Bottlenecks in the provision of quality mental health services in Eritrea

Background: The prevalence of mental disorders is increasing significantly in developing countries due to the frequently occurring major risk factors. There is no published information on the profile of mental health disorder and services in Eritrea. Objective of the study: Follow-up descriptive study was conducted on one hundred and one consecutive children with advanced HIV disease who were put on antiretroviral therapy from September 2005 to October 2006. These patients were followed up at the antiretroviral therapy (ART) clinic of the hospital. Methods: A descriptive cross sectional study was conducted using the WHO-AIMS questionnaire that was administered to relevant stakeholders. Results: There was no comprehensive mental health policy and legislation in Eritrea. Only 5% of the health services budget is allocated for mental health services. Mental health services is free of charge and were provided integrated with Primary Health Care services. Inadequate human resources and inadequate training on mental health for the health workers were among the constraints. Conclusion: The status of mental disorders and the mental health services in Eritrea from the policy to management guidelines requires urgent review. Significant Outcomes: a) In resource limited settings, the integrated primary health care approach for mental health services is cost effective and avoids associated stigma. b) WHO/AIMS tool is a simple tool that provides complete picture of the mental health system of a country, c) Lack of policies and legislation in a country severely affects the mental health system of a country Limitations: This was a cross sectional study where data collection and analysis was partially restricted by the level and quality of information available in the registry books of the health facilities. Key words: WHO-AIMS, integrated primary health care, mental health services

Superconducting thin films of MgB2 on (001)-Si by pulsed laser deposition

Superconducting thin films have been prepared on Si-substrates, using pulsed laser deposition from a target composed of a mixture of Mg and MgB2 powders. The films were deposited at room temperature and post-annealed at 600 degrees C. The zero resistance transition temperatures were 12 K, with an onset transition temperature of 27 K. Special care has been taken to avoid oxidation of Mg in the laser plasma and deposited film, by optimizing the background pressure of Ar gas in the deposition chamber. For this the optical emission in the visible range from the plasma has been used as indicator. Preventing Mg from oxidation was found to be essential to obtain superconducting films

Barium & related stars and their white-dwarf companions II. Main-sequence and subgiant stars

Barium (Ba) dwarfs and CH subgiants are the less-evolved analogues of Ba and CH giants. They are F- to G-type main-sequence stars polluted with heavy elements by a binary companion when the latter was on the Asymptotic Giant Branch (AGB). This companion is now a white dwarf that in most cases cannot be directly detected. We present a large systematic study of 60 objects classified as Ba dwarfs or CH subgiants. Combining radial-velocity measurements from HERMES and SALT high-resolution spectra with radial-velocity data from CORAVEL and CORALIE, we determine the orbital parameters of 27 systems. We also derive their masses by comparing their location in the Hertzsprung-Russell diagram with evolutionary models. We confirm that Ba dwarfs and CH subgiants are not at different evolutionary stages and have similar metallicities, despite their different names. Additionally, Ba giants appear significantly more massive than their main-sequence analogues. This is likely due to observational biases against the detection of hotter main-sequence post-mass-transfer objects. Combining our spectroscopic orbits with the Hipparcos astrometric data, we derive the orbital inclinations and the mass of the WD companion for four systems. Since this cannot be done for all systems in our sample yet (but should be with upcoming Gaia data releases), we also analyse the mass-function distribution of our binaries. We can model this distribution with very narrow mass distributions for the two components and random orbital orientation on the sky. Finally, based on BINSTAR evolutionary models, we suggest that the orbital evolution of low-mass Ba systems can be affected by a second phase of interaction along the Red Giant Branch of the Ba star, impacting on the eccentricities and periods of the giants.Comment: Accepted for publication in A&A on the 5th of April, 201

Resveratrol Preserves Cerebrovascular Density and Cognitive Function in Aging Mice

Resveratrol, a natural polyphenol abundant in grapes and red wine, has been reported to exert numerous beneficial health effects. Among others, acute neuroprotective effects of resveratrol have been described in several models of neurodegeneration, both in vitro and in vivo. In the present study we examined the neuroprotective effects of long-term dietary supplementation with resveratrol in mice on behavioral, neurochemical and cerebrovascular level. We report a preserved cognitive function in resveratrol-treated aging mice, as shown by an enhanced acquisition of a spatial Y-maze task. This was paralleled by a higher microvascular density and a lower number of microvascular abnormalities in comparison to aging non-treated control animals. We found no effects of resveratrol supplementation on cholinergic cell number or fiber density. The present findings support the hypothesis that resveratrol exerts beneficial effects on the brain by maintaining cerebrovascular health. Via this mechanism resveratrol can contribute to the preservation of cognitive function during aging

Grouping of orally ingested silica nanomaterials via use of an integrated approach to testing and assessment to streamline risk assessment

Background: Nanomaterials can exist in different nanoforms (NFs). Their grouping may be supported by the formulation of hypotheses which can be interrogated via integrated approaches to testing and assessment (IATA). IATAs are decision trees that guide the user through tiered testing strategies (TTS) to collect the required evidence needed to accept or reject a grouping hypothesis. In the present paper, we investigated the applicability of IATAs for ingested NFs using a case study that includes different silicon dioxide, SiO2 NFs. Two oral grouping hypotheses addressing local and systemic toxicity were identified relevant for the grouping of these NFs and verified through the application of oral IATAs. Following different Tier 1 and/or Tier 2 in vitro methods of the TTS (i.e., in vitro dissolution, barrier integrity and inflammation assays), we generated the NF datasets. Furthermore, similarity algorithms (e.g., Bayesian method and Cluster analysis) were utilized to identify similarities among the NFs and establish a provisional group(s). The grouping based on Tier 1 and/or Tier 2 testing was analyzed in relation to available Tier 3 in vivo data in order to verify if the read-across was possible and therefore support a grouping decision. Results: The measurement of the dissolution rate of the silica NFs in the oro-gastrointestinal tract and in the lysosome identified them as gradually dissolving and biopersistent NFs. For the local toxicity to intestinal epithelium (e.g. cytotoxicity, membrane integrity and inflammation), the biological results of the gastrointestinal tract models indicate that all of the silica NFs were similar with respect to the lack of local toxicity and, therefore, belong to the same group; in vivo data (although limited) confirmed the lack of local toxicity of NFs. For systemic toxicity, Tier 1 data did not identify similarity across the NFs, with results across different decision nodes being inconsistent in providing homogeneous group(s). Moreover, the available Tier 3 in vivo data were also insufficient to support decisions based upon the obtained in vitro results and relating to the toxicity of the tested NFs. Conclusions: The information generated by the tested oral IATAs can be effectively used for similarity assessment to support a grouping decision upon the application of a hypothesis related to toxicity in the gastrointestinal tract. The IATAs facilitated a structured data analysis and, by means of the expert’s interpretation, supported read-across with the available in vivo data. The IATAs also supported the users in decision making, for example, reducing the testing when the grouping was well supported by the evidence and/or moving forward to advanced testing (e.g., the use of more suitable cellular models or chronic exposure) to improve the confidence level of the data and obtain more focused information