Baseline characteristics of the study population. IBD: inflammatory bowel disease.

<p>Baseline characteristics of the study population. IBD: inflammatory bowel disease.</p

Number of events, incidence rates per 1000 person-years, adjusted rate ratios (RRs) and 95% confidence intervals (CIs).

<p>The composite endpoint was myocardial infarction, stroke and cardiovascular death combined. IBD: inflammatory bowel disease. The model was adjusted for age, gender, co-morbidity, cardiovascular medication and socioeconomic status.</p

Risk of myocardial infarction, stroke and cardiovascular death stratified by inflammatory bowel disease activity.

<p>CI: confidence interval. RR: Rate ratio.</p

Disease activity periods and follow-up time in study cohort with inflammatory bowel disease (IBD).

<p>Disease activity periods and follow-up time in study cohort with inflammatory bowel disease (IBD).</p

Flowchart for the study population, IBD: Inflammatory bowel disease.

<p>Flowchart for the study population, IBD: Inflammatory bowel disease.</p

Baseline characteristics of study population.

*<p>Defined as combined treatment with at least two of the following classes of antihypertensive drugs: α adrenergic blockers, non-loop diuretics, vasodilators, β blockers, calcium channel blockers, and renin-angiotensin system inhibitors.</p>**<p>According to the Ontario Acute Myocardial Infarction Prediction Rules by diagnosis from the index MI admission and 1 year prior to admission.</p>†<p>Claimed prescriptions within 180 days prior to the index MI admission.</p>‡<p>Income tertiles calculated for all women with MI in the period 1997 to 2009.</p

Categories of hormone replacement therapy.

<p>Abbreviation: HRT, hormone replacement therapy; ATC, Anatomical Therapeutic Chemical system.</p>*<p>Continuous combined estrogen/progestogen: daily doses of both estrogen and progestogen. Cyclic combined estrogen/progestogen: daily doses of estrogen and intermittent periods with daily doses of progestogen.</p

Study population.

<p>Red box indicates the final study population.</p

Hazard ratios and unadjusted incidence rates of atrial fibrillation.

<p>Black dots with whiskers: Hazard ratio with 95% confidence interval. Hatched columns: Unadjusted incidence rates. Abbreviation: HRT, hormone replacement therapy. Hazard ratios were calculated using a multivariable Cox proportional hazards model adjusted for fixed variables of year of myocardial infarction, hypertension, and income group and time-dependent variables of revascularization, valvular disease, statins, loop diuretics, clopidogrel, anti-thyroid and glucose-lowering medication.</p

Age-stratified incidence rates per 1000 person-years.

<p>IR: incidence rate; CI: 95% confidence interval; VTE: venous thromboembolism.</p