A Lucky Mistake: The Splenic Glands of Marcello Malpighi

PURPOSE OF THE REVIEW: More than 50% of all gynaecological cancers can be classified as rare tumours (defined as an annual incidence of <6 per 100,000) and such tumours represent an important challenge for clinicians. RECENT FINDINGS: Rare cancers account for more than one fifth of all new cancer diagnoses, more than any of the single common cancers alone. Reviewing the RARECAREnet database, some of the tumours occur infrequently, whilst others because of their natural history have a high prevalence, and therefore appear to be more common, although their incidence is also rare. Harmonization of medical practice, guidelines and novel trials are needed to identify rare tumours and facilitate the development of new treatments. Ovarian tumours are the focus of this review, but we comment on other rare gynaecological tumours, as the diagnosis and treatment challenges faced are similar. FUTURE: This requires European collaboration, international partnerships, harmonization of treatment and collaboration to overcome the regulatory barriers to conduct international trials. Whilst randomized trials can be done in many tumour types, there are some for which conducting even single arm studies may be challenging. For these tumours alternative study designs, robust collection of data through national registries and audits could lead to improvements in the treatment of rare tumours. In addition, concentring the care of patients with rare tumours into a limited number of centres will help to build expertise, facilitate trials and improve outcomes

The PAMELA Time-of-Flight system: status report

Abstract The PAMELA (Payload for Antimatter Matter Exploration and Light-nuclei Astrophysics) satellite-borne experiment, scheduled to be launched in 2003, aboard a Soyuz TM2 rocket, is designed to provide a better understanding of the antimatter component of cosmic rays. In the following we report on the features and performances of its scintillator telescope system which will provide the primary experimental trigger and time-of-flight particle identification

Three-axial Fiber Bragg Grating Strain Sensor for Volcano Monitoring

Fiber optic and FBGs sensors have attained a large diffusion in the last years as cost-effective monitoring and diagnostic devices in civil engineering. However, in spite of their potential impact, these instruments have found very limited application in geophysics. In order to study earthquakes and volcanoes, the measurement of crustal deformation is of crucial importance. Stress and strain behaviour is among the best indicators of changes in the activity of volcanoes .. Deep bore-hole dilatometers and strainmeters have been employed for volcano monitoring. These instruments are very sensitive and reliable, but are not cost-effective and their installation requires a large effort. Fiber optic based devices offer low cost, small size, wide frequency band, easier deployment and even the possibility of creating a local network with several sensors linked in an array. We present the realization, installation and first results of a shallow-borehole (8,5 meters depth) three-axial Fiber Bragg Grating (FBG) strain sensor prototype. This sensor has been developed in the framework of the MED-SUV project and installed on Etna volcano, in the facilities of the Serra La Nave astrophysical observatory. The installation siteis about 7 Km South-West of the summit craters, at an elevation of about 1740 m. The main goal of our work is the realization of a three-axial device having a high resolution and accuracy in static and dynamic strain measurements, with special attention to the trade-off among resolution, cost and power consumption. The sensor structure and its read-out system are innovative and offer practical advantages in comparison with traditional strain meters. Here we present data collected during the first five months of operation. In particular, the very clear signals recorded in the occurrence of the Central Italy seismic event of October 30th demonstrate the performances of our device.PublishedWien7TM. Sviluppo e Trasferimento Tecnologic

Insight Into Campi Flegrei Caldera Unrest Through Seismic Tremor Measurements at Pisciarelli Fumarolic Field

Within a general volcanic unrest in the densely urbanized area of Campi Flegrei caldera (Italy) an increase in the activity of Pisciarelli hydrothermal area is occurring. The seismic amplitude of Pisciarelli fumarolic tremor is a proxy for the fluid emission rate of the entire Solfatara‐Pisciarelli hydrothermal system. The long‐term analysis indicates a significant increase, by a factor of ~3 of the fumarolic tremor amplitude since May 2017. This increment matches with the trend of geochemical and seismic parameters observed in Campi Flegrei, therefore highlighting that Pisciarelli is a key site to monitor the volcanic unrest underway in this high‐risk caldera. The analysis of data from three closely spaced seismic stations provided new clues about the source mechanism of the tremor. Analyzing the fumarolic tremor amplitude we could also identify an episode of enlargement of the emission area close to the main fumarole of Pisciarelli. We propose a monitoring system based on the fumarolic tremor analysis, which provides real‐time information on the Pisciarelli hydrothermal activity and therefore on the current unrest in Campi Flegrei caldera.Published5544-55554V. Processi pre-eruttiviJCR Journa

