MFA10 (MFA 2010)

Catalogue of a culminating student exhibition held at the Mildred Lane Kemper Art Museum in 2010. Content includes Foreword / Buzz Spector -- Thinking as making / Robert Gero -- A new set of conversations / Patricia Olynyk -- MFA 2010 graduates. Clyde Ashby / Aaron Bos-Wahl / Andrew Cozzens / John Early / Ryan James Fabel / Joel Fullerton / Mary Beth Hassan / Wenting Hsu / John Nicholas Hutchings/ Dani Kantrowitz / Larry Keaty / Mamie Korpela / Paola Laterza / Mad Mohre / Emily Moorhead / Jonathan Muehlke / Jessa Richardson / Nicolette Ross / Carlie Trosclair / About the Sam Fox School.https://openscholarship.wustl.edu/books/1007/thumbnail.jp

MFA15 (MFA 2015)

Catalogue of a culminating student exhibition held at the Mildred Lane Kemper Art Museum, May 1 - August 2, 2015 . Introduction / Heather Corcoran and Patricia Olynyk -- Diana Casanova / Emily J. Hanson -- Andrea M. Coates : in the operating theater / Stephanie Dering -- Margaux Crump -- Brandon Daniels -- Addoley Dzegede : do you prefer answers or truth? / Aaron Coleman -- Vita Eruhimovitz -- Carling Hale -- Amanda Helman -- Mike Helms / Ming Ying Hong -- Ming Ying Hong / Emily J. Hanson -- Sea A Joung / Ervin Malakaj -- Stephanie Kang / Jeremy Shipley -- Dayna Jean Kriz / Andrew Johnson -- Thomas Moore : you should move to the city / Nathaniel Rosenthalis -- Jacob Muldowney -- Laurel Panella / Garrett Clough -- Caitlin Penny -- On the bridge, between Juarez and El Paso / Eric Lyle Schultz -- Jeremy Shipley -- Emmeline Solomon -- Kellie Spano / Margaux Crump -- Michael Aaron Williams -- Austin R. Wolf : monumental labor / Adam Turl.https://openscholarship.wustl.edu/books/1015/thumbnail.jp

MFA09 (MFA 2009)

Catalogue of a culminating student exhibition held at the Mildred Lane Kemper Art Museum in 2009. Content includes A new paradigm / Carmon Colangelo -- Evolving practices / Patricia Olynyk -- Stephanie Barenz -- Carolyn Dawn Bendel -- Jacob Cruzen -- Rachel Ann Dennis -- Bryan Eaton -- Maya Escobar -- Meredith Foster -- Morgan Gehris -- Gina Grafos -- Stephen Hoskins -- Amelia Jones -- Hye Young Kim -- Anne Lindberg -- Goran Maric -- Kelda Martensen -- Erica L. Millspaugh -- Carianne Noga -- Joel Parker -- Rebecca C. Potts -- Shannon Randol -- Elaine Rickles -- Michael Kenneth Smith -- Dan Solberg -- Natalie Toney -- Glenn Tramantano -- Kathryn Trout -- J. Taylor Wallace.https://openscholarship.wustl.edu/books/1006/thumbnail.jp

Serum marker of inflammasome activity correlates with liver injury in nonalcoholic fatty liver disease and is influenced by genetic polymorphisms

Background and Aims: The NLRP3 inflammasome has been implicated in the pathogenesis of liver injury in nonalcoholic fatty liver disease (NAFLD). In humans, mutations of Nlrp3 have functional consequences and result in auto-inflammatory syndromes. We examined whether single nucleotide polymorphisms (SNP’s) of the NLRP3 and CARD8 genes of the NLRP3 inflammasome influenced serum inflammatory markers and fatty liver in a general population based cohort. Secondly, we examined serum caspase-1 as a novel marker of liver injury and determined the association between inflammasome SNP’s, serum caspase-1 and liver injury. Methods: Inflammatory markers (CRP, IP-10, TNFR1, TNFR2, IL18), liver enzymes and ultrasound diagnosed fatty liver were assessed in a popula - tion-based cohort (n=1046) of 17-year old adolescents. Serum caspase-1 activity and protein levels were determined in a second cohort (n=154) and sub-group (n=20) of subjects with biopsy proven NAFLD by flourometric assay (Abcam, Cam - bridge, MA) and western blot respectively. Liver histology was evaluated according to the NASH CRN scoring system. Eleven NLRP3 and CARD8 SNPs were genotyped in both cohorts and assessed for phenotypic associations. Results: In cohort 1, the rs2043211 SNP in the CARD8 gene was associated with serum levels of IP10 (p=0.002), IL18 (p=0.009), sTNFR1 (p=0.04), sTNFR2 (p=0.04), CRP (p=0.056) and a diagnosis of fatty liver (adj. odds ratio 1.65, 95% CI 1.09-2.48, dominant allelic model). Serum IP10 and TNFR2 levels but not SNP genotypes were positively correlated with hepatic aminotransaminase levels. In cohort 2, serum caspase-1 activity was significantly increased in the presence of hepatocellular ballooning, inflammation and fibrosis (p<0.05 for all). The accuracy at predicting inflammation, ballooning or advanced fibrosis was modest with area under the receiver operator characteristic curves of 0.62 (95% CI 0.52-0.71), 0.58 (95% CI 0.49-0.67) and 0.66 (0.55-0.76) respectively. Serum caspase-1 p10 protein levels were also significantly higher in subjects with NASH compared to controls or simple steatosis (p=0.003). Rs2043211 was not associated with altered serum caspase-1 levels (p=0.14) or severity of liver injury or fibrosis. Rs10754558 was associated with reduced serum caspase-1 activity (p=0.03) but not alterations in liver injury or fibrosis. Conclusions: Genetic poly - morphisms in the NLRP3 inflammasome associate with altered serum inflammatory markers and risk of fatty liver in the general population, but they do not influence severity of liver injury in NAFLD. Serum caspase-1 activity may represent a novel non-invasive marker of disease severity in NAFLD