1 research outputs found
Copper-Containing Catalytic Amyloids Promote Phosphoester Hydrolysis and Tandem Reactions
Self-assembly
of short de novo designed peptides gives rise to
catalytic amyloids capable of facilitating multiple chemical transformations.
We show that catalytic amyloids can efficiently hydrolyze paraoxon,
which is a widely used, highly toxic organophosphate pesticide. Moreover,
these robust and inexpensive metal-containing materials can be easily
deposited on various surfaces, producing catalytic flow devices. Finally,
functional promiscuity of catalytic amyloids promotes tandem hydrolysis/oxidation
reactions. High efficiency discovered in a very small library of peptides
suggests an enormous potential for further improvement of catalytic
properties, both in terms of catalytic efficiency and substrate scope