Morfologia urbana e qualidade do ar: uma proposição metodológica aplicada em caso empíricono Rio de Janeiro

Considerando a importância das cidades como fontes emissoras de poluentes e polos de concentração de população, o trabalho investigapossíveis impactos de aspectos da forma urbana nas concentrações de poluentes. O artigo discute o estado da artesobre as interações entre a qualidade do ar e indicadoresda forma urbana, compara e testa diferentes indicadores da forma urbana, incluindo um indicador de compacidadetridimensional proposto. O artigo sugere uma forma de modelagem e avaliação dessas relações, e apresenta, por fim, um estudo de caso na cidade do Rio de Janeiro, envolvendo métodos estatísticos aplicados a poluentes (SO2, CO e PI), variáveis morfológicas (taxa de ocupação e percentagem de verticalização) e meteorológicas (vento – direção e velocidade -, precipitação pluvial e temperatura do ar). Os resultados apontam para graus de influência das variáveis taxa de ocupação e verticalização na concentração dos poluentes considerados.Considering the importance of cities as pollutants emission sources and population hubs, the work researches possible impacts of the urban form aspects on pollutants concentrations. The paper discussesthe state of art of interactions between air quality and urban form indexes, compares and tests different indicators of urban form, including a proposed tridimensional compacity index. It.s suggested a way of modeling and testing these relations andpresented a case study in Rio de Janeiro city, involving statistical methods applied to pollutants (SO2, CO e PI), morphological variables (ground space index and verticalization) and meteorological (wind . direction and speed - , rainfall and air temperature). Results point to gradesof influenceof the ground space index and verticalizationon concentrations of considered pollutants

Development of a water-in-oil-in-water multiple emulsion system integrating biomimetic aqueous-core lipid nanodroplets for protein entity stabilization. Part I: experimental factorial design

Lipid nanoballoons integrating multiple emulsions of the type water-in-oil-in-water enclose, at least in theory, a biomimetic aqueous-core suitable for housing hydrophilic biomolecules such as proteins, peptides and bacteriophage particles. The research effort entertained in this paper reports a full statistical 23x31 factorial design study (three variables at two levels and one variable at three levels) to optimize biomimetic aqueous-core lipid nanoballoons for housing hydrophilic protein entities. The concentrations of protein, lipophilic and hydrophilic emulsifiers, and homogenization speed were set as the four independent variables, whereas the mean particle hydrodynamic size (HS), zeta potential (ZP) and polydispersity index (PI) were set as the dependent variables. The V23x31 factorial design constructed led to optimization of the higher (+1) and lower (-1) levels, with triplicate testing for the central (0) level, thus producing thirty three experiments and leading to selection of the optimized processing parameters as 0.015% (w/w) protein entity, 0.75% (w/w) lipophilic emulsifier (soybean lecithin) and 0.50% (w/w) hydrophilic emulsifier (poloxamer 188). In the present research effort, statistical optimization and production of protein derivatives encompassing full stabilization of their three-dimensional structure, has been attempted via housing said molecular entities within biomimetic aqueous-core lipid nanoballoons integrating a multiple (W/O/W) emulsion

Characterization of a water-in-oil-in-water multiple emulsion integrating biomimetic aqueous-core lipid nanoballoons housing protein entities

Project funding by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, São Paulo, Brazil) ( FAP ESP Ref. No. 2013/03181 - 6, Project PneumoPhageKill

Supercritical fluid and pharmaceutical applications. Part I: Process classification

The supercritical fluid technology has been target of many pharmaceuticals investigations in particles production for almost 35 years. This is due to the great advantages it offers over others technologies currently used for the same purpose. A brief history is presented, as well the classification of supercritical technology based on the role that the supercritical fluid (carbon dioxide) performs in the process.FAPESP (São Paulo, Brazil – project 2012/01333-0) for financial suppor

