The history of hydrocarbon filling of Danish chalk fields

In an oil reservoir, the geometry of the interface between water and oil is critical in determining the volume of oil trapped below the top seal. If the interface is planar and horizontal, the volume calculation is fairly simple, but if the interface is tilted or undulating, estimation of the volume of the trapped oil is complex as it depends on the combined structural and fluid contact geometry. Since accumulation of the oil may take place over a time span of several million years, while the reservoir is experiencing burial and compaction, the charge history must be studied using dynamic methods that account for these changes and for flow in both the oil and water phases. These processes have been studied quantitatively at the Geological Survey of Denmark and Greenland (GEUS) in a project that has combined the burial model with a fluid flow simulator. The modelling study shows that filling of a chalk reservoir can have a very long and complex history dominated by very low fluid flow rates (cm/year). The resulting modelled present-day situation exhibits a very irregular oil distribution and a non-planar geometry of the fluid contacts, and shows marked similarities to that shown by the field data

Degenerative encephalopathy in Nova Scotia Duck Tolling Retrievers presenting with a rapid eye movement sleep behavior disorder

BACKGROUND: Neurodegenerative diseases are a heterogeneous group of disorders characterized by loss of neurons and are commonly associated with a genetic mutation. HYPOTHESIS/OBJECTIVES: To characterize the clinical and histopathological features of a novel degenerative neurological disease affecting the brain of young adult Nova Scotia Duck Tolling Retrievers (NSDTRs). ANIMALS: Nine, young adult, related NSDTRs were evaluated for neurological dysfunction and rapid eye movement sleep behavior disorder. METHODS: Case series review. RESULTS: Clinical signs of neurological dysfunction began between 2 months and 5 years of age and were progressive in nature. They were characterized by episodes of marked movements during sleep, increased anxiety, noise phobia, and gait abnormalities. Magnetic resonance imaging documented symmetrical, progressively increasing, T2‐weighted image intensity, predominantly within the caudate nuclei, consistent with necrosis secondary to gray matter degeneration. Abnormalities were not detected on clinicopathological analysis of blood and cerebrospinal fluid, infectious disease screening or urine metabolite screening in most cases. Postmortem examination of brain tissue identified symmetrical malacia of the caudate nuclei and axonal dystrophy within the brainstem and spinal cord. Genealogical analysis supports an autosomal recessive mode of inheritance. CONCLUSIONS AND CLINICAL IMPORTANCE: A degenerative encephalopathy was identified in young adult NSDTRs consistent with a hereditary disease. The prognosis is guarded due to the progressive nature of the disease, which is minimally responsive to empirical treatment

COAST Development Group's international consensus guidelines for the treatment of canine osteoarthritis

This report describes consensus guidelines and recommendations for the treatment of canine osteoarthritis (OA) according to the “Canine OsteoArthritis Staging Tool excluding radiography” (COASTeR) stage of OA, by the COAST Development Group. The recommendations are based on evidence-based medicine and clinical experience and are proposed with international relevance in mind. The aim is to provide veterinarians with a practical reference to consolidated information and to support the development of patient-specific OA management protocols and informed treatment choices based on the stage of OA