686 research outputs found
Recurrent episodes of Takotsubo cardiomyopathy in systemic sclerosis
Systemic sclerosis is an autoimmune disease characterized by fibrosis and small vessel vasculopathy, which affects various organ systems, such as the heart. Takotsubo cardiomyopathy is a transient cardiomyopathy in reaction to an emotional or physical trigger. There may be clinical and pathogenetic overlap between Takotsubo cardiomyopathy and primary systemic sclerosis heart disease, and some patients with systemic sclerosis have been diagnosed with recurrent Takotsubo cardiomyopathy. Our large systemic sclerosis clinical cohort was reviewed to identify cases diagnosed with Takotsubo cardiomyopathy. The clinical features, laboratory and imaging results were reviewed and evaluated to perform a comparison between cases. We identified five patients with systemic sclerosis, all female (age 68.6â±â5.7âyears), who were diagnosed with Takotsubo cardiomyopathy. Two of these patients had recurrent episodes: one case with a history of multiple episodes and the other with one recurrence. Typical features included repolarization abnormalities on the electrocardiogram and transient left ventricular dysfunction observed using echocardiography or cardiac magnetic resonance imaging. Our findings build upon previous reports and observations that systemic sclerosis may cause Takotsubo cardiomyopathy. To our knowledge, this is the largest case series of Takotsubo syndrome in patients with systemic sclerosis. This association may provide novel insights into the aetiopathogenesis of Takotsubo cardiomyopathy as part of primary systemic sclerosis heart involvement
A Multi-wavelength View of the TeV Blazar Markarian 421: Correlated Variability, Flaring, and Spectral Evolution
We report results from a multi-wavelength monitoring campaign on Mrk 421 over
the period of 2003-2004. The source was observed simultaneously at TeV and
X-ray energies, with supporting observations frequently carried out at optical
and radio wavelengths. The large amount of simultaneous data has allowed us to
examine the variability of Mrk 421 in detail. The variabilities are generally
correlated between the X-ray and gamma-ray bands, although the correlation
appears to be fairly loose. The light curves show the presence of flares with
varying amplitudes on a wide range of timescales both at X-ray and TeV
energies. Of particular interest is the presence of TeV flares that have no
coincident counterparts at longer wavelengths, because the phenomenon seems
difficult to understand in the context of the proposed emission models for TeV
blazars. We have also found that the TeV flux reached its peak days before the
X-ray flux during a giant flare in 2004. Such a difference in the development
of the flare presents a further challenge to the emission models. Mrk 421
varied much less at optical and radio wavelengths. Surprisingly, the normalized
variability amplitude in optical seems to be comparable to that in radio,
perhaps suggesting the presence of different populations of emitting electrons
in the jet. The spectral energy distribution (SED) of Mrk 421 is seen to vary
with flux, with the two characteristic peaks moving toward higher energies at
higher fluxes. We have failed to fit the measured SEDs with a one-zone SSC
model; introducing additional zones greatly improves the fits. We have derived
constraints on the physical properties of the X-ray/gamma-ray flaring regions
from the observed variability (and SED) of the source. The implications of the
results are discussed. (Abridged)Comment: 32 pages, 12 figures, to appear in Ap
Evidence for proton acceleration up to TeV energies based on VERITAS and Fermi-LAT observations of the Cas A SNR
We present a study of -ray emission from the core-collapse supernova
remnant Cas~A in the energy range from 0.1GeV to 10TeV. We used 65 hours of
VERITAS data to cover 200 GeV - 10 TeV, and 10.8 years of \textit{Fermi}-LAT
data to cover 0.1-500 GeV. The spectral analysis of \textit{Fermi}-LAT data
shows a significant spectral curvature around GeV that is
consistent with the expected spectrum from pion decay. Above this energy, the
joint spectrum from \textit{Fermi}-LAT and VERITAS deviates significantly from
a simple power-law, and is best described by a power-law with spectral index of
with a cut-off energy of TeV. These
results, along with radio, X-ray and -ray data, are interpreted in the
context of leptonic and hadronic models. Assuming a one-zone model, we exclude
a purely leptonic scenario and conclude that proton acceleration up to at least
6 TeV is required to explain the observed -ray spectrum. From modeling
of the entire multi-wavelength spectrum, a minimum magnetic field inside the
remnant of is deduced.Comment: 33 pages, 9 Figures, 6 Table
A Search for TeV Gamma-Ray Emission from High-Peaked Flat Spectrum Radio Quasars Using the Whipple Air-Cherenkov Telescope
Blazars have traditionally been separated into two broad categories based
upon their optical emission characteristics; BL Lacs, with faint or no emission
lines, and flat spectrum radio quasars (FSRQs) with prominent, broad emission
lines. The spectral energy distribution of FSRQs has generally been thought of
as being more akin to the low-peaked BL Lacs, which exhibit a peak in the
infrared region of the spectrum, as opposed to high-peaked BL Lacs (HBLs),
which exhibit a peak in UV/X-ray region of the spectrum. All blazars currently
confirmed as sources of TeV emission are HBLs. Recent surveys have found
several FSRQs exhibiting spectral properties similar to HBLs, particularly the
synchrotron peak frequency. These objects are potential sources of TeV emission
according to several models of blazar jet emission and blazar evolution.
