Verslag van het 2e interlaboratoriumonderzoek bepaling van lebweibestanddelen met behulp van reversed phase hogeprestatievloeistofchromatografie

Met brief nr. 0587 van het RIKILT dd. 1988-02-16 werden de resultaten verzonden van de "proefronde" bepaling van lebweibestanddelen met behulp van reversed phase hogeprestatievloeistofchromatografie (RP HPLC). Uit dat onderzoek bleek dat alle deelnemende laboratoria in staat moesten worden geacht lebweibestanddelen in melkpoeders te kunnen bepalen met behulp van RP HPLC. Daarom werd besloten een tweede interlaboratoriumonderzoek te houden ter vaststelling van de precisie (herhaalbaarheid en reproduceerbaarheid) van de methode

Characterization of clean and fouled ultrafiltration membranes

Much research into the fundamentals of membrane formation and separation has been performed in order to improve the efficiency of the manufacture of ultrafiltration membranes. Determination of the membrane characteristics is a key problem in these investigations. In this paper, we report on a study of membrane morphology by fractional rejection measurements, using low molecular weight saccharides as the test solute, and by electron microscopy. Using a simple model for solute/solvent transport through cylindrical pores, a “characteristic pore size” was derived from saccharide rejection data. This pore size of a hypothetical isoporous membrane, interpreting the measured separation characteristics, provides a promising means of describing differences between membranes with respect to pore size and pore size changes caused by solute adsorption. From high resolution electron micrographs, information was obtained on the skin layer morphologies and, for some membranes the sizes of the larger pores could be estimated

Effect of long-term Sodium Hypochlorite Cleaning on Silicon Carbide Ultrafiltration Membranes Prepared by Low-Pressure Chemical Vapor Deposition

Sodium hypochlorite (NaClO) is widely used for the chemical cleaning of fouled ultrafiltration (UF) membranes. Various studies performed on polymeric membranes demonstrate that long-term (&gt;100 h) exposure to NaClO deteriorates the physicochemical properties of the membranes, leading to reduced performance and service life. However, the effect of NaClO cleaning on ceramic membranes, particularly the number of cleaning cycles they can undergo to alleviate irreversible fouling, remains poorly understood. Silicon carbide (SiC) membranes have garnered widespread attention for water and wastewater treatment, but their chemical stability in NaClO has not been studied. Low-pressure chemical vapor deposition (LP-CVD) provides a simple and economical route to prepare/modify ceramic membranes. As such, LP-CVD facilitates the preparation of SiC membranes: (a) in a single step; and (b) at much lower temperatures (700–900 °C) in comparison with sol-gel methods (ca. 2000 °C). In this work, SiC ultrafiltration (UF) membranes were prepared via LP-CVD at two different deposition temperatures and pressures. Subsequently, their chemical stability in NaClO was investigated over 200 h of aging. Afterward, the properties and performance of as-prepared SiC UF membranes were evaluated before and after aging to determine the optimal deposition conditions. Our results indicate that the SiC UF membrane prepared via LP-CVD at 860 °C and 100 mTorr exhibited excellent resistance to NaClO aging, while the membrane prepared at 750 °C and 600 mTorr significantly deteriorated. These findings not only highlight a novel preparation route for SiC membranes in a single step via LP-CVD, but also provide new insights about the careful selection of LP-CVD conditions for SiC membranes to ensure their long-term performance and robustness under harsh chemical cleaning conditions.</div

Ketogenic diet for epilepsy and obesity:Is it the same?

