further extend the model to actions performed with man-made objects (e.g., tools) and artifacts, because they become integral parts of the subject’s body schema and motor repertoire. Finally, we conclude that existing evidence supports a generally conserved neural circuitry that transforms integrated sensory signals into the variety of bodily actions that primates are capable of preparing and performing to interact with their physical and social world
From Observed Action Identity to Social Affordances
Others' observed actions cause continuously changing retinal images, making it challenging to build neural representations of action identity. The monkey anterior intraparietal area (AIP) and its putative human homologue (phAIP) host neurons selective for observed manipulative actions (OMAs). The neuronal activity of both AIP and phAIP allows a stable readout of OMA identity across visual formats, but human neurons exhibit greater invariance and generalize from observed actions to action verbs. These properties stem from the convergence in AIP of superior temporal signals concerning: (i) observed body movements; and (ii) the changes in the body-object relationship. We propose that evolutionarily preserved mechanisms underlie the specification of observed-actions identity and the selection of motor responses afforded by them, thereby promoting social behavior
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