The map of possible interactions between components of MI-associated biallelic combination <i>IFNG</i> and <i>PTGS1</i> (black circles) and ten relative partners (gray circles) generated by GeneMania online software [45].

<p>Possible physical interactions (pink), co-expression (violet), pathway (blue), genetic interactions (green), and shared protein domains (yellow) are shown. IDO1 –indoleamine 2,3–dioxygenase 1; IFNG–interferon gamma; IFNGR1 –interferon gamma receptor 1; IFNGR2 –interferon gamma receptor 2; IRF1 –interferon regulatory factor 1; MPO–myeloperoxidase; PTGIS–prostaglandin I2 (prostacyclin) synthase; PRKCD–protein kinase C delta; PTGS1 –prostaglandin–endoperoxide synthase 1; PTGS2 –prostaglandin–endoperoxide synthase 2; PTPN2 –protein tyrosine phosphatase, non–receptor type 2; PTPN6 –protein tyrosine phosphatase, non–receptor type 6.</p

ROC curves demonstrate usefulness of the additive composite model built from all identified genetic markers.

<p><b>A</b>. Comparing performance of the composite model to the performance of each single marker in the Moscow discovery sample. Combining the high specificity of <i>CRP</i> and <i>IFNG</i>+<i>PTGS</i> predictors (the left hump) with relatively high sensitivity of <i>TGFB1</i> and <i>FGB</i> (the right hump) yields a much better classifier. <b>B</b>. Performance of the model stays the same when tested on the independent replication sample (Bashkortostan).</p