5 research outputs found
Line plots of mean concentrations across subjects of nicotine in plasma versus time of active and placebo cigarette scans.
<p>PET data acquisition began between 5 and 10 min on the time axis in individual subjects.</p
Concentrations of nicotine and metabolites in plasma during active and placebo cigarette scans.
<p>Mean ± standard deviation (ng/mL) of individual subjects' means across 2–75 min, except for the second nicotine row representing nicotine concentrations only from 2–10 min.</p><p>Limits of quantification were 1 ng/mL for cotinine, OH-cotinine and norcotinine, and 2.5 ng/mL for nicotine at individual time point.</p><p>* Active cigarette scan values > placebo cigarette scan value at p<0.01; paired t-test.</p>#<p>Smoker > nonsmoker at p<0.00001; t-test.</p><p>Concentrations of nicotine and metabolites in plasma during active and placebo cigarette scans.</p
Clusters of Δ[<sup>11</sup>C]carfentanil BP<sub>ND</sub> (placebo - active) to ΔVAS (active - placebo) correlation.
<p>Significance criteria: p<0.001, uncorrected and volume >0.4 mL.</p><p>Percentages in the last column indicate anatomical constituents of clusters.</p><p>Clusters of Δ[<sup>11</sup>C]carfentanil BP<sub>ND</sub> (placebo - active) to ΔVAS (active - placebo) correlation.</p
Positive correlation clusters of Δ[<sup>11</sup>C]carfentanil binding potential (BP<sub>ND</sub>) (placebo - active) versus ΔVAS of feel the effect category in smokers, displayed on trans-axial images of a gray-matter probability maps.
<p>Scatter plots of cluster Δ[<sup>11</sup>C]carfentanil BP<sub>ND</sub> values to ΔVAS are shown together with regression lines. VAS stands for the visual analog scale of smoking effects, and <i>R<sup>2</sup></i> stands for the coefficient of determination of linear regression.</p
Correlation clusters of [<sup>11</sup>C]carfentanil binding potential (BP<sub>ND</sub>) of placebo-cigarette scans versus the Fagerström Test for Nicotine Dependence (FTND) in smokers, displayed on trans-axial images of a gray-matter probability maps.
<p>Right panels show scatter plots using cluster [<sup>11</sup>C]carfentanil BP<sub>ND</sub>, together with regression line. In regression equations, <i>R<sup>2</sup></i> stands for the coefficient of determination.</p