Phyllodes tumor of the breast in an adolescent girl

Phyllodes tumor (PT) is an uncommon tumor in adolescent girls and young women. A case of PT in a 14-year-old girl is reported. The clinical examination showed a painless tumor that had grown during 10 months. Total excision of the mass with wide margin was performed. The diagnosis, behavior, and treatment of this rare tumor are discussed

DOES PERITUMORAL LYVE-1 IMMUNOREACTIVITY PREDICT THE SENTINEL LYMPH NODE METASTASIS?

LYVE-1 is a -recently identified- selective lymphatic endothelial surface receptor which plays mainly role on transportation of hyaluronan from extracellular matrix to the regional lymph nodes. In a few cancer studies, relationships between LYVE-1/Hyaluronan and lymphatic invasion and metastasis has been shown. However, predictive values of peritumoral or intratumoral LYVE-1 positivity for the assesment of regional lymphatic invasion is unknown. In the present study, we aimed to investigate whether the peri/intratumoral LYVE-1 immunoreactivity related to sentinel lymph node status in 25 breast-cancer-patients. Sentinel lymph node (SLN) biopsy was performed by using combined technique with vital blue dye and hand-held gamma probe dedection in patients with early breast cancer. Lymphoscintigraphy was performed in all patients. Metastases to sentinel lymph nodes was evaluated both Hematoxylene/Eosine (HE) and immunohistochemical (IHC) staining. Serial sections which contain both invasive tumor and peri-tumoral area from the original block were cut (4 um) and stained with HE and LYVE-1. "LYVE1 antibody-lymphatic vessel marker" was used for IHC analysis. The sensitivity and specifity of the method were established as 67% and 71% respectively. The LYVE-1 positivity was mostly peritumoral (85 %) Negative and positive predictive values of LYVE-1 immunostaining were 77% and 60% respectively. On conlusion, as a novel lymphangiogenesis marker LYVE-1, has limited predictive values for the evaluation of sentinel lymph node metastasis in patients with early breast cancer

Psychosexual and body image aspects of quality of life in turkish breast cancer patients: a comparison of breast conserving treatment and mastectomy

Aims and background. Assessing psychosexual and body image aspects of quality of life in Turkish breast cancer patients treated by either mastectomy or breast conserving treatment (BCT)

Psychosexual and Body Image Aspects of Quality of Life in Turkish Breast Cancer Patients: A Comparison of Breast Conserving Treatment and Mastectomy

Aims and background. Assessing psychosexual and body image aspects of quality of life in Turkish breast cancer patients treated by either mastectomy or breast conserving treatment (BCT)

Pathologic Nipple Discharge in Patients with Radiologically Invisible Mass: Review of 28 Consecutive Sub-areolar Explorations

The carcinoma frequency of clinically and radiologically negative pathologic nipple discharges (PNDs) and the optimum management strategy of these cases are still unclear. In this study, the frequency of cancer and the situation of the classic surgical intervention in patients with PND and invisible mammographic and ultrasonographic results are reviewed. The data pertaining to the cases of sub-areolar exploration and major duct excision in a surgery clinic of university hospital from December 2002 to June 2007 have been examined in detail. In 28 cases with PND, which did not have any findings during conventional radiologic examinations, 21% of cases had malignant, and 7% of cases had atypical ductal hyperplasia. The frequency of invasive or in situ carcinoma is not low in clinically and radiologically negative PNDs. Sub-areolar exploration and major duct excision seems to be an appropriate and definitive diagnostic and therapeutic option in this special patient group

Papillary Thyroid Carcinoma Mimicking Anaplastic Thyroid Carcinoma Following Fine-Needle Aspiration Biopsy

Background: Cutaneous metastases from well-differentiated thyroid carcinomas are rare and usually identified in patients with widely disseminated disease. Fine-needle aspiration biopsy (FNAB) has become an acceptable method for the assessment of thyroid nodules. Very rarely needle track dissemination of tumor cells in the thyroid nodule occurs, but, when this occurs, it is evident many years after the FNAB. We report a patient who appears to have tumor dissemination from an FNAB needle track only 4 months after the procedure

Metastatic tumors in the breast: a report of 5 cases and review of the literature.

Breast cancer is the most common malignacy in women. However metastases to the breast from non-mammary malignant neoplasms are rare and were detected at a rate of 0.28% in our series. Clinical and pathologic findings in 5 cases of metastatic tumors (malign mesenchymal tumor, squamous cell carcinoma of the tongue, non-Hodgkin lymphoma, and Sezary syndrome) in the breast are presented and discussed with respect to the literature. Detailed clinical history and a multidisciplinary approach are useful in establishing correct diagnosis and preventing unnecessary radical surgery

Validation of Three Breast Cancer Nomograms and a New Formula for Predicting Non-sentinel Lymph Node Status

Background: The aim of the study was to evaluate the available breast nomograms (MSKCC, Stanford, Tenon) to predict non-sentinel lymph node metastasis (NSLNM) and to determine variables for NSLNM in SLN positive breast cancer patients in our population. Materials and Methods: We retrospectively reviewed 170 patients who underwent completion axillary lymph node dissection between Jul 2008 and Aug 2010 in our hospital. We validated three nomograms (MSKCC, Stanford, Tenon). The likelihood of having positive NSLNM based on various factors was evaluated by use of univariate analysis. Stepwise multivariate analysis was applied to estimate a predictive model for NSLNM. Four factors were found to contribute significantly to the logistic regression model, allowing design of a new formula to predict non-sentinel lymph node metastasis. The AUCs of the ROCs were used to describe the performance of the diagnostic value of MSKCC, Stanford, Tenon nomograms and our new nomogram. Results: After stepwise multiple logistic regression analysis, multifocality, proportion of positive SLN to total SLN, LVI, SLN extracapsular extention were found to be statistically significant. AUC results were MSKCC: 0.713/Tenon: 0.671/Stanford: 0.534/DEU: 0.814. Conclusions: The MSKCC nomogram proved to be a good discriminator of NSLN metastasis in SLN positive BC patients for our population. Stanford and Tenon nomograms were not as predictive of NSLN metastasis. Our newly created formula was the best prediction tool for discriminate of NSLN metastasis in SLN positive BC patients for our population. We recommend that nomograms be validated before use in specific populations, and more than one validated nomogram may be used together while consulting patients