Adult acute megakaryoblastic leukemia: rare association with cytopenias of undetermined significance and p210 and p190 BCR–ABL transcripts

Delia Dima,1,* Liana Oprita,2,* Ana-Maria Rosu,3,* Adrian Trifa,4 Cristina Selicean,1 Vlad Moisoiu,3 Ioana Frinc,1 Mihnea Zdrenghea,1,5 Ciprian Tomuleasa1,3,5 1Department of Hematology, Ion Chiricuta Oncology Institute, 2Department of Dentistry, 3Research Center for Functional Genomics and Translational Medicine, 4Department of Genetics, 5Department of Hematology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania *These authors contributed equally to this work Abstract: Acute megakaryocytic leukemia (M7-AML) is a rare form of acute myeloid leukemia (AML), which is associated with poor prognosis. The case presented in the current report is a statement for the difficult diagnosis and clinical management of M7-AML in the context of a previous hematologic disorder of undetermined significance and associated genetic abnormalities. Probably, following the complete hematologic remission and further with induction chemotherapy plus tyrosine kinase inhibitor therapy, the clinical management of this case will be followed by a allogeneic bone marrow transplantation, the only proven therapy to improve overall survival. Keywords: acute megakaryocytic leukemia, BCR–ABL transcript&nbsp