Significant changes in AD from pre-RT to one month post-RT.

<p>Arrowheads: Z = +10, right superior longitudinal fasciculus; Z = +35, right superior cingulum; Y = −40, right superior cingulum. Significant results per color chart, blue is TBSS skeleton without significant results. Depicted on MNI ICBM152 standard brain T1-weighted image <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0057768#pone.0057768-Mazziotta1" target="_blank">[34]</a>. Units are µm²/s.</p

Repeated-measures ANOVA of FA changes from pre-RT to end-RT.

<p>Degrees of freedom for within-subject effects corrected for lack of sphericity by Greenhouse-Geisser method, ε = 0.311.</p

Patient characteristics.

<p>Patient characteristics.</p

Fourteen white matter structures.

<p>Fourteen white matter structures.</p

Significant changes in FA from pre-RT to end-RT.

<p>Arrowheads: Z = −5, left inferior cingulum; Z = +25, corpus callosum body; Y = −40, left inferior cingulum; X = 0, fornix columns. Significant results per color chart, blue is TBSS skeleton without significant results. Depicted on Montreal Neurological Institute (MNI) ICBM152 standard brain T1-weighted image <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0057768#pone.0057768-Mazziotta1" target="_blank">[34]</a>.</p

Significant changes in RD from pre-RT to end-RT.

<p>Arrowheads: Z = −5, left inferior cingulum; Z = +10, left fornix crus; Z = +25, corpus callosum body; Y = −40, left inferior cingulum; X = 0, fornix columns. Significant results per color chart, blue is TBSS skeleton without significant results. Depicted on MNI ICBM152 standard brain T1-weighted image <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0057768#pone.0057768-Mazziotta1" target="_blank">[34]</a>. Units are µm²/s.</p

Pre-RT to one month post-RT significant voxel overlap.

<p>(a) Color key to significant voxel changes from pre-RT to one month post-RT in AD, RD, and FA with overlapping voxels. Underlying white matter skeleton with no significant changes is gray. (b) Venn diagram depicting proportion of white matter skeleton with significant changes. FA = 82.9%; RD = 37.4%; AD = 12.9%; FA ∩ RD = 33.5%; FA ∩ AD = 10.4%; RD ∩ AD = 0.1%. Labels are MNI coordinates.</p

White matter regions of interest.

<p>ICBM DTI-81 white matter atlas <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0057768#pone.0057768-Mori1" target="_blank">[33]</a> depicted on FMRIB58 standard-space FA map <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0057768#pone.0057768-Smith2" target="_blank">[35]</a>. Data-derived white matter skeleton mask in white. AnCr, anterior corona radiata; AnIC, anterior internal capsules; PoIC, posterior internal capsules; ReIC, retrolenticular internal capsules; EC, external capsules; FxCr, fornix crura; InCg, inferior cingula; SuCg, superior cingula; SLF, superior longitudinal fasciculi; FxCo, fornix columns; CCs, corpus callosum splenium; CCb, corpus callosum body; CCg, corpus callosum genu. Posterior corona radiata not depicted.</p

Fractional anisotropy (FA) longitudinal changes by structure.

<p>Statistically significant changes after correction for false discovery rate bolded; non-significant italicized.</p

Axial diffusivity (AD) longitudinal changes by structure.

<p>Statistically significant changes after correction for false discovery rate bolded; non-significant italicized.</p><p>Units are µm²/s.</p