Literatuurstudie risicojongeren: onderwijs, arbeid, zorg en veiligheid

De Directie Jeugd & Onderwijs Rotterdam wil graag meer inzicht krijgen in de definitie van de groep risicojongeren, de precieze omvang van deze groep, de aard van de problematiek en de mogelijke oplossingen. Bovendien heeft de Directie Jeugd en Onderwijs Rotterdam behoefte aan wetenschappelijk inzicht in de (on)mogelijkheden van een integrale benadering van risicojongeren. In opdracht van de Directie Jeugd en Onderwijs Rotterdam heeft de Kenniswerkplaats Rotterdams Talent (KWP) voorliggende studie uitgevoerd naar de problematiek en aanpak van risicojongeren in Rotterda

Turning over a New Leaf : precision medicine in oncology guided by circulating tumor cell counts and characteristics

Many new treatments have been put on the market over the past decades, but have been proven to be effective in only 20-50% of the patients. To improve the prognosis of patients with cancer and in order to keep cancer care affordable, it will be important to select effective treatments for individual patients up-front. To avoid the risks and discomfort of tissue biopsies as well as to account for heterogeneity between tumor locations, blood sampling for circulating tumor cells may aid as a liquid biopsy. In this thesis, the possibilities and clinical relevance of the use of a liquid biopsy by the characterization of CTCs for patients with metastatic breast, prostate and colorectal cancer are described. The studies in this the

Evaluating and Improving Teacher Educators’ Language-Oriented Performance in Content-Based Teaching

In general, teacher educators are considered to be educational specialists whose main task is to communicate content-based concepts to prospective teachers. However, unfortunately, most studies on teacher professional development overlook this specific language-oriented aspect of content-based teaching. Therefore, we address the aforementioned research gap and argue that teacher educators’ evaluation of their language-oriented performance in educational communication enhances the quality of their content-based teaching. Accordingly, we examine how the language-oriented performance of teacher educators is evaluated by both individual teacher educators (sample size N=3) and their students (N=32) in a small-scale intervention study. The findings of the study reveal that there is a relationship between the order of application of five language focus areas (i.e., language awareness, active listening, formalizing interaction, language support, and language and learning development, as noticed by the students), and teacher educators’ ability to apply these areas in accordance with their objectives related to content-based teaching

Hip and knee replacement patients prefer pen-and-paper questionnaires : implications for future patient-reported outcome measure studies

Analysis and Stochastic

Prognostic Impact of HER2 and ER Status of Circulating Tumor Cells in Metastatic Breast Cancer Patients with a HER2-Negative Primary Tumor

AbstractBACKGROUND: Preclinical and clinical studies have reported that human epidermal growth factor receptor 2 (HER2) overexpression yields resistance to endocrine therapies. Here the prevalence and prognostic impact of HER2-positive circulating tumor cells (CTCs) were investigated retrospectively in metastatic breast cancer (MBC) patients with a HER2-negative primary tumor receiving endocrine therapy. Additionally, the prevalence and prognostic significance of HER2-positive CTCs were explored in a chemotherapy cohort, as well as the prognostic impact of the estrogen receptor (ER) CTC status in both cohorts. METHODS: Included were MBC patients with a HER2-negative primary tumor, with ≥1 detectable CTC, starting a new line of treatment. CTCs were enumerated using the CellSearch system, characterized for HER2 with the CellSearch anti-HER2 phenotyping reagent, and characterized for ER mRNA expression. Primary end point was progression-free rate after 6 months (PFR6months) of endocrine treatment in HER2-positive versus HER2-negative CTC patients. RESULTS: HER2-positive CTCs were present in 29% of all patients. In the endocrine cohort (n=72), the PFR6months was 53% for HER2-positive versus 68% for HER2-negative CTC patients (P=.23). In the chemotherapy cohort (n=82), no prognostic value of HER2-positive CTCs on PFR6months was observed either. Discordances in ER status between the primary tumor and CTCs occurred in 25% of all patients but had no prognostic value in exploratory survival analyses. CONCLUSION: Discordances regarding HER2 status and ER status between CTCs and the primary tumor occurred frequently but had no prognostic impact in our MBC patient cohorts