Zerreißprobe für die Hauptschlagader : "Center for Biomedical Engineering" (CBME) arbeitet an verbessertem Vorhersagemodell für Aneurysmenrupturen

Krankhafte Erweiterungen der Bauchschlagader (Aorten-Aneurysmen), sind wie tickende Zeitbomben: Wenn sie platzen, stirbt der Betroffene oft noch bevor er ein Krankenhaus erreicht an inneren Blutungen. Niemand kann mit Bestimmtheit vorhersagen, wann dies eintritt, aber gemeinsam mit Ingenieuren finden Gefäßchirurgen jetzt neue Anhaltspunkte dafür, wann eine Operation ratsam ist

Whole-farm profit and the optimum maternal liveweight profile of Merino ewe flocks lambing in winter and spring are influenced by the effects of ewe nutrition on the progeny's survival and lifetime wool production

Profitability of sheep production systems in southern Australia is optimised at a stocking rate that provides adequate nutrition for breeding ewes and enables efficient utilisation of grown pasture and supplements. In this paper we used bio-economic modelling to develop optimum liveweight1 profiles for spring-lambing Merino ewes in different environments. The modelling included the impacts of the ewe liveweight profile on the production of the ewe and the survival and lifetime wool production of her progeny. Fifteen ewe liveweight profiles were analysed for each region to determine the profitability of varying ewe liveweight at joining, varying rate of loss of liveweight after joining and the rate of gain in liveweight from the minimum to lambing. The analyses support the hypotheses that whole-farm profitability is sensitive to the liveweight profile of Merino ewe flocks and that there is a liveweight profile that maximises whole-farm profit. The variation between the most and least profitable ewe liveweight profile was $690002 per farm ($14.30/ewe) for south-west Victoria, $51000 per farm ($8.70/ewe) for Great Southern Western Australia and $33300 per farm ($9.70/ewe) for southern New South Wales. The changes in profit were due to differences in costs of feeding to achieve the ewe liveweight profile and its influence on the production of both the ewes and their progeny. Failure to include the impacts of liveweight profile on progeny survival and lifetime wool production incorrectly identifies the optimum ewe liveweight profile and provided inaccurate estimates of profitability. The optimum liveweight profiles for ewes lambing in spring were similar for all three regions and insensitive to changing commodity prices, pasture productivity and management. The optimum profile was to join ewes at ∼90% of the standard reference weight of the genotype, lose a small amount of weight after joining and regain weight in late pregnancy to return to the joining weight by lambing. Regaining the liveweight lost in early pregnancy by lambing is the most important target to achieve. The cost per farm of missing this liveweight target by 1 kg was $13000 ($2.60/ewe) for south-west Victoria, $8900 ($1.45/ewe) for Great Southern Western Australia and $5500 ($1.65/ewe) for southern New South Wales. By contrast, the cost per farm of missing the joining target by 1 kg was $5500 for south-west Victoria and less than$2000 across the other two regions. Whole-farm profit increased with increasing stocking rate up to an optimum and regardless of stocking rate there is an additional opportunity to increase whole-farm profit by up to 15% by managing ewes to achieve the optimum liveweight profile. This indicates that the optimum liveweight profile should be achieved by increasing the level of grain feeding and altering the timing of utilising the farm feed resources rather than manipulating stocking rate

Economic value of pregnancy scanning and optimum nutritional management of dry, single - and twin-bearing Merino ewes