The ToF and Trigger electronics of the PAMELA experiment

The PAMELA satellite-borne experiment, scheduled to be launched in 2004, is designed to provide a better understanding of the antimatter component of the cosmic rays. Its ToF scintillator system will provide the primary experimental trigger and time-of-flight particle identification. The time resolution requested is σ, < 120 ps. To fulfill the detector requirements the digitization electronics should have a time resolution ≤ 50 ps and provide a wide dynamic range for charge measurements. The peculiarity of the developed electronics arises from the need to obtain such a time resolution operating in a satellite environment, which implies low-power consumption, radiation hardness, redundancy and high reliability

Preliminary analysis of site effects in the Ischia island: new insights from md 4.0 earthquake of 21 august 2017 and seismic noise data

On August 21, 2017, at 18:57 UTC, an earthquake of MD 4.0 occurred in Casamicciola, district of Ischia island. The damage caused by the earthquake was massive, with two victims and several buildings collapsed, and circumscribed to the areas of uptown Casamicciola, particularly in the Piazza Maio-La Rita area, and in a small area, called Fango, in Lacco Ameno. Medium and minor damages occurred in Piazza Bagni, in the area around the town hall of Casamicciola and in the Sentinella area. Even assuming the poor quality constructions and/or not in compliance with the anti-seismic regulations, such a level of damage has induced the scientific community to analyse the effects of local site amplifications, that usually are not negligible in volcanic areas. As a matter of fact the seismic station IOCA, located very close to the high damage areas, recorded a peak ground acceleration (PGA) of 2.6 m/s2. This paper is aimed to study the possible site amplification in the areas heavily affected by the August 21 earthquake in order to better understand the causes of these macroseismic effects and high damage levels already observed in the past.PublishedCentro Congressi della Stazione Marittima, Trieste, Italy6V. Pericolosità vulcanica e contributi alla stima del rischi

The MURAVES muon telescope: technology and expected performances

The MURAVES project aims to study the inner structure of the upper part of the Mt. Vesuvius volcano by muon radiography (muography) technique. Very high energy muons, produced by cosmic rays in the at- mosphere, can penetrate large thickness of rocks. By measuring the at- tenuation of the muons flux trough the volcano cone is possible to obtain a 2D image of the density structure. Internal discontinuities, with a spa- tial resolution of about 10 m, can be, in principle, resolved. An absolute average density measurement can be provided too. The project, funded by the Italian Ministry of University, Research and Education (MIUR), is led by INGV and INFN. In this article the mechanical structure of the de- tectors and background suppression techniques are reported

Seismological monitoring of the February 2007 effusive eruption of the Stromboli volcano

On February 27, 2007, the Stromboli volcano, which has usually been characterized by moderate explosive activity, started an effusive eruption with a small lava flow down the NW flank. The permanent broadband network installed on the island allowed the revealing of anomalies in the seismicity before the effusive eruption and for the phenomena to be followed over time, thus obtaining meaningful information about the eruption dynamics. During the effusive phase, a major explosion occurred on March 15, 2007. On that occasion, two strainmeters deployed on the volcano in the previous year recorded a strain increment before the blast. After this explosion, which further destabilized the upper part of the edifice, swarms of Long-Period (LP) and hybrid events were recorded. The characteristics and locations of these events suggest that they were associated with the fracturing processes that affected the summit area of the cone. During the effusive phase, changes in the Very Long Period (VLP) event location were recorded. This type of events accompanied the change in the eruptive style, providing information about the magmatic conduit involved in their seismogenetic processes. The effusive phase stopped on April 2, 2007, and the typical Strombolian activity restarted some months later

Geophysical monitoring of Stromboli volcano: insight into recent volcanic activity

Stromboli is an open conduit strato-volcano of the Aeolian archipelago (Italy), characterized by typical Strom-bolian explosive activity, lasting for several centuries, and by the emission of huge amounts of gas. The normalactivity of Stromboli is characterized by some hundreds of moderate explosions per day. Major explosions, whichlaunch scoria up to hundreds of meters from the craters, lava flows and paroxysmal explosions, which producelarge ballistic blocks, sometimes take place. During the effusive eruption in 2002 - 2003, which caused a tsunamiwith waves of about 10 meters high along the coasts of the Island, the monitoring system was enhanced. In 2006INGV has added two Sacks-Evertson borehole volumetric dilatometers to the surveillance system, in order to mon-itor changes in the local strain field by measuring areal strain. Today we have a large amount of geophysical dataand observations that allow us to better understand how this volcano works. After a period of low explosive activitystarted in mid-2014, Stromboli has shown a more intense explosive activity in the last few months. During the re-cent phase of increased activity, the geophysical monitoring system detected four major explosions occurred on 26July, 23 October, 1 November and 1 December 2017, respectively. The current phase of reawakening of Strombolivolcano has led the Italian civil protection authorities to decree the "attention" alert level (yellow) on the Island.PublishedVienna, Austria1IT. Reti di monitoraggio e sorveglianz