Engineering the Frequency Spectrum of Bright Squeezed Vacuum via Group Velocity Dispersion in an SU(1,1) Interferometer

Bright squeezed vacuum, a promising tool for quantum information, can be generated by high-gain parametric down-conversion. However, its frequency and angular spectra are typically quite broad, which is undesirable for applications requiring single-mode radiation. We tailor the frequency spectrum of high-gain parametric down-conversion using an SU(1,1) interferometer consisting of two nonlinear crystals with a dispersive medium separating them. The dispersive medium allows us to select a narrow band of the frequency spectrum to be exponentially amplified by high-gain parametric amplification. The frequency spectrum is thereby narrowed from (56.5 +- 0.1) to (1.22 +- 0.02) THz and, in doing so, the number of frequency modes is reduced from approximately 50 to 1.82 +- 0.02. Moreover, this method provides control and flexibility over the spectrum of the generated light through the timing of the pump.Comment: 6 pages, 5 figure

Concentration, composition, and genesis of hydrocarbons in bottom sediments of the Chernaya River estuarine zone (Sevastopol, the Black Sea)

The “river-sea” geochemical barrier is studied slightly in terms of the variety of pollutants, sedimentation, and degradation. At the same time, problems related to oil pollution, in particular the genesis of hydrocarbons, are almost never covered. This study was dedicated to the origin, concentration, and composition of hydrocarbons in the bottom sediments of the Chernaya River (Black Sea, Crimea) estuarine zone. The features of the marginal filter zone of the river were considered. N-alkanes in the range of C11-C36 were identified in the bottom sediments of the studied water area. It was noted that there was persistent oil pollution (degraded hydrocarbons) in the water area of Sevastopol Bay, adjacent to the confluence of the river. The accumulation of terrestrial material increased as it moved from the river to the sea. The application of various molecular markers displayed the predominately allochthonous origin of the hydrocarbons in the bottom sediments. As a result of the study of molecular markers by using principal component analysis (PCA) and analysis of variance (ANOVA) analysis, three leading factors responsible for hydrocarbon input to the bottom sediments water area were identified. The first one (36.53 % of the total variation) was associated with n-alkanes of natural and anthropogenic input. The second factor (19.52 % variation) was associated with allochthonous organic matter, including petroleum and bacterial destruction. The third factor (10.74 %) was associated with mainly allochthonous routes of organic substances entering the bottom sediments of the water area

Television of the Republic of Tatarstan as an instrument of national identity

The study of the role of regional television in national identification has gained particular relevance in the context of contemporary processes of mediatisation and globalisation. The theoretical significance of the results is related to the identification of the techniques of media identification in a historical perspective, as well as to the discovery of the factors influencing the identification process. The authors present the results of a study of both the historical experience of the development of state television in the territory of Tatarstan and the modern practice of the TV channel “Tatarstan - New Century”, which is currently considered the main national channel in the republic. The degree to which the topic of regional television development in Russia and around the world has been studied in terms of the specifics of national broadcasting, and studies which address the problem of ethnic identification through the media have been taken into account. A large body of empirical material was used to identify traditions and innovations in the activities of regional television, whose mission is to preserve and develop the native language, cultural and historical heritage. Through the analysis of empirical data the continuity of regional television traditions in relation to the national component is shown for the first time

Molecular mechanisms of the effect of standardized placental hydrolysate peptides on mitochondria functioning

Background. Human placenta hydrolysates (HPH), the study of which was initiated by the scientific school of Vladimir P. Filatov, are currently being investigated using modern proteomic technologies. HPH is a promising tool for maintaining the function of mitochondria and regenerating tissues and organs with a high content of mitochondria (liver, heart muscle, skeletal muscles, etc.). The molecular mechanisms of action of HPH are practically not studied. Aim. Identification of mitochondrial support mitochondrial function-supporting peptides in HPH (Laennec, produced by Japan Bioproducts). Materials and methods. Data on the chemical structure of the peptides were collected through a mass spectrometric experiment. Then, to establish the amino acid sequences of the peptides, de novo peptide sequencing algorithms based on the mathematical theory of topological and metric analysis of chemographs were applied. Bioinformatic analysis of the peptide composition of HPH was carried out using the integral protein annotation method. Results. The biological functions of 41 peptides in the composition of HPH have been identified and described. Among the target proteins, the activity of which is regulated by the identified peptides and significantly affects the function of mitochondria, are caspases (CASP1, CASP3, CASP4) and other proteins regulating apoptosis (BCL2, CANPL1, PPARA), MAP kinases (MAPK1, MAPK3, MAPK4, MAPK8, MAPK9 , MAPK10, MAPK14), AKT1/GSK3B/MTOR cascade kinases, and a number of other target proteins (ADGRG6 receptor, inhibitor of NF-êB kinase IKKE, pyruvate dehydrogenase 2/3/4, SIRT1 sirtuin deacetylase, ULK1 kinase). Conclusion. HPH peptides have been identified that promote inhibition of mitochondrial pore formation, apoptosis, and excessive mitochondrial autophagy under conditions of oxidative/toxic stress, chronic inflammation, and/or hyperinsulinemia

How Morphology of the Human Pluripotent Stem Cells Determines the Selection of the Best Clone

The application of patient-specific human induced pluripotent stem cells (hiPSCs) has a great perspective for the development of personalized medicine. More than 10 hiPSCs clones can be obtained from one patient but not all of them are able to undergo directed differentiation with the same efficiency. Beside, some clones are even refractory to certain directions of differentiation. Therefore, the selection of the “best” or “true” hiPSC clone is very important, but this remains a challenge. Currently, this selection is based mostly on the clone’s morphological characteristics. Earlier, using methods of mathematical analysis and deep machine learning, we showed the fundamental possibility for selecting the best clone with about 89% accuracy based on only two to three morphological features. In this chapter, we will expand on how the morphological characteristics of various hiPSCs clones, the so-called “morphological portrait,” are reflected by their proteome. By reviewing previously published data and providing the new results, we will highlight which cytoskeletal proteins are responsible for the establishment of the “good” morphological phenotype. Finally, we will suggest further directions in this research area