Impact of the lipid-based nutrient supplements on prevention and treatment of childhood moderate undernutrition

Purpose: This review aims at assessing the effectiveness of LNS interventions for prevention and/or treatment of moderate acute malnutrition (MAM), stunting and other anthropometric indicators for undernutrition in children younger than 5 years. Methodology: Eighteen clinical trials on LNS (soybased or milk-based) supplementation in children were compared with habitual diet/control or corn-soy blend (CSB). Mean changes in height for age (HAZ), weight for age (WAZ) and weight for height z-scores (WHZ) were assessed as primary outcomes. The secondary outcomes included: weight gain, height, mid upper arm circumference (MUAC), recovery from MAM, occurrence of fever, diarrhoea and cough. Findings: The pooled estimate revealed a statistically significant increase in WAZ (weighted mean difference [WMD] =0.09; 95%CI= 0.02, 0.15; p=0.01), WHZ (WMD=0.14; 95%CI= 0.01, 0.26; p=0.000) and improved recovery from MAM (Risk Ratio [RR] = 1.37; 95%CI= 1.14, 1.65; p=0.000) in children receiving LNS compared with control or CBS. No significant effect was observed in HAZ (WMD=0.00;95%CI=-0.02,0.03: p=0.578). Children fed with milk-based LNS (RR=1.68; 95%CI=1.17, 2.39; p=0.005) were more likely to recover significantly from MAM when compared with CSB. Conclusion: Although there is evidence that LNS yield better nutritional outcomes than CSB and control, it is impossible to conclude that the milk-based LNS are superior to soy-based LNS and whether age and duration of intervention significantly affect the effectiveness of LNS on childhood undernutrition. Further research is required before these products can be recommended at scale

Direct Stimulation of Adult Neural Stem/Progenitor Cells In Vitro and Neurogenesis In Vivo by Salvianolic Acid B

Background: Small molecules have been shown to modulate the neurogenesis processes. In search for new therapeutic drugs, the herbs used in traditional medicines for neurogenesis are promising candidates. Methodology and Principal Findings: We selected a total of 45 natural compounds from Traditional Chinese herbal medicines which are extensively used in China to treat stroke clinically, and tested their proliferation-inducing activities on neural stem/progenitor cells (NSPCs). The screening results showed that salvianolic acid B (Sal B) displayed marked effects on the induction of proliferation of NSPCs. We further demonstrated that Sal B promoted NSPCs proliferation in dose- and time-dependent manners. To explore the molecular mechanism, PI3K/Akt, MEK/ERK and Notch signaling pathways were investigated. Cell proliferation assay demonstrated that Ly294002 (PI3K/Akt inhibitor), but neither U0126 (ERK inhibitor) nor DAPT (Notch inhibitor) inhibited the Sal B-induced proliferation of cells. Western Blotting results showed that stimulation of NSPCs with Sal B enhanced the phosphorylation of Akt, and Ly294002 abolished this effect, confirming the role of Akt in Sal B mediated proliferation of NSPCs. Rats exposed to transient cerebral ischemia were treated for 4 weeks with Sal B from the 7th day after stroke. BrdU incorporation assay results showed that exposure Sal B could maintain the proliferation of NSPCs after cerebral ischemia. Morris water maze test showed that delayed post-ischemic treatment with Sal B improved cognitive impairment after stroke in rats

Impact of the lipid-based nutrient supplements on prevention and treatment of childhood moderate undernutrition

