General characteristic of the participants prior to training.

<p>The values presented are the mean ± standard error of mean for 32 normal weight (NWG), 59 overweight (OVG) and 52 obese (OBG) individuals.</p><p>^a comparison to NWG</p><p>^b comparison to OVG.</p><p>General characteristic of the participants prior to training.</p

Effect of exercise on cardiometabolic parameters in normal weight (NWG), overweight (OVG) and obese (OBG) groups.

<p>The values presented are the mean ± standard error of mean for 27 normal weight, 57 overweight and 52 obese individuals.</p><p>^a comparison to NWG</p><p>^b comparison to OVG</p><p>^c comparison to before program training (T0)</p><p>^d comparison to after 6 months program training (T6).</p><p>Effect of exercise on cardiometabolic parameters in normal weight (NWG), overweight (OVG) and obese (OBG) groups.</p

Effect of exercise on anthropometric parameters of normal weight (NWG), overweight (OVG) and obese (OBG) groups.

<p>The values presented are the mean ± standard error of mean for 32 normal weight, 59 overweight and 52 obese.</p><p>^a comparison to NWG</p><p>^b comparison to OVG.</p><p>Effect of exercise on anthropometric parameters of normal weight (NWG), overweight (OVG) and obese (OBG) groups.</p

Effect of exercise on adipokines in normal weight (NWG), overweight (OVG) and obese (OBG) groups.

<p>Plasma and serum was separated immediately after blood collection before (T0), after 6 months (T6) and 12 months (T12) of the exercise training program. The plasma or serum concentrations of leptin, adiponectin, IL-6 and resistin were determined using an Enzyme-linked immunosorbent assay (ELISA) method. The values presented are the mean ± standard error of mean. ^a comparison to normal weight group; ^b comparison to overweight group; ^c comparison to before program training (T0); ^d comparison to after 6 months of program training.</p

Effect of exercise on fitness capacity in normal weight (NWG), overweight (OVG) and obese (OBG) groups.

<p>Aerobic capacity and isometric back strength were evaluated before (T0), after 6 months (T6) and 12 months (T12) of the exercise training program. The values presented are the mean ± standard error of mean. ^c comparison to before training.</p

Effect of the marathon race on neutrophil surface molecules and DNA fragmentation.

<p>Neutrophils were separated after blood collection before, immediately after, 24 h after, and 72 h after the marathon race. Expression of ICAM-1 (A), TNFR1 receptor (B), L-selectin (C), and Fas receptor (D), and % of cells with DNA fragmentation (D) were determined. The fluorescence was determined by flow cytometry (BD Accuri cytometer). The values presented are the mean ± SEM of 21 runners. ^a p<0.05 vs before the marathon race, ^b p<0.05 vs immediately after the marathon race, and ^cp<0.05 vs 24 h after the marathon race.</p

Model on the temporal dynamics of the cytokine’s responses to the marathon race.

<p>Model on the temporal dynamics of the cytokine’s responses to the marathon race.</p

Effect of the marathon race on muscle damage markers and CRP.

<p>The plasma was separated before, immediately after, 24 h after, and 72 h after the marathon race. The plasma activities of LDH (A), CK (C), CK-MB (D), and plasma levels of CRP (B) were determined. The values presented are the mean ± SEM of 23 runners.^a p<0.001 vs before the marathon race, ^b p<0.0001 vs immediately after the marathon race, and ^c p<0.01 vs 24 h after the marathon race.</p

Effect of the marathon race on hematological parameters.

<p>Total leukocyte number (A), neutrophil number (B), hematocrit (C), and hemoglobin (D) were determined before, immediately after, 24 h, and 72 h after the marathon race. The values presented are the mean ± SEM of 23 runners.^ap<0.05 vs before the marathon race, ^bp<0.05 vs immediately after the marathon race, and ^cp<0.05 vs 24 h after the marathon race.</p

Effect of the marathon race on plasma cytokines.

<p>Plasma concentrations of IL-6 (A), IL-8 (B) IL-10 (C), IL-12 (D), and TNF-alpha (E) were determined using cytometric bead array. The values presented are the mean ± SEM of 23 runners.^ap<0.05 vs before the marathon race, ^bp<0.05vs immediately after the marathon race, and ^c p<0.05 vs 24 h after the marathon race.</p