The term “ketogenic diet” (KD) is used for a wide variety of diets with diverse indications ranging from obesity to neurological diseases, as if it was the same diet. This terminology is confusing for patients and the medical and scientific community. The term “ketogenic” diet implies a dietary regimen characterized by increased levels of circulating ketone bodies that should be measured in blood (beta-hydroxybutyrate), urine (acetoacetate) or breath (acetone) to verify the “ketogenic metabolic condition”. Our viewpoint highlights that KDs used for epilepsy and obesity are not the same; the protocols aimed at weight loss characterized by low-fat, low-CHO and moderate/high protein content are not ketogenic by themselves but may become mildly ketogenic when high calorie restriction is applied. In contrast, there are standardized protocols for neurological diseases treatment for which ketosis has been established to be part of the mechanism of action. Therefore, in our opinion, the term ketogenic dietary therapy (KDT) should be reserved to the protocols considered for epilepsy and other neurological diseases, as suggested by the International Study Group in 2018. We propose to adjust the abbreviations in VLCHKD for Very Low CarboHydrate Ketogenic Diet and VLEKD for Very Low Energy Ketogenic Diet, to clarify the differences in dietary composition. We recommend that investigators describe the researchers describing efficacy or side effects of KDs, to clearly specify the dietary protocol used with its unique acronym and level of ketosis, when ketosis is considered as a component of the diet's mechanism of action.</p

Effects of correcting metabolic acidosis on muscle mass and functionality in chronic kidney disease:a systematic review and meta-analysis

Metabolic acidosis unfavourably influences the nutritional status of patients with non-dialysis dependent chronic kidney disease (CKD) including the loss of muscle mass and functionality, but the benefits of correction are uncertain. We investigated the effects of correcting metabolic acidosis on nutritional status in patients with CKD in a systematic review and meta-analysis. A search was conducted in MEDLINE and the Cochrane Library from inception to June 2023. Study selection, bias assessment, and data extraction were independently performed by two reviewers. The Cochrane risk of bias tool was used to assess the quality of individual studies. We applied random effects meta-analysis to obtain pooled standardized mean difference (SMD) and 95% confidence intervals (CIs). We retrieved data from 12 intervention studies including 1995 patients, with a mean age of 63.7 ± 11.7 years, a mean estimated glomerular filtration rate of 29.8 ± 8.8 mL/min per 1.73 m2, and 58% were male. Eleven studies performed an intervention with oral sodium bicarbonate compared with either placebo or with standard care and one study compared veverimer, an oral HCl-binding polymer, with placebo. The mean change in serum bicarbonate was +3.6 mEq/L in the intervention group and +0.4 mEq/L in the control group. Correcting metabolic acidosis significantly improved muscle mass assessed by mid-arm muscle circumference (SMD 0.35 [95% CI 0.16 to 0.54], P &lt; 0.001) and functionality assessed with the sit-to-stand test (SMD −0.31 [95% CI −0.52 to 0.11], P = 0.003). We found no statistically significant effects on dietary protein intake, handgrip strength, serum albumin and prealbumin concentrations, and blood urea nitrogen. Correcting metabolic acidosis in patients with CKD improves muscle mass and physical function. Correction of metabolic acidosis should be considered as part of the nutritional care for patients with CKD.</p

Professional farmer collectives for effective agri-environmental management: an assessment

In 2013 the EU Common Agricultural Policy (CAP) enabled groups of farmers to be applicants and final beneficiaries of Agri-environmental schemes (AES). The Dutch government went one step further, ruling that only groups of farmers (farmer collectives) could be beneficiaries of AES. The changing role of farmer groups or farmer collectives comes with a variety of challenges. Using the lens of professionalization, we investigated the professionalization of the Dutch farmer collectives after three years of coordinating AESs, with the aim of ascertaining how professional the collectives are and how any differences in professionalism can be explained. The experience of the Dutch collectives is relevant to other groups of farmers in Europe who are starting or are engaged in the process of self-organization and professionalization, as well as to the further development of the Dutch collectives. Our assessment revealed that there are different types of professional collectives, depending on the situation. Most of the collectives scored excellently on the organizational and occupational criteria with an internal focus. All the collectives have criteria that could be improved. There are differences in professionalization based on history, resources and scale

Degree of tumour vascularity correlates with drug accumulation and tumour response upon TNF-α-based isolated hepatic perfusion

Isolated hepatic perfusion (IHP) with melphalan with or without tumour necrosis factor alpha (TNF-α) is currently performed in clinical trials in patients with hepatic metastases. Previous studies led to the hypothesis that the use of TNF-α in isolated limb perfusion causes specific destruction of tumour endothelial cells and thereby induces an increased permeability of tumour vasculature. However, whether TNF-α contributes to the therapeutic efficacy in IHP still remains unclear. In an in vivo rat liver metastas