Dutch juvenile idiopathic arthritis patients, carers and clinicians create a research agenda together following the James Lind Alliance method: A study protocol

Background: Research on Juvenile Idiopathic Arthritis (JIA) should support patients, caregivers/parents (carers) and clinicians to make important decisions in the consulting room and eventually to improve the lives of patients with JIA. Thus far these end-users of JIA-research have rarely been involved in the prioritisation of future research. Main body: Dutch organisations of patients, carers and clinicians will collaboratively develop a research agenda for JIA, following the James Lind Alliance (JLA) methodology. In a 'Priority Setting Partnership' (PSP), they will gradually establish a top 10 list of the most important unanswered research questions for JIA. In this process the input from clinicians, patients and their carers will be equally valued. Additionally, focus groups will be organised to involve young people with JIA. The involvement of all contributors will be monitored and evaluated. In this manner, the project will contribute to the growing body of literature on how to involve young people in agenda setting in a meaningful way. Conclusion: A JIA research agenda established through the JLA method and thus co-created by patients, carers and clinicians will inform researchers and research funders about the most important research questions for JIA. This will lead to research that really matters

De gloeidraad anemometer

Stromingsleer is de naam van het vakgebied dat ‘stromende media’ beschrijft. Dat medium kan lucht of water zijn, maar ook olie, mayonaise, of lucht-watermengsels. Als we het vakgebied wat ruimer nemen dan stromen zand- of suikerkorrels ook. Kortom, alles stroomt, of zoals Heraclitus het rond 500 vóór Christus verwoordde: ‘Panta Rhei’. En dat is de naam van het dispuut voor studenten van het Laboratorium voor Aëro- en Hydrodynamica van de TU Delft, naar waar ik u wil meenemen.In 1918 werd het Laboratorium opgericht als onderdeel van de toenmalige Afdeling Werktuigbouwkunde en Scheepsbouwkunde van de Technische Hoogeschool te Delft. Het lab kwam onder leiding van Johannes Martinus (Jan) Burgers, de eerste Nederlandse hoogleraar specifiek op het vakgebied Stromingsleer. Burgers en zijn verdienste voor wetenschap en maatschappij zijn uitgebreid beschreven in [2,4,5]. Burgers was onder meer mede-grondlegger van de International Union for Theoretical and Applied Mechanics (IUTAM) en is sinds 1991 naamgever aan de nationale Onderzoeksschool voor Stromingsleer, het JM Burgerscentru

Oral ileocolonic drug delivery by the colopulse-system:A bioavailability study in healthy volunteers

The release profile of a novel oral ileocolonic drug delivery technology (ColoPulse-technology) was assessed by a combination of conventional kinetics of a marker substance in blood and site-specific signaling by stable isotope technology. Since ileocolonic delivery involves the drug release in a region in which bacteria are highly present, a prolonged lag time should coincide with proven bacterial enzyme activity. The latter can be tested using (13)C-urea as the marker substance. The study was designed as a two period (uncoated versus coated capsule) crossover single dose bioavailability study in healthy subjects. The (13)C-recovery data after oral administration of (13)C-urea using the ColoPulse delivery system showed a delayed sigmoid release in all subjects with a lag time of >3 h (median: 330 min.). Release was achieved in a urease-containing intestinal segment in all healthy subjects. Complete release in the ileocolonic region was achieved in 10 of 11 subjects. The ColoPulse-technology therefore enables specific and reliable drug delivery in the ileocolonic region in healthy volunteers. (c) 2010 Elsevier B.V. All rights reserved