The Effect of Omeprazole Administration to the Quality of Life of Gastro Esophageal Reflux Disease Patients

Background: The quality of life of Gastro Esophageal Reflux Disease (GERD) patients will consistently decline both physically and psychologically compared to the general population. WHOQOL-BREF is a questionnaire to evaluate the quality of life with high validity and reliability. One of GERD therapy is a proton pump inhibitor (PPI). There are studies on PPI administration in GERD patients worldwide, however in Indonesia there is limited research evaluating how PPI especially Omeprazole influences the quality of life in GERD. We determined the effect of omeprazole to the quality of life of patients with GERD. Methods: GERD questionnaires (GERDQ) was used to determine life quality of GERD patients and interpretation was performed based on score obtained. The comparison between the perception of the quality of life and perception of health satisfaction in GERD patients before and after Omeprazole administration was analyzed using Wilcoxon signed rank test. While, the comparison of the quality of life based on WHOQOL-BREF before and after administration of omeprazole was analyzed using Wilcoxon signed rank test and t-test. Results: We included 43 GERD patients with the mean age of 39.50±5.71 years. The most complaints were nausea, pain in the upper middle part of the stomach and heartburn (88.4%; 81.4% and 79.1%, respectively). There was a significant difference in the perception of quality of life (p=0.000) and the perception of health satisfaction (p=0.001) but, there was no significant difference in WHOQOL- BREF scores before and after Omeprazole administration (each domains of physical, social, psychological, environmental was p=0.275; p=0.380; p=0.199; p=0.810 respectively). Conclusion: Omeprazole did not improve the quality of life of GERD patients

PENGARUH PEMBERIAN OMEPRAZOLE TERHADAP KUALITAS HIDUP PASIEN GASTRO ESOPHAGEAL REFLUX DISEASE Penelitian Experimental one sample pretest - post test design Di Instalasi Rawat Jalan Gastroentero-Hepatologi Departemen/SMF Penyakit Dalam RSUD Dr. Soetomo Surabaya

Latar belakang: Kualitas hidup pasien GERD secara konsisten akan menurun baik secara fisik maupun psikologis jika dibandingkan populasi umum. WHOQOL-BREF adalah kuisioner untuk mengevaluasi kualitas hidup dengan validitas dan kehandalan yang tinggi. Salah satu terapi GERD adalah dengan pemberian proton pump inhibitor (PPI). Penelitian tentang pemberian PPI pada pasien GERD telah banyak dilakukan di luar negeri, namun sampai saat ini di Indonesia belum ada penelitian yang mengevaluasi pengaruh pemberian PPI khususnya Omeprazole terhadap kualitas hidup pasien GERD. Tujuan: Mengetahui pengaruh Omeprazole terhadap kualitas hidup pasien GERD Metode: Penelitian ini merupakan penelitian Experimental dengan one sample pretest - post test design, pada 43 pasien GERD dewasa dengan skor GERD Quesioner (GERDQ)>8, skor SRRS<150 (tidak sedang mengalami gangguan jiwa serta tidak mendapat intervensi psikofarmaka maupun psikoterapi). Uji komparasi persepsi kualitas hidup dan persepsi kepuasan kesehatan pasien GERD sebelum dan sesudah pemberian Omeprazole dengan uji wilcoxon sign rank test. Perbandingan kualitas hidup berdasar pada WHOQOL-BREF sebelum dan sesudah pemberian Omeprazole dengan uji wilcoxon sign rank test dan t test. Hasil: Responden perempuan dua kali lebih banyak daripada laki-laki dan rerata usia 39,50±5,71 tahun. Rerata IMT adalah 21,85±4,03 kg/m2, keluhan terbanyak berupa mual, nyeri pada bagian tengah perut atas dan heartburn (88,4%; 81,4% dan 79,1%). Terdapat perubahan signifikan pada persepsi kualitas hidup dan persepsi kepuasan kesehatan (p= 0,000) dan (p=0,001) namun tidak ditemukan perbedaan signifikan pada skor WHOQOL-BREF sebelum dan sesudah pemberian Omeprazole (domain fisik, sosial, psikis, lingkungan masing-masing p= 0,275; p= 0,380; p= 0,199; p=0,810