3 research outputs found
Accelerated directed evolution of dye-decolorizing peroxidase using a bacterial extracellular protein secretion system (BENNY)
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/12/2019
- Field of study
Get PDFBackground
Dye-decolorizing peroxidases (DyPs) are haem-containing peroxidases that show great promises in industrial biocatalysis and lignocellulosic degradation. Through the use of Escherichia coli osmotically-inducible protein Y (OsmY) as a bacterial extracellular protein secretion system (BENNY), we successfully developed a streamlined directed evolution workflow to accelerate the protein engineering of DyP4 from Pleurotus ostreatus strain PC15.
Result
After 3 rounds of random mutagenesis with error-prone polymerase chain reaction (epPCR) and 1 round of saturation mutagenesis, we obtained 4D4 variant (I56V, K109R, N227S and N312S) that displays multiple desirable phenotypes, including higher protein yield and secretion, higher specific activity (2.7-fold improvement in kcat/Km) and higher H2O2 tolerance (sevenfold improvement based on IC50).
Conclusion
To our best knowledge, this is the first report of applying OsmY to simplify the directed evolution workflow and to direct the extracellular secretion of a haem protein such as DyP4
Critical care usage after major gastrointestinal and liver surgery: a prospective, multicentre observational study
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
No full textBackground
Patient selection for critical care admission must balance patient safety with optimal resource allocation. This study aimed to determine the relationship between critical care admission, and postoperative mortality after abdominal surgery.
Methods
This prespecified secondary analysis of a multicentre, prospective, observational study included consecutive patients enrolled in the DISCOVER study from UK and Republic of Ireland undergoing major gastrointestinal and liver surgery between October and December 2014. The primary outcome was 30-day mortality. Multivariate logistic regression was used to explore associations between critical care admission (planned and unplanned) and mortality, and inter-centre variation in critical care admission after emergency laparotomy.
Results
Of 4529 patients included, 37.8% (n=1713) underwent planned critical care admissions from theatre. Some 3.1% (n=86/2816) admitted to ward-level care subsequently underwent unplanned critical care admission. Overall 30-day mortality was 2.9% (n=133/4519), and the risk-adjusted association between 30-day mortality and critical care admission was higher in unplanned [odds ratio (OR): 8.65, 95% confidence interval (CI): 3.51–19.97) than planned admissions (OR: 2.32, 95% CI: 1.43–3.85). Some 26.7% of patients (n=1210/4529) underwent emergency laparotomies. After adjustment, 49.3% (95% CI: 46.8–51.9%, P<0.001) were predicted to have planned critical care admissions, with 7% (n=10/145) of centres outside the 95% CI.
Conclusions
After risk adjustment, no 30-day survival benefit was identified for either planned or unplanned postoperative admissions to critical care within this cohort. This likely represents appropriate admission of the highest-risk patients. Planned admissions in selected, intermediate-risk patients may present a strategy to mitigate the risk of unplanned admission. Substantial inter-centre variation exists in planned critical care admissions after emergency laparotomies
Critical care usage after major gastrointestinal and liver surgery: a prospective, multicentre observational study
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- A. Abdulmajid
- A. Abid
- A. Al-Mousawi
- A. Al-Robeye
- A. Ali
- A. Amajuoyi
- A. Ang
- A. Anilkumar
- A. Aslanyan
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- S.M. Anderson
- S.M. Chiu
- S.M. Choi
- S.M. Lakhani
- S.R. Kosasih
- S.S. Talukdar
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- S.W. McLure
- S.X. Poo
- Saunders
- Sawyer
- Student Audit and Research in Surgery (STARSurg) Collaborative
- Symons
- T. Arif
- T. Axelson
- T. Bergara
- T. Bloomfield
- T. Dogra
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- T. Filipescu
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- T. Kane
- T. Khan
- T. Lewis
- T. Lo
- T. Patel
- T. Pitts-Tucker
- T. Raghvani
- T. Ramtoola
- T. Rangan
- T. Reakes
- T. Reeves
- T. Ross
- T. Sale
- T. Sarvanandan
- T. Sorah
- T. Spencer
- T. Tharmachandirar
- T. Ward
- T. Yang
- T.C. Hoskins
- T.E. Glover
- T.M. Brooks
- T.M. Drake
- T.M. Schulz
- T.M.P. Fung
- T.P. Bemand
- T.P. Pezas
- T.R. Barrow
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- V. Charavanamuttu
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- V. Patel
- V. Raghuvir
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- V. Shatkar
- V. Teng
- V. Thirumal
- V. Wong
- V.C. Wing
- Vester-Andersen
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- Vlayen
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- W. Bolton
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- W. Leung
- W. Liew
- W. Loke
- W.A. Gatfield
- W.C. Soon
- W.M. Wynell-Mayow
- W.W. Chaudhry
- Wong
- Wunsch
- X. Chen
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- Z. Abbas
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