In vivo antimalarial activity of the ethanolic leaf extract of Hyptis suaveolens poit on Plasmodium berghei in Mice

The ethanolic leaf extract of Hyptis suaveolens was evaluated for antimalarial activity against Plasmodium berghei in infected mice. In the 4 day suppressive test, 60 male and female albino mice (weight: 18-23 g) were infected and treatment began immediately (Day 0), while administration started 72 hours post infection in the curative test. For each test, mice were divided into 5 groups of 12 animals; each group was administered one of the following: 10 mg/kg, 25 mg/kg and 50 mg/kg of the crude extract, 5 mg/kg of chloroquine phosphate or 0.2 ml normal saline for four consecutive days. Thin blood smears were prepared and examined microscopically under x 100 objective on day 4 to day 7 and the percentage parasitaemia were recorded. On day 7 the red blood cells (RBC), white blood cells (WBC), haemoglobin (Hb) and packed cell volume (PCV) were evaluated. The extract demonstrated dose-dependent inhibition effect on the parasites with 42.76% and 18.03% at 50 mg/kg, 33.69% and 10.22% at 25 mg/kg for suppressive and curative tests respectively, while at 10 mg/kg, 22.39% and 6.06% suppression were recorded in the suppressive and curative tests respectively. The RBC, HB and PCV values decreased while there was an increase in WBC compared with that of the control.Keywords: Hyptis suaveolens, Malaria, Screening, Rodent

Anti-Trypanosomal Potential Of Momordica Balsamina Linn Fruit Pulp Extract Against Trypanosoma brucei brucei Infection

The search for new trypanocides has not been keenly pursued due to high cost of design and development with no promise of financial returns. Momordica balsamina fruit pulp extract was screened for antitrypanosomal activity in experimental Trypanosoma brucei brucei infection in rabbits. The extract was administered prior to parasite inoculation, 24 hours post parasite inoculation and on establishment of infection. The treatment was by oral administration of the extract at 500mg/kg body weight for 14 consecutive days. Parasitaemia was monitored daily while body weight and packed cell volume (PCV) were determined before commencement of studies and subsequently at weekly intervals for 28 days. The result showed a significant (

The Effect of Garlic Extracts on Experimental Trypanosoma brucei brucei Infection of Rabbits.

The anti-trypanosomal effect of aqueous and methanolic extracts of garlic were studied in Trypanosoma brucei brucei infected rabbits. With the establishment of infection, parasitaemia, anaemia, leucopenia, neutropenia and lymphocytosis developed. There was decrease in total serum protein, albumin and increase in cholesterol concentration. Treatment with aqueous and methanolic extracts of garlic had no significant effect on parasitaemia (p>0.05). Anaemia, leucopenia, neutropenia and lymphocytosis persisted. Administration of garlic extracts significantly elevated (