Measurements of TeV flux or upper limits could impact existing theories
explaining the links between different blazar types and could have a
significant impact on our understanding of the nature of objects that are
capable of TeV emission. In particular, the presence (or absence) of TeV
emission from FSRQs could confirm (or cast doubt upon) recent evolutionary
models that expect intermediate objects in a transitionary state between FSRQ
and BL Lac. The Whipple 10 meter imaging air-Cherenkov gamma-ray telescope is
well suited for TeV gamma-ray observations. Using the Whipple telescope, we
have taken data on a small selection of nearby(z<0.1 in most cases),
high-peaked FSRQs. Although one of the objects, B2 0321+33, showed marginal
evidence of flaring, no significant emission was detected. The implications of
this paucity of emission and the derived upper limits are discussed.Comment: accepted for publication in Astrophysical Journa
Direct measurement of stellar angular diameters by the VERITAS Cherenkov Telescopes
The angular size of a star is a critical factor in determining its basic
properties. Direct measurement of stellar angular diameters is difficult: at
interstellar distances stars are generally too small to resolve by any
individual imaging telescope. This fundamental limitation can be overcome by
studying the diffraction pattern in the shadow cast when an asteroid occults a
star, but only when the photometric uncertainty is smaller than the noise added
by atmospheric scintillation. Atmospheric Cherenkov telescopes used for
particle astrophysics observations have not generally been exploited for
optical astronomy due to the modest optical quality of the mirror surface.
However, their large mirror area makes them well suited for such
high-time-resolution precision photometry measurements. Here we report two
occultations of stars observed by the VERITAS Cherenkov telescopes with
millisecond sampling, from which we are able to provide a direct measurement of
the occulted stars' angular diameter at the milliarcsecond scale.
This is a resolution never achieved before with optical measurements and
represents an order of magnitude improvement over the equivalent lunar
occultation method. We compare the resulting stellar radius with empirically
derived estimates from temperature and brightness measurements, confirming the
latter can be biased for stars with ambiguous stellar classifications.Comment: Accepted for publication in Nature Astronom
A consistent treatment for pion form factors in space-like and time-like regions
We write down some relevant matrix elements for the scattering and decay
processes of the pion by considering a quark-meson vertex function. The pion
charge and transition form factors , , and
are extracted from these matrix elements using a relativistic
quark model on the light-front. We found that, the form factors and
in the space-like region agree well with experiment.
Furthermore, the branching ratios of all observed decay modes of the neutral
pion, that are related to the form factors and
in the time-like region, are all consistent with the data as
well. Additionally, in the time-like region, which deals with the
nonvalence contribution, is also discussed.Comment: 24 pages, 6 figures, to appear in Phys. Rev.
Gamma-ray Observations Under Bright Moonlight with VERITAS
Imaging atmospheric Cherenkov telescopes (IACTs) are equipped with sensitive
photomultiplier tube (PMT) cameras. Exposure to high levels of background
illumination degrades the efficiency of and potentially destroys these
photo-detectors over time, so IACTs cannot be operated in the same
configuration in the presence of bright moonlight as under dark skies. Since
September 2012, observations have been carried out with the VERITAS IACTs under
bright moonlight (defined as about three times the night-sky-background (NSB)
of a dark extragalactic field, typically occurring when Moon illumination >
35%) in two observing modes, firstly by reducing the voltage applied to the
PMTs and, secondly, with the addition of ultra-violet (UV) bandpass filters to
the cameras. This has allowed observations at up to about 30 times previous NSB
levels (around 80% Moon illumination), resulting in 30% more observing time
between the two modes over the course of a year. These additional observations
have already allowed for the detection of a flare from the 1ES 1727+502 and for
an observing program targeting a measurement of the cosmic-ray positron
fraction. We provide details of these new observing modes and their performance
relative to the standard VERITAS observations
Dark Matter Constraints from a Joint Analysis of Dwarf Spheroidal Galaxy Observations with VERITAS
We present constraints on the annihilation cross section of WIMP dark matter
based on the joint statistical analysis of four dwarf galaxies with VERITAS.
These results are derived from an optimized photon weighting statistical
technique that improves on standard imaging atmospheric Cherenkov telescope
(IACT) analyses by utilizing the spectral and spatial properties of individual
photon events. We report on the results of 230 hours of observations of
five dwarf galaxies and the joint statistical analysis of four of the dwarf
galaxies. We find no evidence of gamma-ray emission from any individual dwarf
nor in the joint analysis. The derived upper limit on the dark matter
annihilation cross section from the joint analysis is at 1 TeV for the bottom quark () final state,
at 1 TeV for the tau lepton
() final state and at 1 TeV for the gauge boson () final state.Comment: 14 pages, 9 figures, published in PRD, Ascii tables containing
annihilation cross sections limits are available for download as ancillary
files with readme.txt file description of limit
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