Purpose: This review aims at assessing the effectiveness of LNS interventions for prevention and/or treatment of moderate acute malnutrition (MAM), stunting and other anthropometric indicators for undernutrition in children younger than 5 years. Methodology: Eighteen clinical trials on LNS (soybased or milk-based) supplementation in children were compared with habitual diet/control or corn-soy blend (CSB). Mean changes in height for age (HAZ), weight for age (WAZ) and weight for height z-scores (WHZ) were assessed as primary outcomes. The secondary outcomes included: weight gain, height, mid upper arm circumference (MUAC), recovery from MAM, occurrence of fever, diarrhoea and cough. Findings: The pooled estimate revealed a statistically significant increase in WAZ (weighted mean difference [WMD] =0.09; 95%CI= 0.02, 0.15; p=0.01), WHZ (WMD=0.14; 95%CI= 0.01, 0.26; p=0.000) and improved recovery from MAM (Risk Ratio [RR] = 1.37; 95%CI= 1.14, 1.65; p=0.000) in children receiving LNS compared with control or CBS. No significant effect was observed in HAZ (WMD=0.00;95%CI=-0.02,0.03: p=0.578). Children fed with milk-based LNS (RR=1.68; 95%CI=1.17, 2.39; p=0.005) were more likely to recover significantly from MAM when compared with CSB. Conclusion: Although there is evidence that LNS yield better nutritional outcomes than CSB and control, it is impossible to conclude that the milk-based LNS are superior to soy-based LNS and whether age and duration of intervention significantly affect the effectiveness of LNS on childhood undernutrition. Further research is required before these products can be recommended at scale

The Role of Anions in Metal Chalcogenide Oxygen Evolution Catalysis: Electrodeposited Thin Films of Nickel Sulfide as “Pre-catalysts”

Oxygen evolution catalysts composed of a metal (Ni, Co, or Fe) and a pnictide or chalcogenide (P, S, or Se) counterion are a promising class of electrocatalysts for the oxygen evolution reaction (OER), an important reaction for the photoelectrochemical splitting of water. We synthesized a nickel-based oxygen evolution catalyst derived from pulse-electrodeposited nickel sulfide. This catalyst was found to produce current densities of 10 mA/cm² at the relatively low overpotential of 320 mV in alkaline electrolyte (1 M KOH). Importantly, we found that the sulfur anion in the nickel sulfide is depleted in the active form of the electrocatalyst and that the NiS is converted into an amorphous nickel oxide in the potential range where water is oxidized to oxygen. The superior catalytic activity of this nickel sulfide is thus unrelated to the sulfur anions in the active catalyst but is instead related to the metal sulfide’s ability to act as a precursor to a highly active nickel oxide OER electrocatalyst. The nickel oxide derived from nickel sulfide was found to be amorphous with a relatively high surface area, two factors that have been previously shown to be important in oxygen evolution electrocatalysis

Structural and Catalytic Effects of Iron- and Scandium-Doping on a Strontium Cobalt Oxide Electrocatalyst for Water Oxidation

The poor kinetics of the oxygen evolution reaction (OER) are a considerable barrier to the development of water-derived hydrogen fuel. Previous work regarding theoretical calculations of the perovskite SrCoO_3‑δ (SCO) predicts a surface binding energy ideal for OER catalysis but could not be matched to experimental results due to the material’s propensity to form the incorrect trigonal crystal structure. By doping with iron and scandium, X-ray diffraction confirms that we have been able to synthesize a series of SCO catalysts of various crystal structures, culminating in cubic SCO. In doing so, we show that there is a limited correlation between the crystal structure and OER performance in alkaline media. Instead, the use of iron as a dopant is found to decrease the OER overpotential of the SCO by 40 mV in 0.1 M KOH and yield catalysts capable of performing water oxidation at an overpotential of 410 mV at 10 mA/cm². The doped, cubic SCO catalysts are found to be more stable than the undoped material when tested for extended periods, showing only an approximate 3 mV increase in overpotential over a 2 h period at 10 mA/cm². Our results show that proper doping of the B-site cation in SCO allows for tuning the structure, performance, and stability of the oxide as an OER electrocatalyst

Harvest of violence: the neglect of basic rights and the Boko Haram insurgency in Nigeria.

Drawing on the core commitments of Critical Terrorism Studies, and mostly, the ethic of emancipation, this article focuses on the Boko Haram insurgency to investigate recurring violent conflict in Nigeria. It identifies a governance gap not adverted to in the official narrative which has led to gross discontent at the lower levels of the society. The governance gap has created fertile breeding grounds for the recruitment of disillusioned youths who are easily mobilised to violence and lately, insurgency. There are normative and pragmatic reasons to adopt and prioritise social welfare through the implementation of economic, social and cultural obligations and due-process rights as a viable approach to at least reducing the spate of violence in the country. The discussion has relevance for resolving situations of violence and conflict in sub-Sahara Africa in particular and elsewhere in the developing world