Organisational economic mechanism of circular subsoil use

One problem about developing circular economy in the mineral resources sector is the absence of a methodological approach to forming an organisational economic mechanism for circular subsoil use in Russia and its regions which specialise in the extraction of minerals. The paper aims to create such an approach. The concept of circular economy and theoretical propositions of natural resources economics and environmental management constitute the methodological basis of the research. The methods include analysis, synthesis, and inductive reasoning. The paper justifies the application of the terms “organisational economic mechanism”, “circular subsoil use”, and “organisational economic mechanism of circular subsoil use” and provides them with definitions. Then, the article identifies organisational, legal and economic factors affecting the organisational economic mechanism, as well as formulates principles of balancing it and ensuring its efficiency. Proceeding from these factors and principles the authors justify their selection of tools: 1) organisational and managerial ones targeted at forming, regulating, and coordinating the activities of circular processes’ participants; 2) economic ones that create material incentives for developing circular economy in the subsoil use. According to the research results, there are two groups of indicators showing the effectiveness of using these tools: general economic (macroand meso-) and commercial (microeconomic) indicators. The developed methodology allows ensuring the effectiveness and efficiency of the state management of secondary resources and waste generated by mineral extraction

Study of chromosome composition of the southern Ural genotypes of Prunus pumila L. by various methods

Prunus pumila L. is a winter-hardy Siberian species widely used in kitchen-gardens, as well as in nurseries as a seed stock for plums and apricots and development of hybrids for stocks of these cultures. Rare cases of emergence of polyploids among introduced seedlings are known. Chromosome numbers of 11 morphologically different plants of this species from Chelyabinsk Oblast were studied in comparison with some plants from Barnaul with already known ploidy by cytological and cytometric methods. With the help of both methods it was established that all plants from Chelyabinsk Oblast turned out to be diploids. Ploidy of the control specimens from Barnaul was supported by the cytometric method. A rare emergence of polyploids when introducing P. pumila in the climatic conditions differing from the natural ones was confirmed

Study of chromosome composition of the southern Ural genotypes of

Prunus pumila L. is a winter-hardy Siberian species widely used in kitchen-gardens, as well as in nurseries as a seed stock for plums and apricots and development of hybrids for stocks of these cultures. Rare cases of emergence of polyploids among introduced seedlings are known. Chromosome numbers of 11 morphologically different plants of this species from Chelyabinsk Oblast were studied in comparison with some plants from Barnaul with already known ploidy by cytological and cytometric methods. With the help of both methods it was established that all plants from Chelyabinsk Oblast turned out to be diploids. Ploidy of the control specimens from Barnaul was supported by the cytometric method. A rare emergence of polyploids when introducing P. pumila in the climatic conditions differing from the natural ones was confirmed

Genetically Encoded Self-Assembling Protein Nanoparticles for the Targeted Delivery In Vitro and In Vivo

Targeted nanoparticles of different origins are considered as new-generation diagnostic and therapeutic tools. However, there are no targeted drug formulations within the composition of nanoparticles approved by the FDA for use in the clinic, which is associated with the insufficient effectiveness of the developed candidates, the difficulties of their biotechnological production, and inadequate batch-to-batch reproducibility. Targeted protein self-assembling nanoparticles circumvent this problem since proteins are encoded in DNA and the final protein product is produced in only one possible way. We believe that the combination of the endless biomedical potential of protein carriers as nanoparticles and the standardized protein purification protocols will make significant progress in “magic bullet” creation possible, bringing modern biomedicine to a new level. In this review, we are focused on the currently existing platforms for targeted self-assembling protein nanoparticles based on transferrin, lactoferrin, casein, lumazine synthase, albumin, ferritin, and encapsulin proteins, as well as on proteins from magnetosomes and virus-like particles. The applications of these self-assembling proteins for targeted delivery in vitro and in vivo are thoroughly discussed, including bioimaging applications and different therapeutic approaches, such as chemotherapy, gene delivery, and photodynamic and photothermal therapy. A critical assessment of these protein platforms’ efficacy in biomedicine is provided and possible problems associated with their further development are described