Recovery of Hearing in Cisplatin-Induced Ototoxicity in the Guinea Pig with Intratympanic Dexamethasone

The purpose of this study was to investigate the effectiveness of intratympanic dexamethasone injection as a therapeutic agent against cisplatin-induced ototoxicity. Animals were randomly divided into three groups. Group one received intraperitoneal cisplatin alone, group two, received intratympanic dexamethasone after cisplatin ototoxicity had been demonstrated. Group three, which is control group, received intratympanic dexamethasone.Then we made three measurements. First we measured the baseline distortion product otoacustic emission (DPOAEs) of all the guine pigs. Second we injected cisplatin intraperitoneal group one and two the same day. Third we measured DPOAEs after 72 h of group one and two. Moreover DPOAEs were measured at the end of the first and second week only in group two. Cochleae were harvested and processed for electron microscopy after then. Values of The DPOAEs amplitudes and signal-to-noise ratio (SNR) at 1-6 kHz frequencies for group 1 after the injections significantly decreased over those before injections (P 0.05). In group 2, the DPOAEs measurements were close to significance at the end of the second week (P = 0.056). Intratympanic dexamethasone injection did not cause any ototoxic effect. Although intratympanic dexamethasone did not reach the statistically significant results, the measurements were close to significance. Intratympanic dexamethasone might have a significant therapeutic effect after cisplatin ototoxicity with different dose and application regimens

Protective Effect of Methylprednisolone Against Cisplatin-induced Ototoxicity: Comparison of Route of Administration

Objective: We investigated the otoprotective effect of methylprednisolone against cisplatin-induced ototoxicity by comparing the effectiveness of route of administration

Histopathologic parameters in chronic rhinosinusitis with nasal polyposis: impact on quality of life outcomes

BackgroundChronic rhinosinusitis (CRS) is a common disease with a significant impact on health-related quality of life (QOL) of the patient. Histologic inflammatory markers in CRS are an important marker in determining the severity of the disease. In this study, we evaluated the association of histopathologic parameters with QOL questionnaires in patients with CRS with nasal polyposis after endoscopic sinus surgery (ESS)

Predictors of neck metastasis in early stage oral cavity cancer

Objective: To identify the effects of clinical and histopathological parameters on neck metastasis in early-stage oral cavity cancers

Effectiveness of Royal Jelly on Tympanic Membrane Perforations: An Experimental Study

WOS: 000207462800019PubMed ID: 19128609Objective: The aim of this study was to evaluate the comparison of the efficacy of royal jelly in a guinea pig tympanic membrane perforation model with untreated and control groups. Study Design: Prospective study using 16 adult guinea pigs. Methods: Each animal underwent subtotal removal of the tympanic membrane in one ear. Animals were divided into two groups of eight animals each. Group A was treated with topical royal jelly, and group B was treated with saline. All opposite right ears were used as the control group. Examination was done by otoendoscopy on days 10, 12, and 14. The healing process was observed under the microscope and photographed for 3 months. Results: There was no significant difference between group A and group B in the incidence of perforation closure. However, after 3 months, the mean thickness of the tympanic membranes was 0.11, 0.07, and 0.08 mm, respectively, in group A, group B, and the control. These results showed a statistically significant difference. Histologically, the tympanic membranes of group A showed marked fibroblastic orientation and well-organized connective tissue. Application of royal jelly improved the success rate of closure, as shown in the present study. Conclusions: This is the first study to investigate the effectiveness of royal jelly in enhancing healing in tympanic membrane perforations. Our study suggests that royal jelly is effective in increasing healing of tympanic membrane perforations in guinea pigs

THE COVID-19 PANDEMIC AND ARTIFICIAL INTELLIGENCE (AI) APPLICATIONS IN HEALTH: HOW MUCH ARE WE INTERESTED IN?

Purpose: New viruses have emerged, causing global damage and mass deaths that can spread to international borders, the latest of which is the new coronavirus (COVID-19). After the Second International Congress on Artificial Intelligence in Health, themed "Artificial Intelligence in Health During COVID-19 Pandemic Process" organized online by Izmir Bakircay University and Izmir Provincial Health Directorate with the contributions of the International Association of Artificial Intelligence in Health, a questionnaire was conducted to evaluate the knowledge of the participants about artificial intelligence applications.Material and Methods: This study aimed to evaluate the interest of the congress participants in this field with the questions which form the questionnaire such as the duration of the interest of the participants in the field of artificial intelligence in health, their publication status, the development of studies on artificial intelligence with the COVID-19 pandemic, demographic structures such as age and gender, and educational level. 130 participants answered the questionnaire consisting of 23 questions. Questionnaire responses were analyzed in a statistical setting.Results: We found that 130 people filled out the questionnaire and the majority of the participants were female, with participation from many organizations, but university staff showed more interest. We have seen that the 30-39 age group is more interested in artificial intelligence than the other age groups, but the majority of the participants do not have academic studies in this field. We found that the technical terms related to artificial intelligence were not well known by the participants, and that the number of participants who tended to this field, especially in the recent year, was high. Another important point was that people working in this field stated that they would definitely follow up if scientific activities continued.Conclusion: We know how important congresses, symposiums, courses and other meetings are, especially for scientist candidates, which will be held to raise awareness about the usage areas of artificial intelligence-based health technologies, to develop new communication and work networks by bringing together different disciplines, to create an agenda and to lay the groundwork for new studies, and we think that there is a need for many repetitive activities in this field and that these activities should be continued