64 research outputs found
Saddle-like, Ï-conjugated, cyclooctatetrathiophene-based, hole-transporting material for perovskite solar cells
Improved Selective Class i HDAC and Novel Selective HDAC3 Inhibitors: Beyond Hydroxamic Acids and Benzamides
The application of class I HDAC inhibitors as cancer therapies is well established, but more recently their development for nononcological indications has increased. We report here on the generation of improved class I selective human HDAC inhibitors based on an ethylketone zinc binding group (ZBG) in place of the hydroxamic acid that features the majority of HDAC inhibitors. We also describe a novel set of HDAC3 isoform selective inhibitors that show stronger potency and selectivity than the most commonly used HDAC3 selective tool compound RGFP966. These compounds are again based on an alternative ZBG with respect to the ortho-anilide that is featured in HDAC3 selective compounds reported to date
A Trapezoidal Octacyanoquinoid Acceptor Forms Solution and Surface Products by Antiparallel Shape Fitting with Conformational Dipole Momentum Switch
Fingerprints of Through-Bond and Through-Space Exciton and Charge Ï-Electron Delocalization in Linearly Extended [2.2]Paracyclophanes
New stilbenoid and
thiophenic compounds terminally functionalized
with donorâdonor, acceptorâacceptor, or donorâacceptor
moieties and possessing a central [2.2]Âparacyclophane unit have been
prepared, and their properties interpreted in terms of through-bond
and through space Ï-electron delocalization (i.e., Ï-conjugations).
Based on photophysical data, their excited-state properties have been
described with a focus on the participation of the central [2.2]Âparacyclophane
in competition with through-bond conjugation in the side arms. To
this end, two-photon and one-photon absorption and emission spectroscopy,
as a function of temperature, solvent polarity, and pressure in the
solid state have been recorded. Furthermore, charge delocalization
through the [2.2]Âparacyclophane in the neutral state and in the oxidized
species (radical cations, dications and radical trications) has been
investigated, allowing the elucidation of the vibrational Raman fingerprint
of through-space charge delocalization. Thus, a complementary approach
to both âintermolecularâ excitation and charge delocalizations
in [2.2]Âparacyclophane molecules is shown which can serve as models
of charge and exciton migration in organic semiconductors
Identification and characterization of antibacterial compound(s) of cockroaches (Periplaneta americana)
Infectious diseases remain a significant threat to human health, contributing to more than 17 million deaths, annually. With the worsening trends of drug resistance, there is a need for newer and more powerful antimicrobial agents. We hypothesized that animals living in polluted environments are potential source of antimicrobials. Under polluted milieus, organisms such as cockroaches encounter different types of microbes, including superbugs. Such creatures survive the onslaught of superbugs and are able to ward off disease by producing antimicrobial substances. Here, we characterized antibacterial properties in extracts of various body organs of cockroaches (Periplaneta americana) and showed potent antibacterial activity in crude brain extract against methicillin-resistant Staphylococcus aureus and neuropathogenic E. coli K1. The size-exclusion spin columns revealed that the active compound(s) are less than 10 kDa in molecular mass. Using cytotoxicity assays, it was observed that pre-treatment of bacteria with lysates inhibited bacteria-mediated host cell cytotoxicity. Using spectra obtained with LC-MS on Agilent 1290 infinity liquid chromatograph, coupled with an Agilent 6460 triple quadruple mass spectrometer, tissues lysates were analyzed. Among hundreds of compounds, only a few homologous compounds were identified that contained isoquinoline group, chromene derivatives, thiazine groups, imidazoles, pyrrole containing analogs, sulfonamides, furanones, flavanones, and known to possess broad-spectrum antimicrobial properties, and possess anti-inflammatory, anti-tumour, and analgesic properties. Further identification, characterization and functional studies using individual compounds can act as a breakthrough in developing novel therapeutics against various pathogens including superbugs
[2,2']paracyclophane-based Ï-conjugated molecular wires reveal molecular-junction behavior
Discovery of 4-((1-(1H-imidazol-2-yl)alkoxy)methyl)pyridines as a new class of Trypanosoma cruzi growth inhibitors
The identification of a new series of growth inhibitors of Trypanosoma cruzi, the causative agent of Chagasâ disease, is described. In vitro screening of a subset of compounds from our in-house compound collection against the parasite led to the identification of hit compound 1 with low micromolar inhibition of T. cruzi growth. SAR exploration on the hit compound led to the identification of compounds that show nanomolar parasite growth inhibition (T. cruzi EC50 †100 nM) and no cytotoxicity in human cells (HeLa CC50 > 50 ÎŒM). Further investigation identified CYP51 inhibition (compound 11 CYP51 IC50 52 nM) as a possible mechanism of action of this new class of anti-parasitic agents
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