Risk factors associated with default from multi- and extensively drug-resistant tuberculosis treatment, uzbekistan: a retrospective cohort analysis.

The Médecins Sans Frontières project of Uzbekistan has provided multidrug-resistant tuberculosis treatment in the Karakalpakstan region since 2003. Rates of default from treatment have been high, despite psychosocial support, increasing particularly since programme scale-up in 2007. We aimed to determine factors associated with default in multi- and extensively drug-resistant tuberculosis patients who started treatment between 2003 and 2008 and thus had finished approximately 2 years of treatment by the end of 2010

Factors associated with default identified by multivariate analysis.

<p>OR = odds ratio. XDR = extensively drug-resistant. Cat II = category II treatment.</p

Baseline proportions and association of factors with default by univariate analysis.

<p>BMI = body-mass index. MDR = multidrug-resistant. Cat I = category I treatment. Cat II = category II treatment. XDR = extensively drug-resistant.</p