42 research outputs found
Earth Virtualization Engines -- A Technical Perspective
Participants of the Berlin Summit on Earth Virtualization Engines (EVEs)
discussed ideas and concepts to improve our ability to cope with climate
change. EVEs aim to provide interactive and accessible climate simulations and
data for a wide range of users. They combine high-resolution physics-based
models with machine learning techniques to improve the fidelity, efficiency,
and interpretability of climate projections. At their core, EVEs offer a
federated data layer that enables simple and fast access to exabyte-sized
climate data through simple interfaces. In this article, we summarize the
technical challenges and opportunities for developing EVEs, and argue that they
are essential for addressing the consequences of climate change
Earth Virtualization Engines (EVE)
To manage Earth in the Anthropocene, new tools, new institutions, and new forms of international cooperation will be required. Earth Virtualization Engines is proposed as an international federation of centers of excellence to empower all people to respond to the immense and urgent challenges posed by climate change
Recommended from our members
Earth Virtualization Engines: a technical perspective
Participants of the Berlin Summit on Earth Virtualization Engines (EVEs) discussed ideas and concepts to improve our ability to cope with climate change. EVEs aim to provide interactive and accessible climate simulations and data for a wide range of users. They combine high-resolution physics-based models with machine learning techniques to improve the fidelity, efficiency, and interpretability of climate projections. At their core, EVEs offer a federated data layer that enables simple and fast access to exabyte-sized climate data through simple interfaces. In this article, we summarize the technical challenges and opportunities for developing EVEs, and argue that they are essential for addressing the consequences of climate change
Pharmacokinetics of meropenem in septic patients on sustained low-efficiency dialysis: a population pharmacokinetic study
Recommended from our members
Earth Virtualization Engines (EVE)
To manage Earth in the Anthropocene, new tools, new institutions, and new forms of international cooperation will be required. Earth Virtualization Engines is proposed as an international federation of centers of excellence to empower all people to respond to the immense and urgent challenges posed by climate change
TTFIELDS IN ROUTINE CLINICAL CARE OF NEWLY DIAGNOSED GBM PATIENTS IN GERMANY - FIRST REPORT ON THE FULLY ENROLLED TIGER STUDY POPULATION
Pharmacokinetics of meropenem in septic patients on sustained low-efficiency dialysis: a population pharmacokinetic study
The aim of the study was to describe the population pharmacokinetics (PK) of meropenem in critically ill patients receiving sustained low-efficiency dialysis (SLED).Prospective population PK study on 19 septic patients treated with meropenem and receiving SLED for acute kidney injury. Serial blood samples for determination of meropenem concentrations were taken before, during and after SLED in up to three sessions per patient. Nonparametric population PK analysis with Monte Carlo simulations were used. Pharmacodynamic (PD) targets of 40% and 100% time above the minimal inhibitory concentration (f T > MIC) were used for probability of target attainment (PTA) and fractional target attainment (FTA) against Pseudomonas aeruginosa.A two-compartment linear population PK model was most appropriate with residual diuresis supported as significant covariate affecting meropenem clearance. In patients without residual diuresis the PTA for both targets (40% and 100% f T > MIC) and susceptible P. aeruginosa (MIC ≤ 2\ua0mg/L) was > 95% for a dose of 0.5\ua0g 8-hourly. In patients with a residual diuresis of 300\ua0mL/d 1\ua0g 12-hourly and 2\ua0g 8-hourly would be required to achieve a PTA of > 95% and 93% for targets of 40% f T > MIC and 100% f T > MIC, respectively. A dose of 2\ua0g 8-hourly would be able to achieve a FTA of 97% for 100% f T > MIC in patients with residual diuresis.We found a relevant PK variability for meropenem in patients on SLED, which was significantly influenced by the degree of residual diuresis. As a result dosing recommendations for meropenem in patients on SLED to achieve adequate PD targets greatly vary. Therapeutic drug monitoring may help to further optimise individual dosing.Clincialtrials.gov, NCT02287493
Loss of selenoprotein P (SeP) expression in colorectal adenomas: Implications for carcinogenesis
Population pharmacokinetics and dosing simulations of ceftazidime in critically ill patients receiving sustained low-efficiency dialysis
Objectives: To describe the population PKs of ceftazidime in critically ill patients receiving sustained low-efficiency dialysis (SLED)