1 research outputs found
Population genomics diversity of Plasmodium falciparum in malaria patients attending Okelele Health Centre, Okelele, Ilorin, Kwara State, Nigeria.
Background: Plasmodium falciparum, the most dangerous malaria parasite
species to humans remains an important public health concern in
Okelele, a rural community in Ilorin, Kwara State, Nigeria. There is
however little information about the genetic diversity of Plasmodium
falciparum in Nigeria. Objective: To determine the population genomic
diversity of Plasmodium falciparum in malaria patients attending
Okelele Community Healthcare Centre, Okelele, Ilorin, Kwara State.
Methods: In this study, 50 Plasmodium falciparum strains Merozoite
Surface Protein 1, Merozoite Surface Protein 2 and Glutamate Rich
Protein were analysed from Okelele Health Centre, Okelele, Ilorin,
Nigeria. Genetic diversity of P. falciparum isolates were analysed from
nested polymerase chain reactions (PCR) of the MSP-1 (K1, MAD 20 and
RO33), MSP-2 (FC27 and 3D7) and Glutamate Rich Protein allelic families
respectively. Results: Polyclonal infections were more in majority of
the patients for MSP-1 allelic families while monoclonal infections
were more for MSP-2 allelic families. Multiplicity of infection for
MSP-1, MSP-2 and GLURP were 1.7, 1.8 and 2.05 respectively Conclusion:
There is high genetic diversity in MSP \u2013 2 and GLURP allelic
families of Plasmodium falciparum isolates from Okelele Health Centre,
Ilorin, Nigeria