Previsão da incidência da leishmaniose visceral usando o modelo de média móvel integrado autorregressivo sazonal (SARIMA) no Maranhão, Brasil

Universidade Federal do Maranhão. Programa de Pós‑graduação Strictu Sensu em Saúde e Ambiente. São Luís, MA, Brasil.Universidade Estadual do Maranhão - Campus Caxias. Programa de Pós‑graduação Strictu Sensu em Biodiversidade, Ambiente e Saúde. Caxias, MA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Universidade Federal do Maranhão. Programa de Pós‑graduação Strictu Sensu em Saúde e Ambiente. São Luís, MA, Brasil.Universidade Estadual do Maranhão - Campus Caxias. Programa de Pós‑graduação Strictu Sensu em Biodiversidade, Ambiente e Saúde. Caxias, MA, Brasil.Universidade Estadual do Maranhão - Campus Caxias. Programa de Pós‑graduação Strictu Sensu em Biodiversidade, Ambiente e Saúde. Caxias, MA, Brasil.Universidade Estadual do Maranhão - Campus Caxias. Programa de Pós‑graduação Strictu Sensu em Biodiversidade, Ambiente e Saúde. Caxias, MA, Brasil.Universidade Federal do Maranhão. Programa de Pós‑graduação Strictu Sensu em Saúde e Ambiente. São Luís, MA, Brasil.Universidade Federal do Maranhão. Programa de Pós‑graduação Strictu Sensu em Saúde e Ambiente. São Luís, MA, Brasil.Visceral leishmaniasis (VL) is an infectious disease predominant in countries located in the tropics. The prediction of occurrence of infectious diseases through epidemiologic modeling has revealed to be an important tool in the understanding of its occurrence dynamic. The objective of this study was to develop a forecasting model for the incidence of VL in Maranhão using the Seasonal Autoregressive Integrated Moving Average model (SARIMA). We collected monthly data regarding VL cases from the National Disease Notification System (SINAN) corresponding to the period between 2001 and 2018. The Box‑Jenkins method was applied in order to adjust a SARIMA prediction model for VL general incidence and by sex (male or female) for the period between January 2019 and December 2013. For 216 months of this time series, 10,431 cases of VL were notified in Maranhão, with an average of 579 cases per year. With regard to age range, there was a higher incidence among the pediatric public (0 to 14 years of age). There was a predominance in male cases, 6437 (61.71%). The Box‑Pierce test figures for overall, male and female genders supported by the results of the Ljung‑Box test suggest that the autocorrelations of residual values act as white noise. Regarding monthly occurrences in general and by gender, the SARIMA models (2,0,0) (2,0,0), (0,1,1) (0,1,1) and (0,1,1) (2, 0, 0) were the ones that mostly adjusted to the data respectively. The model SARIMA has proven to be an adequate tool for predicting and analyzing the trends in VL incidence in Maranhão. The time variation determination and its prediction are decisive in providing guidance in health measure intervention

Energy levels and lysine, calcium and phosphorus adjustments on broiler nutrient digestibility and performance

Abstract Chicken broilers digestibility and performance fed with different ME levels, with and without adjustments of digestible lysine, calcium, and available phosphorus, were evaluated. For digestibility, 210 male Cobb 500 chicken broilers were used and distributed into a 3x2+1 factorial arrangement, with three ME levels (3050; 3125 and 3200 kcal/kg) with and without nutrient adjustment, plus one control treatment (2975 kcal ME/kg), totaling seven treatments including six repetitions with five birds into each repetition. For initial performance, 1120 birds were distributed randomly with eight replications within treatments and 20 birds for each replication. For final performance, 1008 chickens were distributed with eight replications and 18 birds for each replication. The DCDM and DCCP were improved (P0.05) between energy and nutrient adjustment, but the increase in energy levels improved the feed conversion ratio (FCR=1.370). Increasing energy density with nutrient adjustment improves both nutrient utilization and bird performance