The interaction of homophthalic anhydride with (triphenylphosphoranylidene)acetates

In the study of the interaction of homo­phthalic anhydride and methyl (triphenyl­phosphoranylidene)­acetate, along with (1-oxo-1H-isochromen-3‑yl)acetate obtaining, two minor products – (1,3-dioxo-1,2,3,4-tetrahydronaphthalene-2-yl)acetate and 2‑((1‑oxo-1H-isochromen-3-yl)methyl)benzoic acid – had been isolated. The action of tert‑butyl (triphenyl­phosphoranylidene)­acetate on homo­phthalic anhydride didn’t lead to Wittig reaction; the encumbered ylide demonstrated only its basicity, and products of homo­phthalic anhydride self-condensation – 2‑((1‑oxo-1H-isochromen-3-yl)methyl)-benzoic acid and 12-hydroxy-5H-dibenzo[c,g]chromen-5-one – were formed

1,2-Disubstituted Bicyclo[2.1.1]hexanes as Bioisosteres of the ortho-substituted Benzene

1,2-Disubstitued bicyclo[2.1.1]hexanes have been designed, synthesized, and validated as a new generation of saturated bioisosteres of ortho-substituted benzenes. Incorporation of the bicyclo[2.1.1]hexane core into the structure of agrochemicals Boskalid (BASF), Bixafen (Bayer CS), and Fluxapyroxad (BASF) gave saturated analogs that exhibited a high antifungal activity

Spiro[3.3]heptane as a Non-collinear Benzene Bioisostere

Spiro[3.3]heptane can mimic the mono-, meta- and para-substituted phenyl rings in drugs

Bicyclic Bioisosteres of Piperidine: Version 2.0

1-Azaspiro[3.3]heptanes were synthesized, characterized, and validated biologically in vivo as a new generation of saturated piperidine bioisosteres