Interação da Serotonina (5-hidroxitriptamina - 5-HT) na Doença Diverticulite

Introduction: The gastrointestinal tract is involved by a complex system that has paramount importance in daily intestinal homeostasis. The intestine is responsible for the production of serotonin and a low and/or high concentration of this hormone may be the cause of diverticulitis. Objective: To show the hypothesis of serotonin in diverticulitis disease. Methodology: Bibliographic research was carried out to construct this integrative review in the MEDLINE/PubMed (via the National Library of Medicine), ScienceDirect (Elsevier), SCOPUS (Elsevier) and SciELO.ORG databases and Google Scholar. Result: 88 articles were found following the research methods, none of the articles were excluded, then they were divided among the authors, read by complete, remaining 7 for construction of the research, being presented in the table with the main hypothesis of the authors. Conclusion: Due to the lack of research and the delimitations of studies relating serotonin and gastrointestinal diseases, this article showed that it is essential to develop more studies to demonstrate the real relationship of the emergence of this pathology with hormone which as a hypothesis of 5-hydroxytryptamine in the inflammation of diverticulitis.Introdução: O trato gastrointestinal é envolvido por um complexo sistema que tem suma importância no cotidiano na homeostasia intestinal. O intestino é responsável pela produção da serotonina e a baixa e/ou alta concentração desse hormônio, talvez seja, o causador da doença diverticulite. Objetivo: mostrar a hipótese da serotonina na doença diverticulite. Metodologia: Foi realizado o levantamento bibliográfico para construção dessa revisão integrativa nas bases de dados MEDLINE/PubMed (via National Library of Medicine), ScienceDirect (Elsevier), SCOPUS (Elsevier) e SciELO.ORG e google acadêmico. Resultado: Foram encontrados 88 artigos seguindo os métodos de pesquisa, nenhum dos artigos foram excluídos, então foram divididos entre os autores, lidos por completos, restando 7 para construção das pesquisas, sendo apresentado na tabela com a principal hipótese dos autores. Conclusão: Devido a carência das pesquisas e as delimitações dos estudos relacionando serotonina e as doenças gastrointestinais, esse artigo demonstrou que é fundamental desenvolver mais estudos para evidenciar a real relação do surgimento dessa patologia com hormônio qual como hipótese da 5-hidroxitriptamina na inflamação da diverticulite

Phytochemical screening of the Dicksonia sellowiana leaves and its structures

Abstract Dicksonia sellowiana (Dicksoniaceae) is a tree fern characteristic of the mixed ombrophilous forests of southern Brazil in the Atlantic Forest. Due to its extensive use in the past for making garden pots, this species is at risk of extinction. The objective of this study was to evaluate the phytochemical composition of D. sellowiana leaves and their structures and correlate it with their antioxidant potential. Measurements of moisture content, extraction yield, preliminary phytochemical analysis, chemometric analysis by 1H NMR PCA, UPLC-PDA-MS analysis, total polyphenol content, and antioxidant activity were conducted on the leaves and their structures. The phytochemical composition confirmed the presence of polyphenols, including tannins and flavonoids (derived from kaempferol), with higher concentrations in the pinna and lower in the rachis. The pinnule exhibits high diversity and concentration of phytochemical compounds, which justify its antioxidant activity due to the presence of polyphenols. In conclusion, this study highlights that the pinnae and leaves of D. sellowiana exhibit a similar and more diverse phytochemical composition compared to the other evaluated structures, showing higher concentrations of polyphenols and antioxidant activity. The results reinforce the preservation of the endangered species and its potential as a resource for pharmacological and nutritional phytochemical compounds