The nutritional requirements of twin-bearing ewes are ∼25% greater than those of ewes with single fetuses during late pregnancy and nearly twice those of non-pregnant ewes. Underfeeding ewes, resulting in liveweight loss during late pregnancy, can have adverse effects on the production and survival of both the lamb and the ewe, and improving twin-lamb survival is critical to improving the overall reproductive performance of the National Merino flock. Scanning for pregnancy status and litter size allows for more precise management of the nutrition of the ewe flock according to the different nutritional needs of dry, single- and twin-bearing ewes. In the present paper, we tested the hypothesis that it is profitable to identify pregnancy status and litter size, and the optimum nutrition profiles are different for dry, single- and twin-bearing ewes. We tested this by examining a range of nutrition strategies for flocks where only the dry ewes were identified, or for flocks where the single- and twin-bearing ewes were identified. A MIDAS model set up for the Hamilton region in south-western Victoria was used for this analysis as it represents the whole flock and it includes a powerful feed-budgeting module that optimises animal and pasture management across the whole farm. The survival and production of the single- and twin-born progeny was adjusted on the basis of the liveweight profile of the single- and twin-bearing ewes. Our hypothesis was supported and profitability was increased by approximately AU$4630/farm or AU$0.80/ewe, by scanning ewes for pregnancy status and litter size, and the optimum liveweight profiles were different for dry, single- and twin-bearing ewes. The majority of the increase in profit was due to identifying litter size and being able to differentially manage the single- and twin-bearing ewes. When ewes are scanned for pregnancy status and litter size, the most profitable combination of profiles involves all ewes losing 4 kg in early pregnancy and single-bearing ewes regaining the 4 kg to lamb at their standard reference weight, twin-bearing ewes gaining 8 kg to lamb above their standard reference weight and dry ewes losing a further 4 kg to be 8 kg lighter than their standard reference weight at lambing time

Improving the nutrition of Merino ewes during pregnancy increases the fleece weight and reduces the fibre diameter of their progeny's wool during their lifetime and these effects can be predicted from the ewe's liveweight profile

Nutrition of ewes during pregnancy can have permanent impacts on the production potential of their progeny. The hypothesis tested in the experiments reported in this paper was that improving the nutrition of Merino ewes during pregnancy and lactation increases the fleece weight and reduces the fibre diameter of their progeny's wool during their lifetime. In addition, that these effects on the progeny's wool production can be predicted from the ewe's liveweight profile. At sites in Victoria and Western Australia in each of 2 years, a wide range in the liveweight and condition score profiles of Merino ewes was generated by varying the amount of supplements fed from joining to Day 100 of pregnancy and the amount of feed on offer grazed from Day 100 to weaning. The site in Victoria was based on perennial pastures and included both single- and twin-bearing ewes whereas the site in Western Australia was based on annual pastures and included single-bearing ewes only. The production and characteristics of wool from the progeny were measured until 51 months of age at the site in Victoria and 33 months of age at the site in Western Australia. The nutritional treatments and the resulting changes in ewe liveweight had significant impacts on the fleece weight and to a lesser extent the fibre diameter of wool produced by their progeny, but there were no consistent effects on other characteristics of progeny fleece wool. The fleece weight of the progeny was related to the liveweight change during pregnancy of their mothers (P 0.05) and the relationships were similar for the two experiments at each site. At the site in Victoria, a loss of 10 kg in ewe liveweight between joining and Day 100 of pregnancy reduced fleece weight by ∼0.2 kg at each shearing until 51 months of age whereas gaining 10 kg from Day 100 of pregnancy to lambing had the opposite effect. The effect of changes in ewe liveweight during late pregnancy on the fleece weight of their progeny at each shearing was of similar magnitude at the site in Western Australia. When evident, the effect of the ewe liveweight profile on the fibre diameter of progeny wool was opposite to the effect on clean fleece weight and the effect of poor nutrition in early to mid pregnancy could be completely overcome by improving nutrition during late pregnancy. Twin-born and reared progeny produced ∼0.3 kg less clean wool at each shearing (P 0.001) that was 0.3-m broader (P 0.001) than that from single-born progeny at the site in Victoria. However, the effects of varying ewe nutrition and ewe liveweight change during pregnancy on fleece weight and fibre diameter of progeny wool were similar (P 0.05) for both single- and twin-born or reared progeny. Overall, these results supported our hypothesis and it is clear that the nutritional management of Merino ewes during pregnancy is important for optimal wool production from their progeny during their lifetime

Ewe nutrition during pregnancy and birthweight of lambs has minimal impact on fat and eye muscle depth in Merino progeny

