8 research outputs found
An explanatory mixed methods study on the validity and validation of students’ assessment results in the undergraduate surgery course
<p><b>Background/purpose:</b> There is inadequate evidence of reported validity of the results of assessment instruments used to assess clinical competence. This study aimed at combining multiple lines of quantitative and qualitative evidence to support interpretation and use of assessment results.</p> <p><b>Method:</b> This study is a mixed methods explanatory research set in two stages of data collection and analysis (QUAN : qual). Guided by Messick’s conceptual model, quantitative evidences as reliability and correlation coefficients of various validity components were calculated using students’ scores, grades and success rates of the whole population of students in 2012/2013 and 2013/2014 (<i>n</i>= 383; 326). The underlying values that scaffold validity evidences were identified via Focus Group Discussions (FGD) with faculty and students; sampling technique was purposive; and results were analyzed by content analysis.</p> <p><b>Results:</b> (1) Themes that resulted from content analysis aligned with quantitative evidences. (2) Assessment results showed: (a) content validity (table of specifications and blueprinting in another study); (b) consequential validity (positive unintended consequences resulted from new assessment approach); (c) relationships to other variables [a statistically significant correlation among various assessment methods; with combined score (0.64–0.86) and between mid and final exam results (<i>r</i> = 0.672)]; (d) internal consistency (high reliability of MCQ and OSCE: 0.81, 0.80); (3) success rates and grades distribution alone could not provide evidence to advocate an argument on validity of results.</p> <p><b>Conclusion:</b> The unified approach pursued in this study created a strong evidential basis for meaningful interpretation of assessment scores that could be applied in clinical assessments.</p
Pedigree analysis of a three-generation consanguineous family presenting with autosomal recessive inheritance of celiac disease.
<p>Exome sequenced individuals are indicated with an * mark.</p
Genotype and allelic distribution of <i>AK5</i>,c.1683_1684insATT variant between celiac sporadic patients and controls, as well as their risk prediction for celiac disease.
<p>Genotype and allelic distribution of <i>AK5</i>,c.1683_1684insATT variant between celiac sporadic patients and controls, as well as their risk prediction for celiac disease.</p
Whole exome sequencing of a consanguineous family identifies the possible modifying effect of a globally rare <i>AK5</i> allelic variant in celiac disease development among Saudi patients - Fig 3
<p>(A) Nucleotide sequence Alignment of human and primate adenylate kinase 5 genes. (B) Phylogenetic tree of the human adenylate kinases.</p
The genetic variants yield of a celiac disease family.
<p>The genetic variants yield of a celiac disease family.</p
Molecular view of wildtype (Red in color) and mutant (Yellow in color) AK5: a) Hydrophobic bonds arrangement in AK5-wildtype residues Iso561 with Iso556 and Ala557 and b) AK5-mutant residues Iso562 and Phe563.
<p>Molecular view of wildtype (Red in color) and mutant (Yellow in color) AK5: a) Hydrophobic bonds arrangement in AK5-wildtype residues Iso561 with Iso556 and Ala557 and b) AK5-mutant residues Iso562 and Phe563.</p
List of nucleotide variants from exome data which showed autosomal recessive inheritance model in consanguineous celiac disease family.
<p>List of nucleotide variants from exome data which showed autosomal recessive inheritance model in consanguineous celiac disease family.</p
Chromosomal location of human <i>AK5</i> gene at 1p31.1 and chromatograms of ATT insertion sequence (wild type, heterozygote, and homozygous mutant genotypes) observed in celiac patients.
<p>(Chromosome and gene location figure generated from Ensembl browser).</p