Hemodynamics.

<p>DBP = diastolic blood pressure (BP); HR = heart rate; MAP = mean BP; RPP = rate pressure product; SBP = systolic BP.</p><p>P-values are given for the comparison of baseline vs. caffeine.</p

Coronary resistance during physical exercise.

<p>Coronary resistance at exercise increased in all groups. A massive increase in resistance was found in stenotic segments. ‡<i>P</i><0.05 for the comparison versus remote. *<i>P</i><0.05 for the comparison versus remote segments and age-matched controls.</p

Myocardial perfusion reserve: effects of caffeine.

<p>Caffeine decreases myocardial perfusion reserve. This effect was most pronounced in stenotic segments of CAD patients. *<i>P</i><0.05 for the comparison versus baseline.</p

Exercise-induced hyperemia: effects of caffeine.

<p>Caffeine decreases exercise-induced hyperaemic MBF. This effect was most prominent in stenotic segments of CAD patients. *<i>P</i><0.005 for the comparison versus baseline.</p

Myocardial Blood Flow, Coronary Resistance and Flow Reserve.

<p>MBF, myocardial blood flow (ml/min/g). Cor Res, coronary resistance (mmHg/ml/min/g). MPR, myocardial perfusion reserve (relative values). Ex, exercise.</p>*<p>P<0.05 for the comparison with remote segments.</p>†<p>P<0.05 for the comparison with age-matched controls.</p