Kaplan-Meier plot of the cumulative probability of remaining event free for patients with UMI versus patients without UMI.

<p>P<0.001. Blue line = No UMI. Green line = UMI.</p

Multivariable logistic regression analyses of the primary endpoint.

<p>Multivariable logistic regression analyses of the primary endpoint.</p

Univariate predictors of prognosis.

<p>Univariate predictors of prognosis.</p

Study outline.

<p>Study outline.</p

Examples of representative CMR-LGE images in patients with and without UMIs.

<p><b>a</b>. subendocardial UMI, <b>b</b>. transmural UMI, <b>c.</b> area of LGE without a subendocardial component, i-e. no MI, <b>d.</b> no LGE, i.e. normal myocardium.</p

Clinical characteristics.

<p>Clinical characteristics.</p

Additional file 4: of Unrecognized myocardial infarctions assessed by cardiovascular magnetic resonance are associated with the severity of the stenosis in the supplying coronary artery

Coronary angiography of right coronary artery. (MOV 17215 kb

Additional file 5: of Unrecognized myocardial infarctions assessed by cardiovascular magnetic resonance are associated with the severity of the stenosis in the supplying coronary artery

Figure S1. All UMIs plotted according to size in grams (g). (PPTX 99 kb

Radiation dose distribution in coronary arteries in breast cancer radiotherapy

<p><b>Background:</b> Women irradiated for left-sided breast cancer (BC) have an increased risk of coronary artery disease compared to women with right-sided BC. We describe the distribution of radiation dose in segments of coronary arteries in women receiving adjuvant radiotherapy (RT) for left- or right-sided BC.</p> <p><b>Material and methods:</b> Fifteen women with BC, seven left-sided and eight right-sided, who had received three-dimensional conformal radiotherapy (3DCRT), constituted the study base. The heart and the segments of the coronary arteries were defined as separate organs at risk (OAR), and the mean and maximum radiation doses were calculated for each OAR.</p> <p><b>Results:</b> In women with left-sided BC, irrespective of if regional lymph node RT was given or not, maximum dose in mid and distal left anterior descending artery (mdLAD) was approximately 50 Gy in 6/7 patients, whereas women with right-sided BC mainly received low doses of radiation. In women with left-sided BC, 6/7 patients had substantially higher mean dose to the distal LAD than to the heart, ranging from 30 to 55 Gy and 3 to13 Gy, respectively.</p> <p><b>Conclusion:</b> We found a pronounced difference of radiation dose distribution in the coronary arteries between women with left- and right-sided BC. Women with left-sided BC had almost full treatment dose in parts of mdLAD, regardless of if regional lymph node irradiation was given or not, while women with right-sided BC mainly received low doses to the coronary arteries.</p

Multivariable logistic regression analyses of the primary endpoint as outcome variable.

<p>Model 1: unrecognized myocardial infarction (UMI), age and gender. Model 2: UMI, age and ≥70% stenosis. Model 3: UMI, age and the extent of coronary artery disease (CAD). Model 4: age, UMI in an area supplied by a coronary artery with a ≥70% stenosis (UMI with match) and UMI in an area supplied by a coronary artery without a ≥70% stenosis (UMI without match). Presented as OR and 95% CI.</p