4 research outputs found
Trudno艣ci diagnostyczne w rozpoznawaniu zespo艂u antysyntetazowego
Zesp贸艂 antysyntetazowy to rzadki podtyp idiopatycznych miopatii zapalnych, charakteryzuj膮cy si臋 wsp贸艂wyst臋powaniem zapalenia mi臋艣ni, zapalenia staw贸w, choroby 艣r贸dmi膮偶szowej p艂uc, objawu Raynauda, gor膮czki oraz r膮k mechanika. Objawy choroby mog膮 ujawnia膰 si臋 r贸偶noczasowo. Markerem immunologicznym choroby jest obecno艣膰 przeciwcia艂 antysyntetazowych w surowicy pacjenta. Trafne rozpoznanie zespo艂u antysyntetazowego pozostaje wyzwaniem diagnostycznym, a diagnoza cz臋sto stawiana jest z op贸藕nieniem. W pracy zosta艂y om贸wione mo偶liwe trudno艣ci w procesie diagnostycznym zespo艂u antysyntetazowego
Difficulties in the diagnosis of antisynthetase syndrome
Antisynthetase syndrome is a rare subtype of idiopathic inflammatory myopathies, characterised by co-ocurrence of myositis, arthritis, interstitial lung disease, Raynaud phenomenon, fever and mechanic鈥檚 hands. Symptoms frequently appear asynchronously. The presence of antisynthetase antibodies in a patient鈥檚 serum is considered an immunological hallmark of the disease. Arriving at a proper diagnosis of antisynthetase syndrome remains a considerable challenge, and the diagnosis is often delayed. The manuscript discusses possible obstacles in the diagnostic process of antisynthetase syndrome
Efficacy and safety of tocilizumab in adult-onset Still's disease: Real-life experience from the international AIDA registry
Long-term efficacy and safety of tocilizumab (TCZ) in adult-onset Still's disease (AOSD) mostly derive from small case series. Herein we report a registry-based study investigating TCZ efficacy and safety in a cohort of patients with AOSD evaluated by clinical and serum inflammatory markers as well as drug retention rate analysis