The hypothesis tested in this experiment was that Merino lambs with lower birthweights, due to poor ewe nutrition during pregnancy, would have more fat and less muscle than Merino lambs with higher birthweights. At two sites (Victoria and Western Australia) in each of 2 years, a wide range in the liveweight profiles of ewes was generated during pregnancy and lactation by varying the amount of supplements fed and feed on offer grazed. Progeny had fat and muscle depth at the C-site measured at various ages from 8 to 28 months of age. Across the four experiments, there were differences of 0.5 kg in birthweights and 8 kg in weaning weights between extreme treatments. The effects on the depth of fat and muscle were very small with fat depth increasing by 0.1-0.2 mm (5-7%) and muscle depth increasing by 0.2-0.7 mm (1-3%) when birthweights decreased by 1 kg. The effects of birthweight on fat depth are consistent with our hypothesis whereas the effects of birthweight on muscle depth are in contrast to our hypothesis. Nevertheless, the impacts of birthweight on the depth of fat and muscle measured at the C-site of progeny from Merino ewes, is unlikely to be of any commercial significance within the range of nutritional scenarios during pregnancy and lactation that are likely to be experienced within the Australian sheep industry

The birthweight and survival of Merino lambs can be predicted from the profile of liveweight change of their mothers during pregnancy

The single largest influence on the survival of lambs in the first few days of life is their birthweight. Fetal growth and birthweight are regulated by genotype of the fetus, maternal genotype, maternal nutrition and the external environment. In this paper we report the extent to which the changes in maternal liveweight during pregnancy and lactation (liveweight profile) of Merino ewes can be used to predict the birthweight and survival of their progeny to weaning. At two sites [Victoria (Vic.) ∼700 ewes and Western Australia (WA) ∼300 ewes] in each of 2 years, a similar experiment used adult Merino ewes to explore effects of nutrition from joining to Day 100 of pregnancy and from Day 100 of pregnancy to weaning. The average difference between extreme treatments at Day 100 of pregnancy were 7 kg in ewe liveweight and 0.7 of a condition score (CS) and at lambing 11.9 kg and 1.3 of a CS. This resulted in average birthweights of progeny from different treatments ranging from 4.0 to 5.4 kg and survival to weaning ranging from 68 to 92%. Across the four experiments between 68 and 85% of all lamb deaths to weaning occurred within 48 h of birth. Lambs born to ewes in CS 2 at Day 100 of pregnancy were lighter (P 0.05) in both years at the Vic. site than those from ewes in CS 3 at Day 100 of pregnancy. Lambs born to the ewes grazing a feed on offer of 800 kg DM/ha during late pregnancy were also lighter than those from other levels of feed on offer between 1100 and 3000 kg DM/ha at the Vic. site in both years and at the WA site in 1 year (P 0.001). Lambs from the 800 kg DM/ha treatment during late pregnancy at the Vic. site had a lower survival than other treatments, especially in the second year. There were no significant effects of treatments on lamb survival at the WA site; however, the results were in the same direction. The birthweight of individual lambs was significantly related to the liveweight profile of their mothers. Their liveweight at joining, change in liveweight to Day 100 of pregnancy and change in liveweight from Day 100 to lambing all contributed (P 0.05) to the prediction of the birthweight of their lambs. The responses were consistent across experimental sites and years, lamb birth rank and sex, and confirmed that the effects of poor nutrition up until Day 100 of pregnancy could be completely overcome by improving nutrition during late pregnancy. At the Vic. site, survival to 48 h was most influenced by the birthweight of the lamb and survival was significantly higher in single- than twin-born lambs and female than male lambs after adjusting for differences in birthweight. A higher chill index during the 48 h after birth reduced survival of both single and twin lambs to a similar extent, but reduced survival of male lambs more than female lambs. There were no effects of birthweight or chill index on lamb survival at the WA site where most lambs weighed more than 4 kg at birth and climatic conditions during lambing were less extreme. Overall, these results supported our hypothesis that improving the nutrition of Merino ewes during pregnancy increases birthweight and this leads to improved survival of their progeny

