Association of two SNPs in <i>FBN-1</i> with Thoracic Aortic Dissection.

<p>*Adjusted for sex and study center.</p>†<p>Adjusted for sex, study center, age, hypertension, and smoking.</p

Association of the SNPs in <i>FBN-1</i> with Thoracic Aortic Dissection or Aneurysm.

<p>*Adjusted for sex and study center.</p>†<p>Adjusted for sex, study center, age, hypertension, and smoking.</p

Characteristics of Dissection, Non-dissecting Aneurysm Cases, and Controls.

<p>*P value for Dissection cases vs. controls;</p>†<p>P value for Non-dissecting aneurysm cases vs. controls.</p><p>Data presented as mean ± standard deviation for age and as a number (%) of subjects for other variables.</p><p><i>P</i> values are from Fisher exact test, except those for age, which are from the Wilcoxon rank sum test.</p

Association of two SNPs in <i>FBN-1</i> with Non-dissecting Thoracic Aortic Aneurysm.

<p>*Adjusted for sex and study center.</p>†<p>Adjusted for sex, study center, age, hypertension, and smoking.</p

Genomic region of rs13279522.

<p>A ∼500 kb region centered around rs13279522 is from UCSC browser (<a href="http://genome.ucsc.edu" target="_blank">http://genome.ucsc.edu</a>). Linkage Disequilibrium (LD) information is color-coded at the bottom, genes (horizontal blue lines) and exons (vertical blue lines) are indicated above the LD representation. Vertical orange line correspond to the negative base 10 logarithm of the P value from a case only analysis of CARE and WOSCOPS for SNPs in this region. The location of rs13279522 is indicated by a black arrow.</p

Study design.

<p>A flow chart outlining the patients and SNPs investigated in the 2 stages of the study.</p

Most significant SNPs associated with differential response to pravastatin therapy in a case-only combined analysis of CARE and WOSCOPS.

<p>Most significant SNPs associated with differential response to pravastatin therapy in a case-only combined analysis of CARE and WOSCOPS.</p

Individual and Combined analysis of 54 SNPs in CARE, WOSCOPS, and PROSPER/PHASE.

*<p>case-only data in CARE and WOSCOPS.</p>†<p>case-only data in WOSCOPS.</p

Baseline characteristics of study participants.

<p>± values are standard deviation.</p

Risk reduction according to genotype for rs13279522.

<p>Risk estimate and 95% confidence intervals are indicated for each genotype group in each study, as well as for the combined analysis of the studies. The number of individuals in each group is indicated.</p