A species distribution comparison of <i>Staphylococcus</i> spp. isolates from the positive blood cultures of patients in neonatal intensive care units (NICUs) and adult ICUs, 2004–2009.

a<p>The differences between the groups were tested for statistical significance using a two-tailed Fisher's exact test. <i>P</i> values were corrected for multiple testing using the Holm-Bonferroni method.</p

A retrospective comparison of the antimicrobial resistance profiles of methicillin-resistant and methicillin-susceptible <i>Staphylococcus capitis</i> bloodstream isolates from patients in neonatal intensive care units, 2004–2009.

a<p>The differences between the groups were tested for statistical significance using a two-tailed Fisher's exact test. <i>P</i> values were corrected for multiple testing using the Holm-Bonferroni method.</p>b<p>NC, not calculable.</p

Flow diagram of case selection.

<p>(N)ICU, (neonatal) intensive care unit; CoNS, coagulase-negative staphylococci; BC, blood culture. ^aIn NICU infants, a single CoNS-positive blood culture was interpreted as possible bacteremia and included in the analysis. The CoNS-positive results that were excluded were explicitly recorded as a contaminant in the microbiology record. ^bIn adult patients, a single CoNS-positive blood culture was interpreted as a contaminant and excluded from the analysis. ^cRecords were excluded when antimicrobial susceptibility results were not available.</p

A retrospective comparison of the antimicrobial resistance profiles of <i>Staphylococcus capitis</i> bloodstream isolates from patients in neonatal intensive care units (NICUs) and adult ICUs, 2004–2009.

a<p>The differences between the groups were tested for statistical significance using a two-tailed Fisher's exact test. <i>P</i> values were corrected for multiple testing using the Holm-Bonferroni method.</p

<i>Staphylococcus capitis</i> isolates from distant neonatal intensive care units (NICUs) are clonal.

<p>Pulsed-field gel electrophoresis (PFGE) was applied to 53 bloodstream isolates of <i>S. capitis</i> that were collected from NICU infants and adult patients from cities spanning the French territory. The PFGE dendrogram was generated using the GelCompar software version 4.1. The isolates were assigned to pulsotypes using >80% similarity (vertical dashed line). Staphylococcal chromosomal cassette <i>mec</i> (SCC<i>mec</i>) typing was applied to 23 methicillin-resistant isolates representative of each pulsotype and geographic origin. All methicillin-resistant isolates from the different NICUs belonged to the same pulsotype and shared a type V-related SCC<i>mec</i> element, whereas methicillin-susceptible and/or non-NICU isolates were genetically diverse. <i>ccr</i>, chromosomal cassette recombinase; unkn., unknown (a combination of the <i>mec</i> complex and <i>ccr</i> genes has not been assigned to an SCC<i>mec</i> type so far).</p