Glioblastoma with leptomeningeal dissemination

Here we report a case of glioblastoma (GB) with leptomeningeal dissemination (LMD) in a 21 year old female presenting with generalized tonic-clonic seizures. After a brain MRI confirmed a non-enhancing left frontal lobe mass, histopathological examination and molecular analysis showed a glioblastoma with features of gliosarcoma that was an IDH wild type, MGMT unmethylated, TERT amplified tumor. She received standard care with combined chemoradiation with temozolomide and targeted radiation. MRI showing disease progression prompted the addition of bevacizumab after which the patient quickly deteriorated and died eight months after initial presentation. Incidence of LMD is an uncommon occurrence and associated with a significant decrease in overall survival when diagnosed at initial presentation. More research is needed to determine what role histopathologic variants and molecular profile plays in prognosis and treatment.peer-reviewe

Influence of Climate Factors and Plant Varieties on the Hay Technology (Fibrous Feed)

The present study was carried on the Research and Didactical Station Jucu located close to Someș River. The aim of the study is to determine the fuel consumption and productivity of aggregates (machineries) used in the conditions of the two levels of hay production technology. The experimental plot uses Festuca Arundinacea, while control, spontaneous vegetation (Dactilys glomerata 70%, Alopecurus pratensis 10% Festuca sp.6%, Trifolium repens 5%, other plants 9%). Grassland soil taken in study type is molded with a high coefficient of withering (16-19%) and a small capacity water output (8%). Chemical characteristics of soil samples shows us a good content in humus and good to very good in mobile potassium, being deficient in phosphorus mobile. The differences noted between the fuel consumptions for the two parcels is due to higher vegetable production of control plot which has also a running speed of different aggregates also influencing effective productivity