Anti-TLTF antibodies in sera and CSF determined by ELISA.

<p>(a). Concentrations obtained in anti-TLTF ELISA in serum samples of early stage (E, n = 25), intermediate stage (I, n = 25) and late stage (L, n = 24) patients. Differences between E, I and L are not significant from each other but are significant compared to the control (C) samples (p = 0.0002). (b). Concentrations of anti-TLTF in CSF samples of early stage (E, n = 20) patients, intermediate stage (I, n = 21) and late stage (L, n = 20) patients. Note the significant difference between intermediate and early stage (<i>P = 0.0005</i>) and between intermediate and late stage (<i>P<0.05</i>). The levels of TLTF in CSF are represented in (µg/ml). The horizontal hatched line marks the diagnostic cut-off value (2 µg/ml).</p