72 research outputs found
Erratum to: Assignment of EPR transitions in a manganese-containing lipoxygenase and prediction of local structure
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Linoleic Acid 8R-Dioxygenase and Hydroperoxide Isomerase of the Fungus Gaeumannomyces graminis.
No full textCarteriosulfonic acids A−C, GSK-3β inhibitors from aCarteriospongiasp.
No full textModulators of Wnt signaling have therapeutic potential in a number of human diseases. A fractionated library from marine invertebrates was screened in a luciferase assay designed to identify modulators of Wnt signaling. A fraction from a Carteriospongia sp. sponge activated Wnt signaling and was subsequently shown to inhibit GSK-3beta, which inhibits Wnt signaling through phosphorylation of beta-catenin. Three novel natural products, carteriosulfonic acids A (1), B (2), and C (3), were identified as active constituents. The carteriosulfonic acids contain unprecedented 4,6,7,9-tetrahydroxylated decanoic acid subunits. Their structures were elucidated through analysis of NMR data and a detailed analysis of pseudo MS(3) spectra
A New Series of Natural Prostaglandins Identification of 1a,1b-dihomo-2,3-didehydro-PGE 2
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Linolenate 9R-Dioxygenase and Allene Oxide Synthase Activities of Lasiodiplodia theobromae
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The secretory activity of the seminal vesicles and its relationship to sperm motility: effects of infection in the male reproductive tract
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