The merit of condition score and fat score as alternatives to liveweight for managing the nutrition of ewes

The liveweight profile of Merino ewes is related to the production and profitability of the sheep enterprise, but few producers measure liveweight to manage the nutrition of Merino ewes. In this paper we examine the relationship between changes in liveweight and condition score using data from the Lifetimewool project and compare condition score and fat score as alternative monitoring tools. Analyses of liveweight and condition score data from 15 flocks of Merino ewes representing a range of different genotypes and environments showed that the relationship between change in liveweight and condition score was on average 9.2 kg per unit change in condition score or 0.19 times the standard reference weight of the flock. In two experiments experienced operators were used to estimate the condition score and fat score in over 200 ewes and accredited ultrasound scanners measured the eye muscle and fat depth at the C site in the same ewes. All assessments were repeated several times in random order. Within 24 h of the assessments the sheep were slaughtered at local abattoirs where the tissue depth at the GR site was measured on the hot carcasses. Both condition score and fat score were highly repeatable though subject to operator bias. They were related to each other and to the objective measures of fat and eye muscle depth at the C site. However, 95% of sheep below condition score 2.5 had a tissue depth (muscle and fat) at the GR site ≤3 mm, by definition equal to fat score 1. As the condition score of ewes on commercial properties often fluctuates between scores 2 and 3, and small changes in condition score within this range can have large effects on welfare and profit, we conclude that condition score is the most appropriate alternative to liveweight for managing the nutritional profile of ewes

Improving the nutrition of Merino ewes during pregnancy and lactation increases weaning weight and survival of progeny but does not affect their mature size

Lamb growth to weaning, and during the period immediately following weaning, influences post-weaning mortality and may affect mature size. The hypothesis tested in the experiments reported in this paper was that changes in the maternal liveweight of Merino ewes during pregnancy and lactation could predict the weight at weaning, post-weaning survival and mature size of their progeny. At two sites (Vic. and WA) in each of two years, a wide range in the liveweight profiles of ewes was generated during pregnancy and lactation by varying the amount of supplements fed and feed on offer grazed. Across the four experiments this resulted in progeny weights ranging from 13.8 to 28.3 kg just before weaning. Lamb growth was primarily related to the amount of feed on offer during lactation, but was also related to the liveweight change of the ewe during pregnancy. These relationships were consistent in both experiments at each site. Weaning weight was strongly associated with post-weaning survival at the Vic. site. Survival rates decreased significantly when weaning weights were below 20 kg. These results indicate that management of ewe and lamb nutrition to maximise growth of lambs before weaning and growing weaners at 30 g/day or more after weaning are important for optimal post-weaning survival. The findings also suggest that the mature size of offspring is unlikely to be adversely affected by pre-weaning nutrition within the range of nutritional scenarios during pregnancy and lactation that are likely to be experienced within the Australian sheep industry

The national Lifetimewool project: a journey in evaluation

The national Lifetimewool project commenced in 2001 and was funded until 2008. The objective of this project was to develop practical grazing management guidelines that would enable wool growers throughout Australia to increase lifetime production of wool per hectare from ewes. The project achieved its ambitious target of influencing 3000 producers to change their management of ewe flocks by adoption (or part thereof) of Lifetimewool messages and guidelines by 2008. The present paper focuses specifically on the evaluation work that was conducted on the project between 2003 and 2008. It is a noteworthy journey because it provides a case study of the effective implementation of an evaluation plan. The Lifetimewool project used 'people-centred evaluation' to help guide the creation of an internal evaluation plan. The six core principles followed were: participation; program logic, a people-centred focus; multiple lines of evidence; reflection and learning and a clearly documented and resourced evaluation plan. These principles were applied from the onset of the project. The Lifetimewool team used the evaluation findings to refine the initial design. Based on learnings from their evaluation journey, they created and modified the extension and communications components of the project. The present paper contends that the evaluation process itself enabled the project team to plan and adjust the course of the project through evidence-based reflection and that this helped ensure that the targets were achieved and demonstrated